公开(公告)号：US3953494A

公开(公告)日：1976-04-27

申请号：US98078

申请日：1970-12-14

申请人： Cal Yale Meyers ,  Walter Sidney Matthews, III

发明人： Cal Yale Meyers ,  Walter Sidney Matthews, III

IPC分类号： C07C45/63 ,  C07C51/00 ,  C07C51/295 ,  C07C51/28 ,  C07C67/42

CPC分类号： C07C251/72 ,  C07C45/63 ,  C07C51/00 ,  C07C51/295

摘要： A process for preparing aldehydes, ketones, carboxylic acids and esters by reaction of various substrates with carbon tetrahalides in the presence of a strong base. The reactions are accelerated by the presence of a polar solvent. Anions of the substrate attack the carbon tetrahalide to produce a halogenated intermediate and a dihalocarbene. The halogenated intermediate reacts with the base to form the indicated products. By the reactions of this process, primary alcohols are converted to aldehydes, carboxylic acids and esters, secondary alcohols are converted to ketones and ketones having an .alpha.-methyl group or both .alpha. and .alpha.' hydrogens are converted to carboxylic acids and esters. Non .alpha.-methyl ketones having .alpha. but no .alpha.' hydrogens are simply .alpha.-halogenated. The dihalocarbene generated in the reaction may attack the product, solvent, or another substrate to form other products.

摘要翻译： 在强碱存在下，通过各种底物与四卤化碳反应来制备醛，酮，羧酸和酯的方法。 通过极性溶剂的存在来加速反应。 底物的阴离子侵蚀四卤化碳以产生卤化中间体和二卤代碳烯。 卤化中间体与碱反应形成指定的产物。 通过该方法的反应，将伯醇转化成醛，羧酸和酯，将仲醇转化成酮，将具有α-甲基或α和α'氢的酮转化为羧酸和酯。 具有α但不含α'氢的非α-甲基酮仅仅是α-卤代的。 在反应中产生的二卤代碳烯可能会侵蚀产物，溶剂或另一种底物以形成其它产物。

公开(公告)号：US3949001A

公开(公告)日：1976-04-06

申请号：US425294

申请日：1973-12-17

申请人： Cal Yale Meyers ,  Walter Sidney Matthews, III ,  Ashok M. Malte

发明人： Cal Yale Meyers ,  Walter Sidney Matthews, III ,  Ashok M. Malte

IPC分类号： C07C1/32 ,  C07C317/00 ,  C07C149/06

CPC分类号： C07C317/00 ,  C07C1/322

摘要： A process for preparing alkenes by reaction of various sulfone substrates with carbon tetrahalide in the presence of a strong base. The reactions are accelerated by the presence of a polar compound. Sulfone carbanions attack the carbon tetrahalide to produce an .alpha.-halogenated intermediate and a dihalocarbene. .alpha.-Halosulfones having .alpha.' hydrogens are converted to alkenes in situ via the Ramberg-Backland reaction. Sulfones having .alpha. but no .alpha.' hydrogens are simply .alpha.-halogenated. The dihalocarbene generated in the reaction may attack the product, solvent, or another substrate to form other products. Alkenes produced by reaction of carbon tetrahalides with di-sec-alkyl sulfones are readily attacked by dihalocarbene to form the alkene-dihalocarbene adduct (a substituted 1,1-dihalocyclopropane).

摘要翻译： 在强碱存在下，各种砜基与碳四卤化物反应制备烯烃的方法。 通过极性化合物的存在来加速反应。 砜砜碳阴离子攻击四卤化碳以产生α-卤代中间体和二卤代碳烯。 具有α'氢的α - α-砜通过Ramberg-Backland反应原位转化为烯烃。 具有α但不含α'氢的砜简单地是α-卤代的。 在反应中产生的二卤代碳烯可能会侵蚀产物，溶剂或另一种底物以形成其它产物。 通过四卤化碳与二仲烷基砜反应产生的烯烃容易被二卤代烃攻击，形成烯烃 - 二卤代碳烯加成物（取代的1,1-二卤代环丙烷）。