公开(公告)号：US07803350B2

公开(公告)日：2010-09-28

申请号：US11881901

申请日：2007-07-30

申请人： Te-Wei Lee ,  Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shiang-Rong Chang ,  Shyh-Yi Chyi ,  Chih-Hsien Chang ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao

发明人： Te-Wei Lee ,  Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shiang-Rong Chang ,  Shyh-Yi Chyi ,  Chih-Hsien Chang ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao

IPC分类号： A61K51/00 ,  A61K36/14

CPC分类号： A61K51/02 ,  A61K41/009 ,  A61K51/121

摘要： This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i).This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.

摘要翻译： 本发明提供一种放射性含砷化合物的制造方法，其特征在于，包括以下工序：（i）对含砷化合物进行中子照射处理，所述含砷化合物选自As2O3，As2S3， As2S2及其组合，使含砷化合物中所含的砷元素转化为放射性砷同位素; 和（ii）从步骤（i）中回收所得产物。 本发明还提供包含治疗有效量的放射性含砷化合物和药学上可接受的载体的药物组合物。 药物组合物可用于治疗肿瘤/癌症如血液恶性肿瘤和实体瘤。

公开(公告)号：US20080003177A1

公开(公告)日：2008-01-03

申请号：US11881901

申请日：2007-07-30

申请人： Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Wei Lee ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shyh-Yi Chyi ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao ,  Shiang-Rong Chang ,  Chih-Hsien Chang

发明人： Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Wei Lee ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shyh-Yi Chyi ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao ,  Shiang-Rong Chang ,  Chih-Hsien Chang

IPC分类号： A61K51/02 ,  A61P35/00

CPC分类号： A61K51/02 ,  A61K41/009 ,  A61K51/121

摘要： This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i). This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.

摘要翻译： 本发明提供了一种制备放射性含砷化合物的方法，包括以下步骤：（i）对含砷化合物进行中子照射处理，所述含砷化合物选自： 2 3 3 3 3 SUB>及其组合，使含砷化合物中所含的砷元素转化为放射性砷同位素; 和（ii）从步骤（i）中回收所得产物。 本发明还提供包含治疗有效量的放射性含砷化合物和药学上可接受的载体的药物组合物。 药物组合物可用于治疗肿瘤/癌症如血液恶性肿瘤和实体瘤。