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公开(公告)号：US20240360397A1
公开(公告)日：2024-10-31
申请号：US18647679
申请日：2024-04-26
申请人： CORNING INCORPORATED
发明人： Ye Fang , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Joel Andrew Schultes , Elena Ravilievna Streltsova , Todd Michael Upton , Jennifer Lynn Weber
摘要： A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.
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公开(公告)号：US20240228940A1
公开(公告)日：2024-07-11
申请号：US18573720
申请日：2022-06-09
申请人： CORNING INCORPORATED
摘要： A bioreactor system for culturing cells is provided. The system includes a cell culture vessel with an interior reservoir. an inlet and an outlet fluidly connected to the reservoir. A fluid flow path supplies fluid to the inlet and receives fluid from the outlet. and a media conditioning vessel is fluidly connected to the cell culture vessel. The system also includes an outlet sensor arranged at the outlet of the cell culture vessel. The outlet sensor can detect a property of cell culture media exiting the cell culture vessel via the outlet, and the bioreactor system can adjust a property of the cell culture media based on the property detected by the outlet sensor.
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公开(公告)号：US11827907B2
公开(公告)日：2023-11-28
申请号：US17748664
申请日：2022-05-19
发明人： Perry Newton , Dalton Berrie , Tyler Grow , Sheldon Doxilly , Christopher J. Montoya , Sara Jane Terpening , Eric Vela
CPC分类号： C12N7/00 , C12M25/18 , C12M41/12 , C12M41/34 , C12M41/36 , C12N2760/20234 , C12N2760/20243 , C12N2760/20251
摘要： The invention relates to a method of increasing the yield of virus, virus particles, or viral vectors from host cells in a bioreactor. The invention provides a reproducible and robust method and system of determining and controlling the optimal time of infection of host cells using a correlation of process air parameters including Air flow, O2 flow, and respective trends thereof resulting in increased virus yield.
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公开(公告)号：US20190241848A1
公开(公告)日：2019-08-08
申请号：US16312238
申请日：2017-06-21
申请人： Qvidja Kraft AB
发明人： Anni ALITALO , Marko NISKANEN , Erkki AURA
CPC分类号： C12M21/04 , C12M1/04 , C12M1/107 , C12M1/16 , C12M25/18 , C12N1/20 , C12N11/14 , C12P1/04 , C12P5/02 , C12P7/02 , C12P7/40
摘要： An active solid state fermentation bioreactor for producing gases, liquid(s) or solids from gaseous or gaseous and liquid starting materials and a fermentation process using the reactor are disclosed. The bioreactor includes three major phases; a solid phase including the porous solid support, a liquid phase comprising liquid, and a gaseous phase. The solid phase includes a porous solid support, in which at least 20% of the pore volumes have a size resulting in a liquid suction of about 0.01 to about 0.1 bars if these pores are filled with liquid, the porous solid support is inoculated with desired micro-organisms, the volume of the gaseous phase is 20% to 60% of the volume of the bioreactor, and the liquid phase is at least 20% of the reactor volume. The unsaturated capillary conductivity of filling/packing solid material of the bioreactor is at least 0.1 cm/h. The solid state fermentation bioreactor enables a large gas-liquid interface, in which the filling material has a good capillary conductivity despite the unsaturated state.
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5.发明授权Bioreactor to obtain bioactive substances through solid-state fermentation using macromycetes fungi 有权生物反应器通过使用大肠杆菌真菌的固态发酵获得生物活性物质公开(公告)号：US09556409B2
公开(公告)日：2017-01-31
申请号：US13865035
申请日：2013-04-17
摘要： Fixed bed bioreactor with natural convection and forced draught to obtain bioactive substances by solid-state fermentation (SEF) using fungi macromycetes. This bioreactor may be from turn drum with pendulum motion and natural and forced convection to a tray bioreactor with natural convection. They are used in the production of bioactive substances as crude extracts of lignocellulosic enzymes and fungal polysaccharides obtained by using mixtures of lignocellulosic materials as substrates and macromycetes fungi as inoculum, controlling pH, humidity and particle size, inoculation rate and environmental conditions during fermentation such as temperature, relative humidity and carbon dioxide and oxygen concentration.
摘要翻译： 具有自然对流和强制通风的固定床生物反应器通过使用真菌大肠杆菌的固态发酵（SEF）获得生物活性物质。 该生物反应器可以是具有摆动运动的转鼓和自然和强制对流到具有自然对流的塔板生物反应器。 它们用于生产生物活性物质，作为木质纤维素酶的粗提取物和通过使用木质纤维素材料作为底物和大肠杆菌真菌作为接种物的混合物获得的真菌多糖，控制pH，湿度和粒度，接种速率和发酵期间的环境条件，例如 温度，相对湿度和二氧化碳和氧气浓度。
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公开(公告)号：US20150299634A1
公开(公告)日：2015-10-22
申请号：US14648590
申请日：2013-12-11
CPC分类号： C12M23/34 , C12M23/26 , C12M25/14 , C12M25/18 , C12M27/12 , C12M29/14 , C12M33/08 , C12M33/12 , C12M33/14 , C12M33/18 , C12M47/02
摘要： A recipient for cell cultivation having an inner compartment adapted for cell growth, in one embodiment, an outer tubular wall extends in a longitudinal direction and delimits an outer boundary of the inner compartment in a radial direction. First and second ends delimit the inner compartment at the first respectively the second outer end of the outer tubular wail. A fixed packing in the inner compartment comprises a packing, such as a fiber matrix. Additional embodiments and related methods are also disclosed.
摘要翻译： 具有适于细胞生长的内隔室的细胞培养的受体，在一个实施方案中，外管状壁在纵向方向上延伸并且在径向方向上限定内隔室的外边界。 第一和第二端在外管状壁的第一分别的第二外端限定内隔室。 内隔室中的固定填料包括诸如纤维基质的填料。 还公开了另外的实施例和相关方法。
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7.发明申请BIOREACTOR TO OBTAIN BIOACTIVE SUBSTANCES THROUGH SOLID-STATE FERMENTATION USING MACROMYCETES FUNGI 有权通过使用大肠杆菌真菌的固体发酵获得生物物质的生物反应器公开(公告)号：US20150197718A1
公开(公告)日：2015-07-16
申请号：US13865035
申请日：2013-04-17
摘要： Fixed bed bioreactor with natural convection and forced draught to obtain bioactive substances by solid-state fermentation (SEF) using fungi macromycetes. This bioreactor may be from turn drum with pendulum motion and natural and forced convection to a tray bioreactor with natural convection. They are used in the production of bioactive substances as crude extracts of lignocellulosic enzymes and fungal polysaccharides obtained by using mixtures of lignocellulosic materials as substrates and macromycetes fungi as inoculum, controlling pH, humidity and particle size, inoculation rate and environmental conditions during fermentation such as temperature, relative humidity and carbon dioxide and oxygen concentration.
摘要翻译： 具有自然对流和强制通风的固定床生物反应器通过使用真菌大肠杆菌的固态发酵（SEF）获得生物活性物质。 该生物反应器可以是具有摆动运动的转鼓和自然和强制对流到具有自然对流的塔板生物反应器。 它们用于生产生物活性物质，作为木质纤维素酶的粗提取物和通过使用木质纤维素材料作为底物和大肠杆菌真菌作为接种物的混合物获得的真菌多糖，控制pH，湿度和粒度，接种速率和发酵期间的环境条件，例如 温度，相对湿度和二氧化碳和氧气浓度。
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公开(公告)号：US08765449B2
公开(公告)日：2014-07-01
申请号：US13056841
申请日：2009-07-31
申请人： William C Stewart
发明人： William C Stewart
CPC分类号： C12M21/12 , B09C1/10 , C02F3/286 , C02F3/34 , C12M21/04 , C12M23/58 , C12M25/18 , C12M45/06 , C12P1/00 , C12P5/023 , Y02E50/343
摘要： A three stage, multiple phase anaerobic digestion system and method designed to separate the biological phases, optimize microbial activity in each phase, and significantly increase system reliability and energy production. The system physically separates the biological phases of anaerobic digestion based on particle size, particle density, and solubility of metabolic products. The system allows a complex multi-phased biological system to develop without the need for excessive control or operator intervention.
摘要翻译： 一个三相，多相厌氧消化系统和方法设计用于分离生物相，优化每相中的微生物活性，并显着提高系统的可靠性和能量生产。 该系统基于代谢产物的粒度，颗粒密度和溶解度物理地分离厌氧消化的生物相。 该系统允许复杂的多阶段生物系统开发而无需过度控制或操作员干预。
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公开(公告)号：US20130337527A1
公开(公告)日：2013-12-19
申请号：US13932981
申请日：2013-07-01
申请人： David C. Walther , Hendrik J. Meerman , Stacy M. Burns-Guydish , Richard W. Wilson , Eamon T. Hogg , Gregory W. Luli , Robert Eckert
发明人： David C. Walther , Hendrik J. Meerman , Stacy M. Burns-Guydish , Richard W. Wilson , Eamon T. Hogg , Gregory W. Luli , Robert Eckert
IPC分类号： C12M1/00
CPC分类号： C12M21/12 , C12M23/58 , C12M25/18 , C12M25/20 , C12M43/02 , C12M45/06 , C12M47/10 , C12P7/065 , C12P7/16 , C12P7/28 , Y02E50/10 , Y02E50/17 , Y02P20/582
摘要： Processes and systems for production of bioproducts such as biofuels are provided. The bioproduct production processes and systems utilize pretreatment of a carbohydrate-containing feedstock to produce soluble sugar molecules and continuous conversion of the pretreated feedstock to a bioproduct by an immobilized fermenting microorganism.
摘要翻译： 提供生物制品生产过程和系统，如生物燃料。 生物产品生产过程和系统利用含碳水化合物的原料的预处理以产生可溶性糖分子，并通过固定的发酵微生物将预处理的原料连续转化成生物产物。
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10.发明申请Ensiling Biomass for Biofuels Production and Multiple Phase Apparatus for Hydolyzation of Ensiled Biomass 审中-公开生物燃料的生物质生产和多相装置用于水生生物质的水解公开(公告)号：US20130323830A1
公开(公告)日：2013-12-05
申请号：US13947368
申请日：2013-07-22
发明人： Jerry Wayne Horton
IPC分类号： C12M1/00
CPC分类号： C12M21/00 , C12M21/12 , C12M21/16 , C12M25/18 , C12M43/02 , C12M45/06 , C12M45/09 , C12M45/20 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： A method, apparatus and system for the hydrolyzation of ensiled biomass is disclosed. Ensiled biomass is processed in multiple phases, resulting in a liquid precursor hydrozate and a solid precursor hydrozate. The liquid precursor having significant economic value, and being suitable for uses such as, for example, lower cost and improved efficiency ethanol production. A method for lower cost, improved efficiency alcohol production that uses the resulting liquid precursor hydrozate being produced at distributed sources is further disclosed.
摘要翻译： 公开了一种用于水解生物量的方法，装置和系统。 将多种生物质多相加工，得到液体前体氢化物和固体前体氢化物。 液体前体具有显着的经济价值，适用于例如较低成本和改进乙醇生产效率等用途。 进一步公开了一种降低成本，改进使用在分布式源产生的液体前体氢化物的效率酒精生产的方法。
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