公开(公告)号：US20120237496A1

公开(公告)日：2012-09-20

申请号：US13378764

申请日：2010-06-21

Applicant: Joerg Birkenfeld ,  Andrea Eicker ,  Per-Ola Freskgard ,  Claudia Gotzberger-Schad ,  Joanna Grudzinska ,  Ulrich Haupts ,  Josi Innig ,  Christoph Mahlert ,  Andreas Scheidig ,  Michael Strerath ,  Jan Tebbe ,  Johan Per-Wallin ,  Nina Wobst ,  Carl Innes Webster ,  Lutz Jermutus

Inventor： Joerg Birkenfeld ,  Andrea Eicker ,  Per-Ola Freskgard ,  Claudia Gotzberger-Schad ,  Joanna Grudzinska ,  Ulrich Haupts ,  Josi Innig ,  Christoph Mahlert ,  Andreas Scheidig ,  Michael Strerath ,  Jan Tebbe ,  Johan Per-Wallin ,  Nina Wobst ,  Carl Innes Webster ,  Lutz Jermutus

IPC: A61K38/48 ,  C12N9/96 ,  C12N5/10 ,  A61P25/28 ,  C12N1/19 ,  C12N15/63 ,  C12N15/57 ,  C12N9/64 ,  C12N1/15

CPC classification number: C12N9/6494 ,  A61K38/00 ,  C12Y304/24011

Abstract: The present invention relates to polypeptides comprising protease variants of wild type human neprilysin having an altered specificity and/or activity. In particular the present invention relates to polypeptides comprising protease variants derived from human neprilysin having an increased specificity and/or activity against certain substrates, in particular against amyloid beta.

Abstract translation: 本发明涉及包含具有改变的特异性和/或活性的野生型人体炎蛋白的蛋白酶变体的多肽。 特别地，本发明涉及包含衍生自人尼泊金的蛋白酶变体的多肽，其具有针对某些底物，特别是针对淀粉样β的特异性和/或活性增加。

公开(公告)号：US20130177555A1

公开(公告)日：2013-07-11

申请号：US13814657

申请日：2011-08-11

Applicant: Ian Wilkinson ,  Carl Innes Webster ,  David Christopher Lowe

Inventor： Ian Wilkinson ,  Carl Innes Webster ,  David Christopher Lowe

IPC: C07K16/00 ,  C07K14/00

CPC classification number: C07K16/00 ,  C07K14/00 ,  C07K16/28 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/76 ,  C07K2317/94

Abstract: Provided are monomeric polypeptides comprising variant Fc regions and methods of using them. In certain embodiments, monomeric polypeptides of the invention are fusion proteins. In certain embodiments, monomeric polypeptides of the invention are antibodies.

Abstract translation: 提供包含变体Fc区的单体多肽和使用它们的方法。 在某些实施方案中，本发明的单体多肽是融合蛋白。 在某些实施方案中，本发明的单体多肽是抗体。

公开(公告)号：US20100184959A1

公开(公告)日：2010-07-22

申请号：US12532022

申请日：2008-03-19

Applicant: Gulin Guler-Gane ,  Robert George Edward Holgate ,  Lutz Ulrich Jochen Wilhelm Jermutus ,  Jacqueline Michaela Levens ,  John Norman Lund ,  Ross Anthony Stewart ,  Albert George Thom ,  Carl Innes Webster

Inventor： Gulin Guler-Gane ,  Robert George Edward Holgate ,  Lutz Ulrich Jochen Wilhelm Jermutus ,  Jacqueline Michaela Levens ,  John Norman Lund ,  Ross Anthony Stewart ,  Albert George Thom ,  Carl Innes Webster

IPC: C07K16/00 ,  C12P21/00 ,  C12P19/34

CPC classification number: C07K16/00 ,  C07K16/2887 ,  C07K2317/72 ,  C07K2317/732 ,  C40B30/04 ,  C40B40/10 ,  C40B50/10

Abstract: The present invention relates to methods for selecting, obtaining or producing Fc variant polypeptides which show altered recognition for an Fc ligand (e.g., FcγR, CIq). Additionally, the Fc variant polypeptides may have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variant polypeptides particularly for therapeutic purposes.

Abstract translation: 本发明涉及用于选择，获得或产生对Fc配体（例如FcγR，C1q）具有改变的识别的Fc变体多肽的方法。 另外，Fc变体多肽可能具有改变的抗体依赖性细胞介导的细胞毒性（ADCC）和/或补体依赖性细胞毒性（CDC）活性。 本发明还提供了用于应用所述Fc变体多肽的方法和方案，特别是用于治疗目的。

公开(公告)号：US06323393B1

公开(公告)日：2001-11-27

申请号：US09077418

申请日：1998-08-18

Applicant: John Clinton Gray ,  Jagdeep Singh Sandhu ,  Carl Innes Webster

Inventor： John Clinton Gray ,  Jagdeep Singh Sandhu ,  Carl Innes Webster

IPC: C12N1582

CPC classification number: C12N15/8222 ,  C07K14/415 ,  C12N15/8216

Abstract: The invention provides enhancers for one or more gene promoters, which enhancers are nucleotide sequences rich in A and T bases, the total amount of A and T bases comprising more than 50% of the nucleotide sequence. Particular sequences are identified from the pea plastocyanin promoter which are active as enhancers, as is a solely A/T nucleotide sequence, and methods of carrying out the invention are described.

Abstract translation: 本发明提供了一种或多种基因启动子的增强子，其增强子是富含A和T碱基的核苷酸序列，A和T碱基的总量占核苷酸序列的50％以上。 从作为增强剂的豌豆质粒蛋白启动子鉴定出特定的序列，以及单独的A / T核苷酸序列，描述了实施本发明的方法。