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    Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof
    1.
    发明申请
    Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof 审中-公开
    Hmgb1的拮抗剂和/或愤怒及其使用方法

    公开(公告)号：US20080311122A1

    公开(公告)日：2008-12-18

    申请号：US12094449

    申请日：2006-11-27

    申请人： Herren Wu ,  Ling-Ling An ,  Peter Kiener ,  Anthony Coyle ,  Jane Tian ,  Changsou Gao

    发明人： Herren Wu ,  Ling-Ling An ,  Peter Kiener ,  Anthony Coyle ,  Jane Tian ,  Changsou Gao

    IPC分类号： A61K39/395 ,  A61K31/7105 ,  A61P37/02

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/32

    摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, lupus, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

    摘要翻译： 公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。 组合物包含例如特异性结合HMG1的高亲和力抗体及其抗原性片段。 本发明的高亲和力抗体和包含其的药物组合物可用于许多目的，例如作为针对广泛范围的炎性疾病和病症的治疗剂，例如败血症，类风湿性关节炎，腹膜炎，克罗恩病，再灌注损伤， 败血病，内毒素性休克，囊性纤维化，心内膜炎，狼疮，牛皮癣，牛皮癣关节炎，关节炎，过敏性休克，器官缺血，再灌注损伤和同种异体移植排斥。 此外，本发明的高亲和力抗体可用作诊断抗体。