公开(公告)号：US08278285B2

公开(公告)日：2012-10-02

申请号：US12594843

申请日：2008-08-06

申请人： Nam-Soon Kim ,  In-Sung Song ,  Nang-Su Oh ,  So-Young Jeong ,  Ga-Hee Ha ,  Yeo-Jin Jeon ,  Jeong-Min Kim ,  Cheol-Hee Kim ,  Hyun-Taek Kim

发明人： Nam-Soon Kim ,  In-Sung Song ,  Nang-Su Oh ,  So-Young Jeong ,  Ga-Hee Ha ,  Yeo-Jin Jeon ,  Jeong-Min Kim ,  Cheol-Hee Kim ,  Hyun-Taek Kim

IPC分类号： A61K31/70 ,  C07H21/04

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.

摘要翻译： 本发明涉及含有ZNF312b基因及其片段的诊断标记物，胃癌的诊断方法以及使用其的胃癌诱导剂或抑制剂的筛选方法。 ZNF312b基因表达在胃癌中特异性增加。 并且该基因的过表达或低表达影响胃癌细胞系和细胞增殖信号转导系统的细胞增殖和肿瘤形成的激活或抑制，并最终诱导胃癌。 因此，ZNF312b标记基因可以有效地用于胃癌的诊断，胃癌动物模型的建立，胃癌的预防和治疗以及胃癌特异性抗癌剂的开发。

公开(公告)号：US20120085632A1

公开(公告)日：2012-04-12

申请号：US13222040

申请日：2011-08-31

申请人： Soo-Hyun LEE ,  Seok-Gyu LEE ,  Cheol-Hee KIM

发明人： Soo-Hyun LEE ,  Seok-Gyu LEE ,  Cheol-Hee KIM

IPC分类号： H01H13/76 ,  H01H9/00

CPC分类号： H01H13/83 ,  G02B6/0043 ,  G02B6/006 ,  H01H2209/002 ,  H01H2209/082 ,  H01H2219/034 ,  H01H2219/056 ,  H01H2219/06 ,  H01H2219/062 ,  H01H2221/07

摘要： Provided is a keypad apparatus for a portable communication device structured to have a Printed Circuit Board (PCB) including a plurality of dome switches and a plurality of Light-Emitting Diodes (LEDs). The keypad apparatus includes a waveguide sheet portion provided on the dome switches, a plurality of printed surfaces which are printed on a top surface of the waveguide sheet portion and adjust a brightness of light from the LEDs, in a stepwise manner from a position distant from the LEDs to a position adjacent to the LEDs, and a keypad provided on the printed surfaces.

摘要翻译： 提供了一种用于便携式通信设备的键盘装置，其被构造为具有包括多个圆顶开关和多个发光二极管（LED）的印刷电路板（PCB）。 键盘装置包括设置在圆顶开关上的波导片部分，多个印刷表面，印刷在波导片部分的顶表面上，并从远离的位置以逐步的方式调节来自LED的光的亮度。 LED到与LED相邻的位置，以及设置在印刷表面上的键盘。

公开(公告)号：US20120193206A1

公开(公告)日：2012-08-02

申请号：US13361168

申请日：2012-01-30

申请人： Soo-Hyun LEE ,  Seok-Gyu LEE ,  Cheol-Hee KIM

发明人： Soo-Hyun LEE ,  Seok-Gyu LEE ,  Cheol-Hee KIM

IPC分类号： H01H13/76

CPC分类号： H01H13/85 ,  H01H2215/004 ,  H01H2219/056

摘要： A keypad apparatus for a portable communication device in which a plurality of pressurizing protrusions are integrated with a plurality of dome switches is provided. To this end, the keypad apparatus includes a keypad comprising a plurality of key buttons, a front frame provided on a top surface of the keypad, a light path provided on a bottom surface of the keypad, and a plurality of dome switches provided on a bottom surface of the light path, such that a respective plurality of pressurizing protrusions are integrated with the plurality of dome switches on top surfaces of the plurality of dome switches.

摘要翻译： 提供了一种便携式通信装置的键盘装置，其中多个加压突起与多个圆顶开关集成。 为此，键盘装置包括键盘，其包括多个键按钮，设置在键盘的顶面上的前框​​架，设置在键盘的底面上的光路以及设置在键盘上的多个圆顶开关 使得多个加压突起与多个圆顶开关的顶表面上的多个圆顶开关一体化。

公开(公告)号：US08772652B2

公开(公告)日：2014-07-08

申请号：US13117268

申请日：2011-05-27

申请人： Byung-Sun Kim ,  Min-Su Jung ,  Cheol-Hee Kim

发明人： Byung-Sun Kim ,  Min-Su Jung ,  Cheol-Hee Kim

IPC分类号： H01H9/26

CPC分类号： H01H13/705 ,  H01H2221/056 ,  H01H2223/036 ,  H01H2231/022 ,  H01H2233/03 ,  H04M1/23

摘要： A keypad assembly includes an operation member deformed according to user's manipulation to operate key switches, a binding member disposed on a top surface of the operation member, binding pieces extending and bent from the binding member to enclose sides of the operation member on an edge of the binding member, and a manipulation member disposed on a top surface of the binding member, the manipulation member including at least one key tops, in which the binding members are bound onto inner side walls of a housing of the portable terminal.

摘要翻译： 键盘组件包括根据用户的操纵而变形以操作键开关的操作构件，设置在操作构件的顶表面上的装订构件，从装订构件延伸和弯曲的绑定件，以将操作构件的侧面包围在操作构件的边缘上 装订构件和设置在装订构件的顶表面上的操纵构件，操纵构件包括至少一个键顶，其中装订构件被绑定到便携式终端的壳体的内侧壁上。

公开(公告)号：US08486827B2

公开(公告)日：2013-07-16

申请号：US13262293

申请日：2009-12-30

申请人： Se Hoon Yoo ,  Chang Woo Lee ,  Jun Ki Kim ,  Jeong Han Kim ,  Cheol Hee Kim ,  Young Ki Ko ,  Yue Seon Shin

发明人： Se Hoon Yoo ,  Chang Woo Lee ,  Jun Ki Kim ,  Jeong Han Kim ,  Cheol Hee Kim ,  Young Ki Ko ,  Yue Seon Shin

IPC分类号： H01L21/768

CPC分类号： H01L21/68785 ,  H01L21/68721 ,  H01L21/76898

摘要： A device of filling metal in a through-via-hole formed in a semiconductor wafer and a method of filling metal in a through-via-hole using the same are disclosed. A device of filling metal in a through-via-hole formed in a semiconductor wafer includes a jig base comprising a jig configured to fix the wafer having the through-via-hole formed therein; a upper chamber 120 installed on the jig base; a lower chamber installed under the jig base; a heater installed in the upper chamber, the heater configured to apply heat to filling metal placed on the wafer to melt the filling metal; and a vacuum pump configured to generate pressure difference between the upper chamber and the lower chamber by the pressure of the lower chamber reduced by discharging air of the lower chamber 130 outside, only to fill the melted filling metal in the through-via-hole.

摘要翻译： 公开了一种在半导体晶片中形成的通孔中填充金属的装置以及使用该通孔的贯通孔中填充金属的方法。 在半导体晶片中形成的通孔中填充金属的装置包括夹具基座，其包括夹具，其被配置为固定其中形成有通孔的晶片; 安装在夹具基座上的上腔室120; 安装在夹具底下的下腔室; 安装在所述上部腔室中的加热器，所述加热器构造成对放置在所述晶片上的填充金属施加热量以熔化所述填充金属; 以及真空泵，其构造成通过下部腔室130的空气排出而被下部腔室的压力产生上部腔室和下部腔室之间的压力差，仅将填充金属填充到通孔中。

公开(公告)号：US20120034776A1

公开(公告)日：2012-02-09

申请号：US13262293

申请日：2009-12-30

申请人： Se Hoon Yoo ,  Chang Woo Lee ,  Jun Ki Kim ,  Jeong Han Kim ,  Cheol Hee Kim ,  Young Ki Ko ,  Yue Seon Shin

发明人： Se Hoon Yoo ,  Chang Woo Lee ,  Jun Ki Kim ,  Jeong Han Kim ,  Cheol Hee Kim ,  Young Ki Ko ,  Yue Seon Shin

IPC分类号： H01L21/768 ,  B23K9/04

CPC分类号： H01L21/68785 ,  H01L21/68721 ,  H01L21/76898

摘要： A device of filling metal in a through-via-hole formed in a semiconductor wafer and a method of filling metal in a through-via-hole using the same are disclosed. A device of filling metal in a through-via-hole formed in a semiconductor wafer includes a jig base comprising a jig configured to fix the wafer having the through-via-hole formed therein; a upper chamber 120 installed on the jig base; a lower chamber installed under the jig base; a heater installed in the upper chamber, the heater configured to apply heat to filling metal placed on the wafer to melt the filling metal; and a vacuum pump configured to generate pressure difference between the upper chamber and the lower chamber by the pressure of the lower chamber reduced by discharging air of the lower chamber 130 outside, only to fill the melted filling metal in the through-via-hole.

摘要翻译： 公开了一种在半导体晶片中形成的通孔中填充金属的装置以及使用该通孔的贯通孔中填充金属的方法。 在半导体晶片中形成的通孔中填充金属的装置包括夹具基座，其包括夹具，其被配置为固定其中形成有通孔的晶片; 安装在夹具基座上的上腔室120; 安装在夹具底下的下腔室; 安装在所述上部腔室中的加热器，所述加热器构造成对放置在所述晶片上的填充金属施加热量以熔化所述填充金属; 以及真空泵，其构造成通过下部腔室130的空气排出而被下部腔室的压力产生上部腔室与下部腔室之间的压力差，仅将填充金属填充到通孔中。

公开(公告)号：US06658878B2

公开(公告)日：2003-12-09

申请号：US09933729

申请日：2001-08-22

申请人： Yong-Bo Shim ,  Hee-Soo Lee ,  Cheol-Hee Kim

发明人： Yong-Bo Shim ,  Hee-Soo Lee ,  Cheol-Hee Kim

IPC分类号： F25D1102

CPC分类号： F25D29/00 ,  F25B5/02 ,  F25B49/022 ,  F25B2600/2511 ,  F25D11/022 ,  F25D2400/04 ,  F25D2700/02 ,  F25D2700/12 ,  F25D2700/122

摘要： Disclosed herein is a multi-compartment type refrigerator and method for controlling the same. The refrigerator includes a plurality of storage compartments. A plurality of evaporators are each positioned in each of the storage compartments, respectively. A compressor supplies refrigerant to the evaporators through a branched refrigerant conduit. A plurality of opening/closing valves are each positioned on a refrigerant conduit upstream of each of the evaporators for selectively controlling supply of refrigerant to the evaporators. Reference compartment defining means defines as a reference storage compartment one of the storage compartments that has a relatively great load. Control means controls starting of the compressor depending on a change of a temperature of the reference storage compartment.

公开(公告)号：US08884172B2

公开(公告)日：2014-11-11

申请号：US13361168

申请日：2012-01-30

申请人： Soo-Hyun Lee ,  Seok-Gyu Lee ,  Cheol-Hee Kim

发明人： Soo-Hyun Lee ,  Seok-Gyu Lee ,  Cheol-Hee Kim

IPC分类号： H01H9/26 ,  H01H13/85

CPC分类号： H01H13/85 ,  H01H2215/004 ,  H01H2219/056

摘要： A keypad apparatus for a portable communication device in which a plurality of pressurizing protrusions are integrated with a plurality of dome switches is provided. To this end, the keypad apparatus includes a keypad comprising a plurality of key buttons, a front frame provided on a top surface of the keypad, a light path provided on a bottom surface of the keypad, and a plurality of dome switches provided on a bottom surface of the light path, such that a respective plurality of pressurizing protrusions are integrated with the plurality of dome switches on top surfaces of the plurality of dome switches.

摘要翻译： 提供了一种便携式通信装置的键盘装置，其中多个加压突起与多个圆顶开关集成。 为此，键盘装置包括键盘，其包括多个键按钮，设置在键盘的顶面上的前框​​架，设置在键盘的底面上的光路以及设置在键盘上的多个圆顶开关 使得多个加压突起与多个圆顶开关的顶表面上的多个圆顶开关一体化。

公开(公告)号：US08766114B2

公开(公告)日：2014-07-01

申请号：US13222040

申请日：2011-08-31

申请人： Soo-Hyun Lee ,  Seok-Gyu Lee ,  Cheol-Hee Kim

发明人： Soo-Hyun Lee ,  Seok-Gyu Lee ,  Cheol-Hee Kim

IPC分类号： H01H9/26 ,  H01H13/72 ,  H01H13/76

CPC分类号： H01H13/83 ,  G02B6/0043 ,  G02B6/006 ,  H01H2209/002 ,  H01H2209/082 ,  H01H2219/034 ,  H01H2219/056 ,  H01H2219/06 ,  H01H2219/062 ,  H01H2221/07

摘要： Provided is a keypad apparatus for a portable communication device structured to have a Printed Circuit Board (PCB) including a plurality of dome switches and a plurality of Light-Emitting Diodes (LEDs). The keypad apparatus includes a waveguide sheet portion provided on the dome switches, a plurality of printed surfaces which are printed on a top surface of the waveguide sheet portion and adjust a brightness of light from the LEDs, in a stepwise manner from a position distant from the LEDs to a position adjacent to the LEDs, and a keypad provided on the printed surfaces.

摘要翻译： 提供了一种用于便携式通信设备的键盘装置，其被构造为具有包括多个圆顶开关和多个发光二极管（LED）的印刷电路板（PCB）。 键盘装置包括设置在圆顶开关上的波导片部分，多个印刷表面，印刷在波导片部分的顶表面上，并从远离的位置以逐步的方式调节来自LED的光的亮度。 LED到与LED相邻的位置，以及设置在印刷表面上的键盘。

公开(公告)号：US08703732B2

公开(公告)日：2014-04-22

申请号：US13579256

申请日：2011-04-01

申请人： Nam-Soon Kim ,  In-Sung Song ,  Cheol-Hee Kim ,  Ga Hee Ha ,  Hyun-Taek Kim ,  So-Young Jeong ,  Jeong-Min Kim ,  Joo Heon Kim ,  Jin-Man Kim ,  Soo Young Jun

发明人： Nam-Soon Kim ,  In-Sung Song ,  Cheol-Hee Kim ,  Ga Hee Ha ,  Hyun-Taek Kim ,  So-Young Jeong ,  Jeong-Min Kim ,  Joo Heon Kim ,  Jin-Man Kim ,  Soo Young Jun

IPC分类号： C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K38/16 ,  A61K31/7105

摘要： The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway. Taken together, the present invention provide the strong evidence that the pharmaceutical composition, including inhibitors for TIP41 expression or activity can be used for cancer prevention and treatment as well as an anti-cancer adjuvant. Taken together, the pharmaceutical composition comprising inhibitors for expression or activity of TIP41 protein may be used for prevention and treatment of cancer or as an anti-cancer adjuvant.

摘要翻译： 本发明涉及包含用于预防和治疗癌症的TIP41蛋白表达或活性抑制剂的药物组合物。 当显示对TRAIL的抗性的肝癌细胞系用TIP41 siRNA和TRAIL处理时，在癌细胞中诱导细胞凋亡。 在具有抗TRAIL的肺癌和结肠癌的情况下也发现了相同的效果。 此外，在注射Huh7肝癌细胞的肿瘤异种移植物中证实了TIP41 siRNA和TRAIL的这种诱导凋亡，然后进行TIP41 siRNA转染和TRAIL处理。 此外，通过用TIP41 siRNA和TRAIL处理诱导肿瘤大小减少并诱导细胞凋亡的动物实验证实。 值得注意的是，MKK7 / JNK途径被证实可以介导应用TIP41 siRNA和TRAIL诱导的细胞凋亡。 验证细胞凋亡是由MKK7 / JNK信号通路的激活引起的。 综合起来，本发明提供了强有力的证据，包括用于TIP41表达或活性的抑制剂的药物组合物可用于癌症预防和治疗以及抗癌辅助剂。 总之，包含TIP41蛋白表达或活性抑制剂的药物组合物可用于预防和治疗癌症或作为抗癌辅助剂。