公开(公告)号：US20120237496A1

公开(公告)日：2012-09-20

申请号：US13378764

申请日：2010-06-21

申请人： Joerg Birkenfeld ,  Andrea Eicker ,  Per-Ola Freskgard ,  Claudia Gotzberger-Schad ,  Joanna Grudzinska ,  Ulrich Haupts ,  Josi Innig ,  Christoph Mahlert ,  Andreas Scheidig ,  Michael Strerath ,  Jan Tebbe ,  Johan Per-Wallin ,  Nina Wobst ,  Carl Innes Webster ,  Lutz Jermutus

发明人： Joerg Birkenfeld ,  Andrea Eicker ,  Per-Ola Freskgard ,  Claudia Gotzberger-Schad ,  Joanna Grudzinska ,  Ulrich Haupts ,  Josi Innig ,  Christoph Mahlert ,  Andreas Scheidig ,  Michael Strerath ,  Jan Tebbe ,  Johan Per-Wallin ,  Nina Wobst ,  Carl Innes Webster ,  Lutz Jermutus

IPC分类号： A61K38/48 ,  C12N9/96 ,  C12N5/10 ,  A61P25/28 ,  C12N1/19 ,  C12N15/63 ,  C12N15/57 ,  C12N9/64 ,  C12N1/15

CPC分类号： C12N9/6494 ,  A61K38/00 ,  C12Y304/24011

摘要： The present invention relates to polypeptides comprising protease variants of wild type human neprilysin having an altered specificity and/or activity. In particular the present invention relates to polypeptides comprising protease variants derived from human neprilysin having an increased specificity and/or activity against certain substrates, in particular against amyloid beta.

摘要翻译： 本发明涉及包含具有改变的特异性和/或活性的野生型人体炎蛋白的蛋白酶变体的多肽。 特别地，本发明涉及包含衍生自人尼泊金的蛋白酶变体的多肽，其具有针对某些底物，特别是针对淀粉样β的特异性和/或活性增加。

公开(公告)号：US20120108796A1

公开(公告)日：2012-05-03

申请号：US13323691

申请日：2011-12-12

申请人： Zhuozhi WANG ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi WANG ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： C07K16/18

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

公开(公告)号：US08481030B2

公开(公告)日：2013-07-09

申请号：US13323691

申请日：2011-12-12

申请人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： A61K39/395

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体。 还考虑了编码结合TFPI的单克隆抗体的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。

公开(公告)号：US09309324B2

公开(公告)日：2016-04-12

申请号：US13582401

申请日：2011-03-01

申请人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： A61K39/395 ,  C07K16/38 ,  A61K39/00

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

公开(公告)号：US20120329996A1

公开(公告)日：2012-12-27

申请号：US13582401

申请日：2011-03-01

申请人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： C07K16/18

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体。 还考虑了编码结合TFPI的单克隆抗体的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。