公开(公告)号：US07854090B2

公开(公告)日：2010-12-21

申请号：US11478680

申请日：2006-07-03

申请人： Yean-Chang Chen ,  Chia-Chieh Chen ,  Kuan-Yin Chen ,  Hsueh-Hsuan Liu ,  Bin Lin ,  Meng-Chou Lee ,  Ming-Chao Kuo ,  Wen-Song Hwang ,  Ying-Kai Fu ,  Wuu-Jyh Lin ,  Lie-Hang Shen

发明人： Yean-Chang Chen ,  Chia-Chieh Chen ,  Kuan-Yin Chen ,  Hsueh-Hsuan Liu ,  Bin Lin ,  Meng-Chou Lee ,  Ming-Chao Kuo ,  Wen-Song Hwang ,  Ying-Kai Fu ,  Wuu-Jyh Lin ,  Lie-Hang Shen

IPC分类号： A01H13/00

CPC分类号： A01G33/00 ,  A01H3/00 ,  Y02A40/88

摘要： Through a low-dose irradiation, a seaweed's growth becomes fast and its production is improved as well. By doing so, a material for biomass energy is provided.

摘要翻译： 通过低剂量照射，海藻的生长变快，生产也得到改善。 通过这样做，提供了用于生物质能的材料。

公开(公告)号：US20080005959A1

公开(公告)日：2008-01-10

申请号：US11480440

申请日：2006-07-05

申请人： Chia-Chieh Chen ,  Yean-Chang Chen ,  Kuan-Yin Chen ,  Hsueh-Hsuan Liu ,  Bin Lin ,  Meng-Chou Lee ,  Ming-Chao Ku ,  Wen-Song Hwang ,  Ying-Kai Fu ,  Wuu-Jyh Lin ,  Lie-Hang Shen

发明人： Chia-Chieh Chen ,  Yean-Chang Chen ,  Kuan-Yin Chen ,  Hsueh-Hsuan Liu ,  Bin Lin ,  Meng-Chou Lee ,  Ming-Chao Ku ,  Wen-Song Hwang ,  Ying-Kai Fu ,  Wuu-Jyh Lin ,  Lie-Hang Shen

IPC分类号： A01H13/00

CPC分类号： A01G33/00 ,  Y02A40/88

摘要： A wild seaweed, like sea lettuce, is picked and germ cells are released from the seaweed. The germ cells then obtain adherence and are sprouted into youngs of the seaweed so that the seaweed can be cultivated artificially and productively and can be supplied as a material for biomass energy.

摘要翻译： 采摘野生海藻，如海生莴苣，生殖细胞从海藻中释放出来。 然后，生殖细胞获得粘附性，并且被发芽成为海藻的幼体，使得海藻可以人工和生产地培养并且可以作为生物质能的材料提供。

公开(公告)号：US07803350B2

公开(公告)日：2010-09-28

申请号：US11881901

申请日：2007-07-30

申请人： Te-Wei Lee ,  Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shiang-Rong Chang ,  Shyh-Yi Chyi ,  Chih-Hsien Chang ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao

发明人： Te-Wei Lee ,  Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shiang-Rong Chang ,  Shyh-Yi Chyi ,  Chih-Hsien Chang ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao

IPC分类号： A61K51/00 ,  A61K36/14

CPC分类号： A61K51/02 ,  A61K41/009 ,  A61K51/121

摘要： This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i).This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.

摘要翻译： 本发明提供一种放射性含砷化合物的制造方法，其特征在于，包括以下工序：（i）对含砷化合物进行中子照射处理，所述含砷化合物选自As2O3，As2S3， As2S2及其组合，使含砷化合物中所含的砷元素转化为放射性砷同位素; 和（ii）从步骤（i）中回收所得产物。 本发明还提供包含治疗有效量的放射性含砷化合物和药学上可接受的载体的药物组合物。 药物组合物可用于治疗肿瘤/癌症如血液恶性肿瘤和实体瘤。

公开(公告)号：US07712250B2

公开(公告)日：2010-05-11

申请号：US11480440

申请日：2006-07-05

申请人： Yean-Chang Chen ,  Chia-Chieh Chen ,  Kuan-Yin Chen ,  Hsueh-Hsuan Liu ,  Bin Lin ,  Meng-Chou Lee ,  Ming-Chao Kuo ,  Wen-Song Hwang ,  Ying-Kai Fu ,  Wuu-Jyh Lin ,  Lie-Hang Shen

发明人： Yean-Chang Chen ,  Chia-Chieh Chen ,  Kuan-Yin Chen ,  Hsueh-Hsuan Liu ,  Bin Lin ,  Meng-Chou Lee ,  Ming-Chao Kuo ,  Wen-Song Hwang ,  Ying-Kai Fu ,  Wuu-Jyh Lin ,  Lie-Hang Shen

IPC分类号： A01H13/00

CPC分类号： A01G33/00 ,  Y02A40/88

摘要： A wild seaweed, like sea lettuce, is picked and germ cells are released from the seaweed. The germ cells then obtain adherence and are sprouted into youngs of the seaweed so that the seaweed can be cultivated artificially and productively and can be supplied as a material for biomass energy.

摘要翻译： 采摘野生海藻，如海生莴苣，生殖细胞从海藻中释放出来。 然后，生殖细胞获得粘附性，并且被发芽成为海藻的幼体，使得海藻可以人工和生产地培养并且可以作为生物质能的材料提供。

公开(公告)号：US07638338B2

公开(公告)日：2009-12-29

申请号：US11119215

申请日：2005-04-29

申请人： Kung-Tien Liu ,  Jyh-Perng Chiu ,  Hsuan-Erh Chao ,  Ying-Kai Fu

发明人： Kung-Tien Liu ,  Jyh-Perng Chiu ,  Hsuan-Erh Chao ,  Ying-Kai Fu

IPC分类号： G01N33/00

CPC分类号： G01F25/0092 ,  G01F1/7042 ,  G01N35/1016 ,  G01N2035/1034 ,  Y10T436/13

摘要： The present invention provides a method for measuring and calibrating sample injection volume or mobile phase delivery rate of any type of micropumps or their integrated systems by using the direct proportion of the total activity (or mass) to the delivery rate (or volume) of a radiochemical nuclide with known activity in a certain time period. Also, the present invention may adjust the range of measurement and calibration from micro-liter (μL) to pico-liter (pL) or from μL/min to pL/min by selecting nuclide species and their concentrations from different liquid calibration radiation sources.

摘要翻译： 本发明提供了一种用于通过使用总活度（或质量）与总活性（或​​体积）的直接比例相比，来测量和校准任何类型的微型泵或其集成系统的样品进样体积或流动相递送速率的方法， 放射化学核素在一定时间内具有已知活性。 此外，本发明可以通过从不同的液体校准辐射源中选择核素种类及其浓度，将测量和校准的范围从微升（μL）调整到微升（pL）或从muL / min调节到pL / min。

公开(公告)号：US20070042502A1

公开(公告)日：2007-02-22

申请号：US11161888

申请日：2005-08-21

申请人： Kung Tien Liu ,  Yi Chih Hsia ,  Chang Yung Su ,  Chiung Fang Huang ,  Ying Kai Fu

发明人： Kung Tien Liu ,  Yi Chih Hsia ,  Chang Yung Su ,  Chiung Fang Huang ,  Ying Kai Fu

IPC分类号： G01N30/02

CPC分类号： G01N30/88 ,  G01N30/7233 ,  G01N2030/027 ,  G01N2030/8809 ,  Y10T436/25375

摘要： This invention discloses a novel technology for the impurities assay of TRODAT-1 raw material by reverse phase high performance liquid chromatography (RP-HPLC). The method for TRODAT-1 raw material impurities assay of this present invention includes using high performance liquid chromatography (HPLC), liquid chromatography tandem mass spectrometry (LC-MS/MS), HPLC column, preparation of samples, regents and eluent as well as performing parent and product ion analysis by mass spectrometry for the method validation, calculation of chromatographic resolution and raw material impurities. This invention is the first report in the world that proved the existence of oligomers in TRODAT-1 raw material, as well as an analytical method through elaborated validation procedures to quantify the impurities (including the oligomers) in TRODAT-1 raw material.

摘要翻译： 本发明公开了通过反相高效液相色谱（RP-HPLC）对TRODAT-1原料进行杂质测定的新技术。 本发明的TRODAT-1原料杂质测定方法包括使用高效液相色谱（HPLC），液相色谱串联质谱（LC-MS / MS），HPLC柱，样品制备，试剂和洗脱液以及 通过质谱法进行母体和产品离子分析，进行方法验证，计算色谱分离度和原料杂质。 本发明是世界上第一份证明TRODAT-1原料中低聚物存在的报告，以及通过详细验证程序对TRODAT-1原料中杂质（包括低聚物）进行定量的分析方法。

公开(公告)号：US20060292207A1

公开(公告)日：2006-12-28

申请号：US11158058

申请日：2005-06-22

申请人： Te-Hsing Wu ,  Jen-Ming Yang ,  Ying-Kai Fu ,  Hao-Tzu Lin ,  Chia-Chieh Chen

发明人： Te-Hsing Wu ,  Jen-Ming Yang ,  Ying-Kai Fu ,  Hao-Tzu Lin ,  Chia-Chieh Chen

IPC分类号： A61L15/00 ,  A61K31/722

CPC分类号： A61K31/722 ,  A61L15/28 ,  A61L15/42 ,  C08L5/08

摘要： The present invention is a dressing capable of hydrotaxis and temperature-sensitivity for a wound or for antisepsis, containing layers of acrylic acid, N-isopropyl acrylamide and chitosan by a grafting through an ionizing radiation, a UV radiation, a peracid process and a freeze-drying process.

摘要翻译： 本发明是一种能够通过电离辐射，紫外线辐射，过酸过程和冷冻接枝的含有丙烯酸，N-异丙基丙烯酰胺和壳聚糖层的用于伤口或消毒的加氢变性和温度敏感性的敷料 干燥过程

公开(公告)号：US20060051242A1

公开(公告)日：2006-03-09

申请号：US11119215

申请日：2005-04-29

申请人： Kung-Tien Liu ,  Jyh-Perng Chiu ,  Hsuan-Erh Chao ,  Ying-Kai Fu

发明人： Kung-Tien Liu ,  Jyh-Perng Chiu ,  Hsuan-Erh Chao ,  Ying-Kai Fu

IPC分类号： G01N33/48

CPC分类号： G01F25/0092 ,  G01F1/7042 ,  G01N35/1016 ,  G01N2035/1034 ,  Y10T436/13

摘要： The present invention provides a method for measuring and calibrating sample injection volume or mobile phase delivery rate of any type of micropumps or their integrated systems by using the direct proportion of the total activity (or mass) to the delivery rate (or volume) of a radiochemical nuclide with known activity in a certain time period. Also, the present invention may adjust the range of measurement and calibration from micro-liter (μL) to pico-liter (pL) or from μL/min to pL/min by selecting nuclide species and their concentrations from different liquid calibration radiation sources.

公开(公告)号：US20100216207A1

公开(公告)日：2010-08-26

申请号：US11979097

申请日：2007-10-30

申请人： Yean-Chang Chen ,  Kuan-Yin Chen ,  Chia-Chieh Chen ,  Bin Lin ,  Hsueh-Hsuan Liu ,  Meng-Chou Lee ,  Wuu-Jyh Lin ,  Ying-Kai Fu ,  Lie-Hang Shen ,  Wen-Song Hwang ,  Ming-Chao Kuo ,  Wei-Hsi Chen ,  Te-Hsing Wu

发明人： Yean-Chang Chen ,  Kuan-Yin Chen ,  Chia-Chieh Chen ,  Bin Lin ,  Hsueh-Hsuan Liu ,  Meng-Chou Lee ,  Wuu-Jyh Lin ,  Ying-Kai Fu ,  Lie-Hang Shen ,  Wen-Song Hwang ,  Ming-Chao Kuo ,  Wei-Hsi Chen ,  Te-Hsing Wu

IPC分类号： C12N13/00 ,  C12M1/12

CPC分类号： C12N1/36 ,  A01G33/00 ,  C12N1/12 ,  C12N13/00 ,  Y02A40/88

摘要： An apparatus is disclosed for growing algae by ionizing radiation. The apparatus includes a container for containing medium for the growth of algae, a filter disposed in the container, a 3-dimensional rack disposed in the container, an adherent element wound on the 3-dimension rack so that spores of the algae can be planted in the adherent element, a radiation element disposed in the container for irradiating the spores and a timepiece connected to the radiation element.

摘要翻译： 公开了通过电离辐射来生长藻类的装置。 该装置包括用于容纳藻类生长的容器的容器，设置在容器中的过滤器，设置在容器中的3维齿条，缠绕在3维齿条上的粘附元件，以便能种植藻类的孢子 在粘合元件中，设置在容器中用于照射孢子的辐射元件和连接到辐射元件的钟表。

公开(公告)号：US20080003177A1

公开(公告)日：2008-01-03

申请号：US11881901

申请日：2007-07-30

申请人： Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Wei Lee ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shyh-Yi Chyi ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao ,  Shiang-Rong Chang ,  Chih-Hsien Chang

发明人： Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Wei Lee ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shyh-Yi Chyi ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao ,  Shiang-Rong Chang ,  Chih-Hsien Chang

IPC分类号： A61K51/02 ,  A61P35/00

CPC分类号： A61K51/02 ,  A61K41/009 ,  A61K51/121

摘要： This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i). This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.

摘要翻译： 本发明提供了一种制备放射性含砷化合物的方法，包括以下步骤：（i）对含砷化合物进行中子照射处理，所述含砷化合物选自： 2 3 3 3 3 SUB>及其组合，使含砷化合物中所含的砷元素转化为放射性砷同位素; 和（ii）从步骤（i）中回收所得产物。 本发明还提供包含治疗有效量的放射性含砷化合物和药学上可接受的载体的药物组合物。 药物组合物可用于治疗肿瘤/癌症如血液恶性肿瘤和实体瘤。