公开(公告)号：US20080293043A1

公开(公告)日：2008-11-27

申请号：US10554678

申请日：2003-11-04

申请人： Yoshihide Hayashizaki ,  Yasushi Okazaki ,  Chouhei Sakakura ,  Hisakazu Yamagishi Hisakazu

发明人： Yoshihide Hayashizaki ,  Yasushi Okazaki ,  Chouhei Sakakura ,  Hisakazu Yamagishi Hisakazu

IPC分类号： C12Q1/68 ,  C12Q1/32 ,  G01N33/574 ,  C07K16/00 ,  C12Q1/02

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N2333/90203 ,  G01N2333/988 ,  G01N2800/56

摘要： Metastatic cancer cells originating from gastric cancer are detected by a method comprising the step of collecting a biological sample from a subject, the step of detecting the presence of at least either aldehyde dehydrogenase or dopa decarboxylase in the biological sample of the subject, and the step of determining that the possibility of containing metastatic cancer cells originating from the gastric cancer in the sample is high when at least either aldehyde dehydrogenase or dopa decarboxylase is present. By the use of these as markers for metastatic cancer cells originating from gastric cancer, the presence or absence of peritoneal metastasis in a gastric cancer patient can be detected rapidly and reliably, and data important for deciding whether intraperitoneal cancer chemotherapy should be applied is provided.

摘要翻译： 通过包括从受试者收集生物样品的步骤的方法检测源自胃癌的转移性癌细胞，检测受试者的生物样品中至少一种醛脱氢酶或多巴脱羧酶的存在的步骤，以及步骤 确定当存在至少一种醛脱氢酶或多巴脱羧酶时，含有样品中源自胃癌的转移性癌细胞的可能性高。 通过使用这些作为来自胃癌的转移性癌细胞的标记物，可以快速可靠地检测胃癌患者腹膜转移的存在或不存在，并且提供了决定是否应用腹膜内癌化疗的重要数据。

公开(公告)号：US08017320B2

公开(公告)日：2011-09-13

申请号：US10554678

申请日：2008-05-14

申请人： Yoshihide Hayashizaki ,  Yasushi Okazaki ,  Chouhei Sakakura ,  Hisakazu Yamagishi Hisakazu

发明人： Yoshihide Hayashizaki ,  Yasushi Okazaki ,  Chouhei Sakakura ,  Hisakazu Yamagishi Hisakazu

IPC分类号： C12Q1/68

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N2333/90203 ,  G01N2333/988 ,  G01N2800/56

摘要： Metastatic cancer cells originating from gastric cancer are detected by a method comprising the step of collecting a biological sample from a subject, the step of detecting the presence of at least either aldehyde dehydrogenase or dopa decarboxylase in the biological sample of the subject, and the step of determining that the possibility of containing metastatic cancer cells originating from the gastric cancer in the sample is high when at least either aldehyde dehydrogenase or dopa decarboxylase is present. By the use of these as markers for metastatic cancer cells originating from gastric cancer, the presence or absence of peritoneal metastasis in a gastric cancer patient can be detected rapidly and reliably, and data important for deciding whether intraperitoneal cancer chemotherapy should be applied is provided.

摘要翻译： 通过包括从受试者收集生物样品的步骤的方法检测源自胃癌的转移性癌细胞，检测受试者的生物样品中至少一种醛脱氢酶或多巴脱羧酶的存在的步骤，以及步骤 确定当存在至少一种醛脱氢酶或多巴脱羧酶时，含有样品中源自胃癌的转移性癌细胞的可能性高。 通过使用这些作为来自胃癌的转移性癌细胞的标记物，可以快速可靠地检测胃癌患者腹膜转移的存在或不存在，并且提供了决定是否应用腹膜内癌化疗的重要数据。