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1.发明授权Functionalized cyanine having a silane linker arm, a method of preparing thereof and uses thereof 失效具有硅烷连接臂的官能化花青，其制备方法及其应用公开(公告)号：US08624035B2
公开(公告)日：2014-01-07
申请号：US13125516
申请日：2009-10-21
申请人： Giuseppe Caputo , Ivana Miletto , Chiara Alessandra Bertolino , Gianmario Martra , Salvatore Coluccia
发明人： Giuseppe Caputo , Ivana Miletto , Chiara Alessandra Bertolino , Gianmario Martra , Salvatore Coluccia
CPC分类号： A61K49/0032 , C09B69/008 , G01N33/533
摘要： A silane-modified cyanine of Formula (I) includes the valence tautomers thereof: wherein R1 is a linear, saturated or unsaturated alkyl chain, having 1 to 30 carbon atoms, wherein one or more carbon atoms are optionally substituted by a 4-, 5- or 6-membered aromatic or non aromatic cyclic grouping of carbon atoms; R8 and R9 are independently selected from the group consisting of —OCH3, —OCH2CH3, —OCH2CH2CH3, —OCH(CH3)2, —OCH2CH2OCH3, —Cl, —Br, —I, Formula (II), Formula (III), —N(CH3)2, Formula (IV), Formula (V), methyl, ethyl, propyl, isopropyl. The synthesis method and the use as a fluorescent marker are for inorganic solid supports, for example silica nanoparticles, and/or for biomolecules such as peptides, antibodies, DNA, RNA, etc.
摘要翻译： 式（I）的硅烷改性花青包括其价态互变异构体：其中R1是具有1至30个碳原子的直链，饱和或不饱和的烷基链，其中一个或多个碳原子任选被4-，5 - 或6元芳族或非芳族环状基团; R 8和R 9独立地选自-OCH 3，-OCH 2 CH 3，-OCH 2 CH 2 CH 3，-OCH（CH 3）2，-OCH 2 CH 2 OCH 3，-Cl，-Br，-I，式（II），式（III） N（CH 3）2，式（IV），式（V），甲基，乙基，丙基，异丙基。 合成方法和荧光标记物的用途是用于无机固体载体，例如二氧化硅纳米颗粒，和/或用于生物分子如肽，抗体，DNA，RNA等。
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2.发明申请FUNCTIONALIZED CYANINE HAVING A SILANE LINKER ARM, A METHOD OF PREPARING THEREOF AND USES THEREOF 失效具有硅烷链接臂的官能化氰基，其制备方法及其用途公开(公告)号：US20110201784A1
公开(公告)日：2011-08-18
申请号：US13125516
申请日：2009-10-21
申请人： Giuseppe Caputo , Ivana Miletto , Chiara Alessandra Bertolino , Gianmario Martra , Salvatore Coluccia
发明人： Giuseppe Caputo , Ivana Miletto , Chiara Alessandra Bertolino , Gianmario Martra , Salvatore Coluccia
IPC分类号： C07K14/765 , C07F7/18 , C07K17/14
CPC分类号： A61K49/0032 , C09B69/008 , G01N33/533
摘要： A silane-modified cyanine of Formula (I) includes the valence tautomers thereof: wherein R1 is a linear, saturated or unsaturated alkyl chain, having 1 to 30 carbon atoms, wherein one or more carbon atoms are optionally substituted by a 4-, 5- or 6-membered aromatic or non aromatic cyclic grouping of carbon atoms; R8 and R9 are independently selected from the group consisting of —OCH3, —OCH2CH3, —OCH2CH2CH3, —OCH(CH3)2, —OCH2CH2OCH3, —Cl, —Br, —I, Formula (II), Formula (III), —N(CH3)2, Formula (IV), Formula (V), methyl, ethyl, propyl, isopropyl. The synthesis method and the use as a fluorescent marker are for inorganic solid supports, for example silica nanoparticles, and/or for biomolecules such as peptides, antibodies, DNA, RNA, etc.
摘要翻译： 式（I）的硅烷改性花青包括其价态互变异构体：其中R1是具有1至30个碳原子的直链，饱和或不饱和的烷基链，其中一个或多个碳原子任选被4-，5 - 或6元芳族或非芳族环状基团; R 8和R 9独立地选自-OCH 3，-OCH 2 CH 3，-OCH 2 CH 2 CH 3，-OCH（CH 3）2，-OCH 2 CH 2 OCH 3，-Cl，-Br，-I，式（II），式（III） N（CH 3）2，式（IV），式（V），甲基，乙基，丙基，异丙基。 合成方法和荧光标记物的用途是用于无机固体载体，例如二氧化硅纳米颗粒，和/或用于生物分子如肽，抗体，DNA，RNA等。
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