公开(公告)号：US20100041124A1

公开(公告)日：2010-02-18

申请号：US12523279

申请日：2008-01-24

申请人： Ho Nam Chang ,  Byoungjin Kim ,  Changmoon Jeong ,  Jong Won Kang ,  Joongkon Park

发明人： Ho Nam Chang ,  Byoungjin Kim ,  Changmoon Jeong ,  Jong Won Kang ,  Joongkon Park

IPC分类号： C12N1/00 ,  C12M1/14

CPC分类号： C12M27/02 ,  C12M23/58 ,  C12M25/18

摘要： The present invention relates to a single CSTR bioreactor equipped with a cell recycle unit, and a multi-stage CSTR bioreactor system in which 2-7 such single CSTR bioreactors are connected in series with each other. According to the present invention, multi-stage fermentation is carried out in the bioreactor equipped with the cell recycle unit, and thus the production of products (alcohols, organic acids, antibiotics, recombinant proteins, etc.) by anaerobic or aerobic microbial fermentation can be increased, and in addition, a final product can be obtained at high concentration, thus improving the productivity and economic efficiency of a microbial process.

摘要翻译： 本发明涉及装备有细胞再循环单元的单个CSTR生物反应器和多级CSTR生物反应器系统，其中2-7个这样的单个CSTR生物反应器彼此串联连接。 根据本发明，在配备有细胞循环装置的生物反应器中进行多级发酵，因此通过厌氧或需氧微生物发酵生产产物（醇，有机酸，抗生素，重组蛋白等）可以 并且另外可以以高浓度获得最终产品，从而提高微生物过程的生产率和经济效率。