公开(公告)号：US20120270924A1

公开(公告)日：2012-10-25

申请号：US13477825

申请日：2012-05-22

申请人： Charlotte Albæk Thrue ,  Anja Mølhart Høg ,  Paul E.G. Kristjansen

发明人： Charlotte Albæk Thrue ,  Anja Mølhart Høg ,  Paul E.G. Kristjansen

IPC分类号： A61K31/712 ,  A61P37/02 ,  A61P31/12 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K31/7088 ,  A61K31/70 ,  A61K38/00 ,  A61K45/06 ,  C07H21/04 ,  C12N15/113 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/331 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/335 ,  C12N2310/341 ,  A61K2300/00

摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.

摘要翻译： 提供针对缺氧诱导因子-1α（HIF-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。

公开(公告)号：US07713738B2

公开(公告)日：2010-05-11

申请号：US10776934

申请日：2004-02-10

申请人： Bo Hansen ,  Charlotte Albæk Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

发明人： Bo Hansen ,  Charlotte Albæk Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

IPC分类号： C12N5/00

CPC分类号： C07H21/04

摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

公开(公告)号：US07737264B2

公开(公告)日：2010-06-15

申请号：US10407807

申请日：2003-04-04

申请人： Charlotte Albæk Thrue ,  Anja Mølhart Høg ,  Paul E. G. Kristjansen

发明人： Charlotte Albæk Thrue ,  Anja Mølhart Høg ,  Paul E. G. Kristjansen

IPC分类号： C07H21/04

CPC分类号： A61K31/7088 ,  A61K31/70 ,  A61K38/00 ,  A61K45/06 ,  C07H21/04 ,  C12N15/113 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/331 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/335 ,  C12N2310/341 ,  A61K2300/00

摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.

摘要翻译： 提供针对缺氧诱导因子-1α（HIF-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。