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1.发明授权Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti-adhesion barriers and anti-thrombotic materials 有权用聚乙二醇作为抗粘连屏障和抗血栓形成材料的丝素蛋白基质的表面改性公开(公告)号：US09427499B2
公开(公告)日：2016-08-30
申请号：US13129738
申请日：2009-11-17
申请人： Charu P. Vepari , David L. Kaplan
发明人： Charu P. Vepari , David L. Kaplan
CPC分类号： A61L31/005 , A61L31/10 , A61L33/068 , C08L71/02
摘要： The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be used in biomedical applications, such as anti-adhesive and anti-thrombosis materials. Silk matrices may be surface-PEGylated, for example, by a reaction with a functional group-activated PEG. Controlling the degree of PEGylation on surface of silk fibroin matrix can regulate both the degradation rate of the silk matrix, and the differentiated adhesion of cells or differentiated adsorption of proteins on the surface of the silk matrix. The present invention also provides for silk fibroin matrices having one or more surfaces possessing differentiated adhesion properties, which allows for tissue integration on the adherent side and inhibition of tissue adhesion to the opposing tissues or organs. Embedding active agents in silk fibroin matrices provides more benefits, such as promoting tissue ingrowth on the adherent side of the matrix.
摘要翻译： 本发明提供了用于生产在一个或多个表面上表面聚乙二醇化的丝素蛋白基质的组合物和方法。 这种表面聚乙二醇化的丝素蛋白基质可用于生物医学应用，例如抗粘连和抗血栓形成的材料。 丝质基质可以被表面聚乙二醇化，例如通过与官能团活化的PEG的反应。 控制丝素蛋白基质表面聚乙二醇化程度可以调节蚕丝基质的降解速率，分化细胞粘附或蛋白质在丝质基质表面的分化吸附。 本发明还提供具有一个或多个具有分化的粘附性质的表面的丝素蛋白基质，其允许组合物在粘附层上的整合并抑制组织对相对组织或器官的粘附。 在丝素蛋白基质中包埋活性剂提供了更多的益处，例如促进组织向上生长在基质的粘着面上。
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2.发明申请SURFACE MODIFICATION OF SILK FIBROIN MATRICES WITH POLY(ETHYLENE GLYCOL) USEFUL AS ANTI-ADHESION BARRIERS AND ANTI-THROMBOTIC MATERIALS 有权具有聚（乙二醇）的丝状纤维素基质的表面改性作为抗粘连剂和抗生素材料有用公开(公告)号：US20120076771A1
公开(公告)日：2012-03-29
申请号：US13129738
申请日：2009-11-17
申请人： Charu P. Vepari , David L. Kaplan
发明人： Charu P. Vepari , David L. Kaplan
IPC分类号： A61K47/42 , A61K35/00 , A61K38/16 , A61K38/02 , A61K31/7088 , A61P17/02 , A61K39/395 , A61K38/19 , A61K38/43 , A61K35/76 , A61P7/02 , C07K14/78 , A61K31/7052
CPC分类号： A61L31/005 , A61L31/10 , A61L33/068 , C08L71/02
摘要： The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be used in biomedical applications, such as anti-adhesive and anti-thrombosis materials. Silk matrices may be surface-PEGylated, for example, by a reaction with a functional group-activated PEG. Controlling the degree of PEGylation on surface of silk fibroin matrix can regulate both the degradation rate of the silk matrix, and the differentiated adhesion of cells or differentiated adsorption of proteins on the surface of the silk matrix. The present invention also provides for silk fibroin matrices having one or more surfaces possessing differentiated adhesion properties, which allows for tissue integration on the adherent side and inhibition of tissue adhesion to the opposing tissues or organs. Embedding active agents in silk fibroin matrices provides more benefits, such as promoting tissue ingrowth on the adherent side of the matrix.
摘要翻译： 本发明提供了用于生产在一个或多个表面上表面聚乙二醇化的丝素蛋白基质的组合物和方法。 这种表面聚乙二醇化的丝素蛋白基质可用于生物医学应用，例如抗粘连和抗血栓形成的材料。 丝质基质可以被表面聚乙二醇化，例如通过与官能团活化的PEG的反应。 控制丝素蛋白基质表面聚乙二醇化程度可以调节蚕丝基质的降解速率，分化细胞粘附或蛋白质在丝质基质表面的分化吸附。 本发明还提供具有一个或多个具有分化的粘附性质的表面的丝素蛋白基质，其允许组合物在粘附层上的整合并抑制组织对相对组织或器官的粘附。 在丝素蛋白基质中包埋活性剂提供了更多的益处，例如促进组织向上生长在基质的粘着面上。
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