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公开(公告)号:US09422347B2
公开(公告)日:2016-08-23
申请号:US14123519
申请日:2012-05-01
IPC分类号: A01N63/00 , C07K14/445 , A61K39/015 , C12N1/12 , C12N15/82 , A61K39/00
CPC分类号: C07K14/445 , A61K39/015 , A61K2039/517 , A61K2039/6037 , C12N1/12 , C12N15/8214 , C12N15/8258 , Y02A50/412
摘要: The present invention relates to the production of malaria transmission blocking vaccines in single-celled green algae, particularly algae of the genus Chlamydomonas, e.g., Chlamydomonas reinhardtii; the immunogenic Plasmodium polypeptides produced and compositions comprising them; and methods for preventing, ameliorating, reducing, delaying, treating and blocking the transmission of malaria by administration of immunogenic Plasmodium polypeptides produced in an algal host cell.
摘要翻译: 本发明涉及在单细胞绿藻,特别是衣藻属例如莱茵衣藻的藻类中生产疟疾传播阻断疫苗; 产生的免疫原性疟原虫多肽和包含它们的组合物; 以及通过施用在藻类宿主细胞中产生的免疫原性疟原虫多肽来预防,改善,减少,延迟,治疗和阻断疟疾传播的方法。
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公开(公告)号:US20140219971A1
公开(公告)日:2014-08-07
申请号:US14123519
申请日:2012-05-01
IPC分类号: C07K14/445
CPC分类号: C07K14/445 , A61K39/015 , A61K2039/517 , A61K2039/6037 , C12N1/12 , C12N15/8214 , C12N15/8258 , Y02A50/412
摘要: The present invention relates to the production of malaria transmission blocking vaccines in single-celled green algae, particularly algae of the genus Chlamydomonas, e.g., Chlamydomonas reinhardtii; the immunogenic Plasmodium polypeptides produced and compositions comprising them; and methods for preventing, ameliorating, reducing, delaying, treating and blocking the transmission of malaria by administration of immunogenic Plasmodium polypeptides produced in an algal host cell.
摘要翻译: 本发明涉及在单细胞绿藻,特别是衣藻属例如莱茵衣藻的藻类中生产疟疾传播阻断疫苗; 产生的免疫原性疟原虫多肽和包含它们的组合物; 以及通过施用在藻类宿主细胞中产生的免疫原性疟原虫多肽来预防,改善,减少,延迟,治疗和阻断疟疾传播的方法。
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