公开(公告)号：US20110200996A1

公开(公告)日：2011-08-18

申请号：US12959349

申请日：2010-12-02

申请人： Jeffrey W. Smith ,  Changming FANG

发明人： Jeffrey W. Smith ,  Changming FANG

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.

摘要翻译： 我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。 由IBABP-L编码的蛋白质包含在IBABP蛋白中未发现的49个残基的N-末端序列。 本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

公开(公告)号：US20090074785A1

公开(公告)日：2009-03-19

申请号：US12009173

申请日：2008-01-16

申请人： Jeffrey W. Smith ,  Changming Fang

发明人： Jeffrey W. Smith ,  Changming Fang

IPC分类号： A61K39/395 ,  A61K31/7105 ,  A61K31/575 ,  A61P35/00 ,  G01N33/53 ,  A61K39/00

CPC分类号： A61K48/0058 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  G01N33/5011 ,  G01N2500/02

摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides, for example, compositions and methods for diagnosing and treating colorectal cancer.

摘要翻译： 我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。 由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。 本发明提供例如用于诊断和治疗结肠直肠癌的组合物和方法。

公开(公告)号：US20090005307A1

公开(公告)日：2009-01-01

申请号：US11992279

申请日：2006-09-21

申请人： Jeffrey W. Smith ,  Changming Fang

发明人： Jeffrey W. Smith ,  Changming Fang

IPC分类号： A61K38/17 ,  C12N15/12 ,  C07H21/00 ,  C12N15/79 ,  C07K16/18 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/574 ,  C12N15/11 ,  C12N5/10

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.

摘要翻译： 我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。 由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。 本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

公开(公告)号：US08563248B2

公开(公告)日：2013-10-22

申请号：US12959349

申请日：2010-12-02

申请人： Jeffrey W. Smith ,  Changming Fang

发明人： Jeffrey W. Smith ,  Changming Fang

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.

摘要翻译： 我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。 由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。 本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。