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公开(公告)号：US08497271B2
公开(公告)日：2013-07-30
申请号：US12895916
申请日：2010-10-01
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/496 , A61K31/165 , A61K31/381 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , C07C233/60 , C07D333/24 , C07D409/12
CPC分类号： C07D333/24 , C07C233/60 , C07C2601/02
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
摘要翻译： 本公开一般涉及可以调节G蛋白偶联受体88的化合物，包含这些化合物的组合物，以及调节G蛋白偶联受体88的方法。
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公开(公告)号：US08426414B2
公开(公告)日：2013-04-23
申请号：US12897004
申请日：2010-10-04
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
IPC分类号： C07D213/56 , C07D241/12 , A61K31/4418 , A61K31/4965 , A61P25/00
CPC分类号： C07D213/56 , C07D241/12
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
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公开(公告)号：US20110245264A1
公开(公告)日：2011-10-06
申请号：US12895916
申请日：2010-10-01
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/496 , C07D333/24 , A61K31/381 , C07D409/12 , C07C233/60 , A61K31/165 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/30
CPC分类号： C07D333/24 , C07C233/60 , C07C2601/02
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
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公开(公告)号：US07067658B2
公开(公告)日：2006-06-27
申请号：US10670519
申请日：2003-09-26
IPC分类号： C07D471/04 , C07D475/00 , A61K31/4985 , A61K31/519 , A61P25/24
CPC分类号： C07D471/04 , C07D475/00
摘要： The present invention provides compounds of Formula I: wherein the variables A, B, Ar, R1, R2, and R3 are as defined herein. The compounds of Formula (I) can function as corticotropin releasing factor (CRF) receptor antagonists and can be useful, for example, in the treatment of disorders characterized by abnormal levels of CRF such as anxiety and depression.
摘要翻译： 本发明提供式I化合物：其中变量A，B，Ar，R 1，R 2和R 3均为 本文定义。 式（I）的化合物可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂，并且可用于例如治疗特征为CRF异常水平（例如焦虑和抑郁症）的疾病。
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公开(公告)号：US08304577B2
公开(公告)日：2012-11-06
申请号：US12898016
申请日：2010-10-05
申请人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
发明人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
IPC分类号： C07C233/00
CPC分类号： C07D207/40 , C07B2200/07 , C07C233/22 , C07C233/40 , C07C237/06 , C07C2601/02 , C07C2601/08 , C07D213/40 , C07D231/12 , C07D277/32
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
摘要翻译： 本公开一般涉及可以调节G蛋白偶联受体88的化合物，包含这些化合物的组合物，以及调节G蛋白偶联受体88的方法。
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公开(公告)号：US20110251204A1
公开(公告)日：2011-10-13
申请号：US12897004
申请日：2010-10-04
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/4418 , C07D405/12 , A61K31/4433 , C07D241/12 , A61K31/4965 , A61P3/10 , A61P3/00 , A61P25/16 , A61P25/30 , A61P25/28 , A61P25/18 , A61P25/00 , C07D213/56 , A61P3/04
CPC分类号： C07D213/56 , C07D241/12
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
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公开(公告)号：US20110251196A1
公开(公告)日：2011-10-13
申请号：US12898016
申请日：2010-10-05
申请人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
发明人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/5375 , A61K31/40 , C07C233/16 , A61K31/165 , C07C233/43 , C07D241/04 , A61K31/495 , C07D265/30 , C07D277/30 , A61K31/426 , C07C237/20 , C07D307/14 , A61K31/341 , C07D213/56 , A61K31/4406 , C07D209/26 , A61K31/4045 , C07D231/12 , A61K31/415 , A61P25/00 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/36 , C07D207/09
CPC分类号： C07D207/40 , C07B2200/07 , C07C233/22 , C07C233/40 , C07C237/06 , C07C2601/02 , C07C2601/08 , C07D213/40 , C07D231/12 , C07D277/32
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
摘要翻译： 本公开一般涉及可以调节G蛋白偶联受体88的化合物，包含这些化合物的组合物，以及调节G蛋白偶联受体88的方法。
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