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公开(公告)号:US5541095A
公开(公告)日:1996-07-30
申请号:US57167
申请日:1993-04-30
申请人: Carlos B. Hirschberg , Ariel Orellana , Yasuhiro Hashimoto , Stuart J. Swiedler , Zheng Wei , Masayuki Ishihara
发明人: Carlos B. Hirschberg , Ariel Orellana , Yasuhiro Hashimoto , Stuart J. Swiedler , Zheng Wei , Masayuki Ishihara
摘要: DNA encoding a polypeptide capable of catalyzing the deacetylation and sulfation of a glycosaminoglycan; production and isolation of recombinant and synthetic polypeptides capable of catalyzing the deacetylation, sulfation or both the deacetylation and sulfation of a glycosaminoglycan; antibodies to the polypeptides of the invention; and therapeutic uses of these compounds are disclosed.
摘要翻译: 编码能够催化糖胺聚糖脱乙酰化和硫酸化的多肽的DNA; 能够催化葡糖胺聚糖的脱乙酰化,硫酸化或脱乙酰化和硫酸化两者的重组和合成多肽的生产和分离; 对本发明多肽的抗体; 并公开了这些化合物的治疗用途。