公开(公告)号：US08426383B2

公开(公告)日：2013-04-23

申请号：US12922353

申请日：2009-03-12

Applicant: Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Kang II Ko

Inventor： Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Kang II Ko

IPC: A61K8/73 ,  A61K31/728 ,  A61P17/00 ,  A61Q19/08 ,  A61Q19/00

CPC classification number: A61K8/735 ,  A61K8/97 ,  A61K36/185 ,  A61Q19/08

Abstract: Disclosed is an anti-aging composition for external use on skin, which includes low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, as active ingredients. The composition including the low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, in a predetermined ratio, shows significantly improved skin-moisturizing, skin elasticity-enhancing and inflammation-alleviating effects, as compared to a composition using one of the above ingredients alone. Therefore, the composition may be widely used as a pharmaceutical or cosmetic anti-aging composition.

Abstract translation: 本发明公开了一种外用于皮肤的抗衰老组合物，其包括低分子量透明质酸，高分子量透明质酸和从榆树根皮提取的多糖作为活性成分。 包含低分子量透明质酸，高分子量透明质酸和以榆树根皮提取的多糖的组合物按预定比例显示出显着改善的皮肤保湿，皮肤弹性增强和炎症缓解作用，如 与仅使用上述成分之一的组合物相比。 因此，该组合物可广泛用作药物或化妆品抗衰老组合物。

公开(公告)号：US20110207830A1

公开(公告)日：2011-08-25

申请号：US13120818

申请日：2009-09-25

Applicant: Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Sang iL Lee

Inventor： Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Sang iL Lee

IPC: A61K31/075 ,  A61P25/28 ,  A61P25/00

CPC classification number: A61K31/085 ,  A23L2/52 ,  A23L33/105 ,  A61K31/05 ,  A61K36/575

Abstract: Disclosed is a composition for treating or preventing amyloid-related diseases including 4-O-methylhonokiol as an active ingredient. More specifically, a pharmaceutical composition including 4-O-methylhonokiol, which is effective for treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorder, defective memory, amyloidosis, etc. is disclosed. The inventors of the present disclosure have found out for the first time that 4-O-methylhonokiol inhibits the production of β-amyloid. It has been confirmed to be useful in treating or preventing amyloid-related diseases. Through animal tests including water maze test and passive avoidance test on mice, 4-O-methylhonokiol has been confirmed to be effective for amyloid-related diseases such as Alzheimer's disease, defective memory, cognitive disorder, and the like. It was further confirmed through acetylcholinesterase activity inhibition test using mouse brain cortex and hippocampus tissue that they are particularly effective in treating or preventing Alzheimer's disease among the amyloid-related diseases.

Abstract translation: 公开了用于治疗或预防淀粉样蛋白相关疾病的组合物，包括4-O-甲基联苯甲醇作为活性成分。 更具体地说，公开了一种药物组合物，其包含对于治疗或预防淀粉样蛋白相关疾病如阿尔茨海默氏病，认知障碍，缺陷记忆，淀粉样变性等有效的4-O-甲基联苯甲醇。 本公开的发明人首次发现4-O-甲基胡酮醇抑制β-淀粉样蛋白的产生。 已经证实可用于治疗或预防淀粉样蛋白相关疾病。 通过动物试验，包括水迷宫试验和小鼠被动回避试验，已证实4-O-甲基黑叶醇对淀粉样蛋白相关疾病如阿尔茨海默病，记忆缺陷，认知障碍等有效。 通过使用小鼠脑皮层和海马组织的乙酰胆碱酯酶活性抑制试验进一步证实，它们在淀粉样蛋白相关疾病中治疗或预防阿尔茨海默氏病方面特别有效。

公开(公告)号：US08604087B2

公开(公告)日：2013-12-10

申请号：US13120818

申请日：2009-09-25

Applicant: Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Sang iL Lee

Inventor： Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Sang iL Lee

IPC: A01N31/04 ,  A01N31/08

CPC classification number: A61K31/085 ,  A23L2/52 ,  A23L33/105 ,  A61K31/05 ,  A61K36/575

Abstract: Disclosed is a composition for treating or preventing amyloid-related diseases including 4-O-methylhonokiol as an active ingredient. More specifically, a pharmaceutical composition including 4-O-methylhonokiol, which is effective for treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorder, defective memory, amyloidosis, etc. is disclosed. The inventors of the present disclosure have found out for the first time that 4-O-methylhonokiol inhibits the production of β-amyloid. It has been confirmed to be useful in treating or preventing amyloid-related diseases. Through animal tests including water maze test and passive avoidance test on mice, 4-O-methylhonokiol has been confirmed to be effective for amyloid-related diseases such as Alzheimer's disease, defective memory, cognitive disorder, and the like. It was further confirmed through acetylcholinesterase activity inhibition test using mouse brain cortex and hippocampus tissue that they are particularly effective in treating or preventing Alzheimer's disease among the amyloid-related diseases.

Abstract translation: 公开了用于治疗或预防淀粉样蛋白相关疾病的组合物，包括4-O-甲基联苯甲醇作为活性成分。 更具体地说，公开了一种药物组合物，其包含对于治疗或预防淀粉样蛋白相关疾病如阿尔茨海默氏病，认知障碍，缺陷记忆，淀粉样变性等有效的4-O-甲基联苯甲醇。 本公开的发明人首次发现4-O-甲基联苯酚抑制β-淀粉样蛋白的产生。 已经证实可用于治疗或预防淀粉样蛋白相关疾病。 通过动物试验，包括水迷宫试验和小鼠被动回避试验，已证实4-O-甲基黑叶醇对淀粉样蛋白相关疾病如阿尔茨海默病，记忆缺陷，认知障碍等有效。 通过使用小鼠脑皮层和海马组织的乙酰胆碱酯酶活性抑制试验进一步证实，它们在淀粉样蛋白相关疾病中治疗或预防阿尔茨海默氏病方面特别有效。

公开(公告)号：US20110003769A1

公开(公告)日：2011-01-06

申请号：US12922353

申请日：2009-03-12

Applicant: Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Kang Il Ko

Inventor： Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Kang Il Ko

IPC: A61K8/73 ,  A61K31/728 ,  A61P17/00 ,  A61P29/00 ,  A61Q19/08 ,  A61Q19/00

CPC classification number: A61K8/735 ,  A61K8/97 ,  A61K36/185 ,  A61Q19/08

Abstract: Disclosed is an anti-aging composition for external use on skin, which includes low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, as active ingredients. The composition including the low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, in a predetermined ratio, shows significantly improved skin-moisturizing, skin elasticity-enhancing and inflammation-alleviating effects, as compared to a composition using one of the above alone. Therefore, the composition may be widely used as a pharmaceutical or cosmetic anti-aging composition.

Abstract translation: 本发明公开了一种外用于皮肤的抗衰老组合物，其包括低分子量透明质酸，高分子量透明质酸和从榆树根皮提取的多糖作为活性成分。 包含低分子量透明质酸，高分子量透明质酸和以榆树根皮提取的多糖的组合物按预定比例显示出显着改善的皮肤保湿，皮肤弹性增强和炎症缓解作用，如 与使用上述单独的组合物相比。 因此，该组合物可广泛用作药物或化妆品抗衰老组合物。