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公开(公告)号：US20050008721A1
公开(公告)日：2005-01-13
申请号：US10915464
申请日：2004-08-11
Applicant: Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
Inventor： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
CPC classification number: A61K36/69 , A61K2300/00
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
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2.发明申请公开(公告)号：US20090104293A1
公开(公告)日：2009-04-23
申请号：US11907854
申请日：2007-10-18
Applicant: Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
Inventor： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
IPC: A61K36/9068 , A61P43/00
CPC classification number: A61K36/9068
Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.
Abstract translation: 本发明公开了一种从姜黄根提取的有效产品在治疗与幽门螺杆菌相关的疾病如胃炎，胃溃疡或十二指肠溃疡中的新用途。 所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入反相层析柱，并用极性低于水的第一洗脱液洗脱柱，以获得极性低于第一洗脱液的第一有效级分或第二洗脱液，从而获得 第二有效分数。 优选地，第二有效级分基本上不含6-姜醇和6-shogaol。
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3.发明授权公开(公告)号：US07179496B2
公开(公告)日：2007-02-20
申请号：US10915464
申请日：2004-08-11
Applicant: Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
Inventor： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
IPC: A61K35/78
CPC classification number: A61K36/69 , A61K2300/00
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
Abstract translation: 药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物 的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。
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公开(公告)号：US06911222B2
公开(公告)日：2005-06-28
申请号：US10335920
申请日：2003-01-03
Applicant: Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
Inventor： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
CPC classification number: A61K36/69 , A61K2300/00
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
Abstract translation: 药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物 的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。
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公开(公告)号：US07223425B2
公开(公告)日：2007-05-29
申请号：US10915462
申请日：2004-08-11
Applicant: Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
Inventor： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
IPC: A61K36/00
CPC classification number: A61K36/69 , A61K2300/00
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
Abstract translation: 药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物 的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08470379B2
公开(公告)日：2013-06-25
申请号：US12911143
申请日：2010-10-25
Applicant: Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
Inventor： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
IPC: A61K36/9068
CPC classification number: A61K36/9068
Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.
Abstract translation: 从姜黄根茎提取的有效产品的新用途，用于治疗与幽门螺杆菌相关的疾病，如胃炎，胃溃疡或十二指肠溃疡。 所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入正相色谱柱，并用具有极性低于正己烷和乙酸乙酯的混合物的第一洗脱液以6:4的重量比洗脱柱，以获得有效分数 。 优选地，有效部分基本上不含6-姜醇和6-硫醇。
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公开(公告)号：US07175861B2
公开(公告)日：2007-02-13
申请号：US10915445
申请日：2004-08-11
Applicant: Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
Inventor： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
IPC: A61K35/78
CPC classification number: A61K36/69 , A61K2300/00
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
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8.发明申请公开(公告)号：US20050008719A1
公开(公告)日：2005-01-13
申请号：US10915445
申请日：2004-08-11
Applicant: Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
Inventor： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
CPC classification number: A61K36/69 , A61K2300/00
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
Abstract translation: 药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物 的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。
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9.发明申请USE OF A POTENT PRODUCT EXTRACTED FROM RHIZOMES OF ZINGIBER OFFICINALE IN TREATING A DISEASE ASSOCIATED WITH HELICOBACTER PYLORI 有权在治疗与HELICOBACTER PYLORI相关的疾病中使用从ZINGIBER OFFICINALE的RHIZOMES提取的产品公开(公告)号：US20110038966A1
公开(公告)日：2011-02-17
申请号：US12911143
申请日：2010-10-25
Applicant: Feng-Nien KO , Mo-Chi CHENG , Cheng-Ko LIU , Jen-Wei CHEN , Fen CHEN , Chao-Chi YEI
Inventor： Feng-Nien KO , Mo-Chi CHENG , Cheng-Ko LIU , Jen-Wei CHEN , Fen CHEN , Chao-Chi YEI
IPC: A61K36/906 , A61P1/04
CPC classification number: A61K36/9068
Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.
Abstract translation: 从姜黄根茎提取的有效产品的新用途，用于治疗与幽门螺杆菌相关的疾病，如胃炎，胃溃疡或十二指肠溃疡。 所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入正相色谱柱，并用具有极性低于正己烷和乙酸乙酯的混合物的第一洗脱液以6:4的重量比洗脱柱，以获得有效分数 。 优选地，有效部分基本上不含6-姜醇和6-硫醇。
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10.发明授权公开(公告)号：US07842318B2
公开(公告)日：2010-11-30
申请号：US11907854
申请日：2007-10-18
Applicant: Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
Inventor： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
IPC: A61K36/9068
CPC classification number: A61K36/9068
Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.
Abstract translation: 本发明公开了一种从姜黄根提取的有效产品在治疗与幽门螺杆菌相关的疾病如胃炎，胃溃疡或十二指肠溃疡中的新用途。 所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入反相层析柱，并用极性低于水的第一洗脱液洗脱柱，以获得极性低于第一洗脱液的第一有效级分或第二洗脱液，从而获得 第二有效分数。 优选地，第二有效级分基本上不含6-姜醇和6-shogaol。
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