公开(公告)号：US4385050A

公开(公告)日：1983-05-24

申请号：US277497

申请日：1981-06-26

Applicant: Karl Lederis ,  David Stevenson ,  Donald B. Olsen ,  Charles D. Bossinger ,  Everett Flanigan

Inventor： Karl Lederis ,  David Stevenson ,  Donald B. Olsen ,  Charles D. Bossinger ,  Everett Flanigan

IPC: A61K38/00 ,  C07K14/575 ,  A61K37/00 ,  C07C103/52

CPC classification number: C07K14/57509 ,  A61K38/00 ,  Y10S530/80

Abstract: Peptides of the structureR.sub.1 --Ala--Arg--Ile--Glu--Asn--Glu--Glu--Glu--Gln--Ala--Gly--Leu--Asn--Arg--Lys--Tyr--Leu--Val--R.sub.2whereinR.sub.1 is hydrogen, a peptide residue containing from 1 to 18 amino acid residues, or N-acyl, andR.sub.2 is hydrogen, an alcohol moiety of an ester, an amide, or a peptide residue containing from 1 to 10 amino acid residues,whereinthe acyl group is lower alkanoyl having from 1 to 8 carbon atoms, aroyl, or heterocarbonyl, and the alcohol moiety of the ester is an alkyl group having from 1 to 8 carbon atoms have antihypertensive activity.

Abstract translation: 结构R1-Ala-Arg-Ile-Glu-Asn-Glu-Glu-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu -Val-R2的肽，其中R1是氢，肽 含有1至18个氨基酸残基的残基或N-酰基，R2是氢，含有1至10个氨基酸残基的酯，酰胺或肽残基的醇部分，其中酰基是低级烷酰基 具有1至8个碳原子，芳酰基或杂羰基，并且酯的醇部分是具有1至8个碳原子的烷基具有抗高血压活性。

公开(公告)号：US4242238A

公开(公告)日：1980-12-30

申请号：US657753

申请日：1976-02-13

Applicant: Robert L. Colescott ,  Emil Kaiser ,  Charles D. Bossinger

Inventor： Robert L. Colescott ,  Emil Kaiser ,  Charles D. Bossinger

IPC: A61K38/00 ,  C07K14/695 ,  C08L37/00 ,  A61K37/00 ,  C07C103/52

CPC classification number: C07K14/695 ,  A61K38/00 ,  Y10S930/28

Abstract: Resin peptides useful in preparing peptides having biological activity, and particularly such resin peptides containing ALA-GLU-CH.sub.2 - R at one end of an amino acid chain, R being the resin and ALA and GLU being the residues of the amino acids alanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides including ACTH.sup.1-28 are disclosed which have adrenocorticotropic activity along with processes for their preparation.

Abstract translation: 可用于制备具有生物活性的肽的树脂肽，特别是在氨基酸链的一端含有ALA-GLU-CH2-R的树脂肽，R为树脂，ALA和GLU为氨基酸丙氨酸和谷氨酸的残基 酸; 以及制备这种树脂肽的方法。 公开了包括ACTH1-28的树脂肽，其具有促肾上腺皮质活性及其制备方法。

公开(公告)号：US4055524A

公开(公告)日：1977-10-25

申请号：US603771

申请日：1975-08-11

Applicant: Robert L. Colescott ,  Emil Kaiser ,  Charles D. Bossinger ,  Paul I. Cook

Inventor： Robert L. Colescott ,  Emil Kaiser ,  Charles D. Bossinger ,  Paul I. Cook

IPC: A61K38/00 ,  C07K1/04 ,  C07K14/695 ,  C08F8/30 ,  C08H1/00 ,  C08L89/00 ,  C07C103/52

CPC classification number: C08H1/00 ,  C07K1/042 ,  C07K14/695 ,  C08F8/30 ,  A61K38/00 ,  Y10S930/28

Abstract: Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R-CH.sub.2 -Phe-Glu at one end of an amino acid chain, R being the resin and Phe and Glu being the residues of the amino acids phenylalanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

Abstract translation: 可用于制备具有生物活性的肽的树脂肽，特别是在氨基酸链一端含有R-CH2-Phe-Glu的树脂肽，R为树脂，Phe和Glu为氨基酸苯丙氨酸的残基 和谷氨酸; 以及制备这种树脂肽的方法。 公开了含有与具有生物活性的天然肽的氨基酸链相同的氨基酸链的树脂肽。 公开了其中含有氨基酸残基的氨基酸残基的其它树脂肽，其中氨基酸残基的种类和序列与天然生物活性肽的氨基酸序列不同，但可以衍生出具有生物活性的肽。