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1.发明授权5, 6, or 7-substituted -3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof 有权5,6或7-取代的-3-（杂）芳基异喹啉胺衍生物及其治疗用途公开(公告)号：US08314123B2
公开(公告)日：2012-11-20
申请号：US13268678
申请日：2011-10-07
申请人： Young Bok Lee , Chang Ho Ahn , Won-Jea Cho
发明人： Young Bok Lee , Chang Ho Ahn , Won-Jea Cho
IPC分类号： A61K31/472 , C07D217/22
CPC分类号： C07D409/04 , C07D217/22 , C07D401/04 , C07D405/04
摘要： The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
摘要翻译： 本发明涉及由通式D表示的5,6或7-取代的3-（杂）芳基异喹啉胺衍生物及其药理学上可接受的盐，以及含有这些化合物的组合物。 还包括通过施用化合物治疗过度增殖性疾病的方法。
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![1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives](/abs-image/US/2012/11/20/US08314100B2/abs.jpg.150x150.jpg)
2.发明授权1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives 有权1- [6,7-取代的烷氧基喹喔啉基]氨基羰基] -4-（杂）芳基哌嗪衍生物公开(公告)号：US08314100B2
公开(公告)日：2012-11-20
申请号：US11667923
申请日：2005-10-18
申请人： Young-Dae Gong , Moon-Kook Jeon , Dong-Su Kim , Jae Yang Kong , Gun-Do Kim , Chang-Ho Ahn , Young Bok Lee
发明人： Young-Dae Gong , Moon-Kook Jeon , Dong-Su Kim , Jae Yang Kong , Gun-Do Kim , Chang-Ho Ahn , Young Bok Lee
IPC分类号： A61K31/495
CPC分类号： C07D401/12 , C07D241/44 , C07D403/12
摘要： The present invention related to a novel urea derivative for formula (I): which is useful as an anti-cancer agent, its pharmaceutically acceptable acid addition salt or stereoisomer, and to a process for preparing the urea derivative and an anti-cancer composition comprising the same as an active ingredient.
摘要翻译： 本发明涉及用于式（I）的新型脲衍生物：其可用作抗癌剂，其药学上可接受的酸加成盐或立体异构体，以及制备尿素衍生物的方法和抗癌组合物，其包含 与活性成分相同。
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公开(公告)号：US20140275129A1
公开(公告)日：2014-09-18
申请号：US14212031
申请日：2014-03-14
申请人： Young Bok Lee , Jae Min Kim , Deog Joong Kim , Chang-Ho Ahn
发明人： Young Bok Lee , Jae Min Kim , Deog Joong Kim , Chang-Ho Ahn
IPC分类号： C07D401/06 , C07D401/14 , C07D417/14
CPC分类号： A61K31/517 , A61K47/66 , C07D401/06 , C07D401/14 , C07D417/14
摘要： Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.
摘要翻译： 描述了由式（I）表示的四氢异喹啉-2-基 - （喹唑啉-4-基）甲酮衍生物，其药理学上可接受的盐，以及含有这些化合物的组合物。 还描述了通过施用化合物治疗过度增殖性疾病的方法。 还描述了用于制备四氢异喹啉-2-基 - （喹唑啉-4-基）甲酮化合物的1,2,3,4-四氢异喹啉衍生物。
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公开(公告)号：US07405214B2
公开(公告)日：2008-07-29
申请号：US11095686
申请日：2005-04-01
申请人： Young Bok Lee , Chang Ho Ahn , Won Jun Choi , Lak Shin Jeong , Sang Kook Lee
发明人： Young Bok Lee , Chang Ho Ahn , Won Jun Choi , Lak Shin Jeong , Sang Kook Lee
IPC分类号： A01N43/04 , A01N43/54 , A61K31/70 , A61K31/505 , C07D239/00
CPC分类号： C07D239/47 , A61K31/513 , C07D239/54 , C07D239/553
摘要： The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
摘要翻译： 本发明涉及由通式I和II表示的核苷衍生物，其合成方法及其药理学上可接受的盐，以及含有这些化合物的组合物。 还包括通过施用化合物治疗过度增殖性疾病的方法。
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5.发明授权公开(公告)号：US07122527B2
公开(公告)日：2006-10-17
申请号：US10640167
申请日：2003-08-13
申请人： Heejeong Yoon , Lingjun Mao , Young Bok Lee , Chang Ho Ahn
发明人： Heejeong Yoon , Lingjun Mao , Young Bok Lee , Chang Ho Ahn
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12Y207/01037
摘要： New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.
摘要翻译： 新的反义寡核苷酸化合物抑制Akt-1的表达，并在几种癌细胞系中诱导细胞毒性。
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6.发明授权公开(公告)号：US09193707B2
公开(公告)日：2015-11-24
申请号：US14212031
申请日：2014-03-14
申请人： Young Bok Lee , Jae Min Kim , Deog Joong Kim , Chang-Ho Ahn
发明人： Young Bok Lee , Jae Min Kim , Deog Joong Kim , Chang-Ho Ahn
IPC分类号： C07D401/06 , C07D417/14 , C07D401/14
CPC分类号： A61K31/517 , A61K47/66 , C07D401/06 , C07D401/14 , C07D417/14
摘要： Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.
摘要翻译： 描述了由式（I）表示的四氢异喹啉-2-基 - （喹唑啉-4-基）甲酮衍生物，其药理学上可接受的盐，以及含有这些化合物的组合物。 还描述了通过施用化合物治疗过度增殖性疾病的方法。 还描述了用于制备四氢异喹啉-2-基 - （喹唑啉-4-基）甲酮化合物的1,2,3,4-四氢异喹啉衍生物。
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公开(公告)号：US08404698B2
公开(公告)日：2013-03-26
申请号：US12213182
申请日：2008-06-16
申请人： Young Bok Lee , Chang Ho Ahn
发明人： Young Bok Lee , Chang Ho Ahn
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70 , C07D239/94
CPC分类号： A61K31/517
摘要： Quinazoline derivatives represented by the general formula pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for using the compounds for treatment of hyperproliferative disorders are also disclosed.
摘要翻译： 描述了由通式其药理学上可接受的盐代表的喹唑啉衍生物和含有这些化合物的组合物。 还公开了用于治疗过度增殖性疾病的化合物的方法。
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![1-[6,7-Substituted Alkoxyquinoxalinyl) Aminocarbonyl]-4-(Hetero) Arylpiperazine Derivatives](/abs-image/US/2008/12/25/US20080318963A1/abs.jpg.150x150.jpg)
8.发明申请1-[6,7-Substituted Alkoxyquinoxalinyl) Aminocarbonyl]-4-(Hetero) Arylpiperazine Derivatives 有权1- [6,7-取代的烷氧基喹喔啉基]氨基羰基] -4-（杂）芳基哌嗪衍生物公开(公告)号：US20080318963A1
公开(公告)日：2008-12-25
申请号：US11667923
申请日：2005-10-18
申请人： Young-Dae Gong , Moon-Kook Jeon , Dong-Su Kim , Jae Yang Kong , Gun-Do Kim , Chang-Ho Ahn , Young Bok Lee
发明人： Young-Dae Gong , Moon-Kook Jeon , Dong-Su Kim , Jae Yang Kong , Gun-Do Kim , Chang-Ho Ahn , Young Bok Lee
IPC分类号： A61K31/498 , C07D403/12
CPC分类号： C07D401/12 , C07D241/44 , C07D403/12
摘要： The present invention relates to novel quinoxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives and their pharmaceutically acceptable salts, a process for their preparation thereof, and compositions containing such compounds. Therapeutic methods for the treatment of hyperproliferative disorders, including cancers, by administering quinoxalin-piperazine compounds are also included.
摘要翻译： 本发明涉及新的喹喔啉 - 哌嗪化合物，1 - [（6,7-取代的烷氧基喹喔啉基）氨基羰基] -4-（杂）芳基哌嗪衍生物及其药学上可接受的盐，其制备方法和含有这些化合物的组合物 。 还包括通过施用喹喔啉 - 哌嗪化合物治疗过度增殖性疾病（包括癌症）的治疗方法。
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公开(公告)号：US07205283B2
公开(公告)日：2007-04-17
申请号：US10766185
申请日：2004-01-28
申请人： Heejeong Yoon , Lingjun Mao , Young Bok Lee , Chang-Ho Ahn , Xiaoming Jiang
发明人： Heejeong Yoon , Lingjun Mao , Young Bok Lee , Chang-Ho Ahn , Xiaoming Jiang
CPC分类号： C12N15/1137 , A61K48/00 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12Q1/6886
摘要： New antisense oligonucleotide compounds, RX-0047 and RX-0149, inhibit expression of HIF-1 and also induce cytotoxicity in several cancer cell lines.
摘要翻译： 新的反义寡核苷酸化合物RX-0047和RX-0149抑制HIF-1的表达，并在几种癌细胞系中诱导细胞毒性。
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