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1.发明授权Malignant tumor cell suppressor protein, malignant tumor cell suppressor gene, maligant tumor cell suppressive viral vector, and kit using the same 有权恶性肿瘤细胞抑制蛋白，恶性肿瘤细胞抑制基因，恶性肿瘤细胞抑制病毒载体和使用其的试剂盒公开(公告)号：US08956606B2
公开(公告)日：2015-02-17
申请号：US11922933
申请日：2006-06-30
IPC分类号： C12N15/861 , C12N15/85 , C12N15/63 , C12N5/10
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00
摘要： A malignant tumor cell suppressor protein (a) or (b): (a) a protein comprising an amino acid sequence represented by SEQ ID No. 1; or (b) a protein comprising an amino acid sequence represented by SEQ ID No. 1, wherein one or more amino acid are deleted, substituted or added in the amino acid sequence set forth in SEQ ID No. 1.
摘要翻译： 恶性肿瘤细胞抑制蛋白（a）或（b）：（a）包含SEQ ID No.1所示的氨基酸序列的蛋白质; 或（b）包含SEQ ID No.1所示的氨基酸序列的蛋白质，其中一个或多个氨基酸被缺失，取代或加入到SEQ ID No.1所示的氨基酸序列中。
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公开(公告)号：US4072759A
公开(公告)日：1978-02-07
申请号：US740399
申请日：1976-11-10
申请人： Muneyoshi Ikezaki , Nobuo Ito , Yasushi Okazaki , Masao Hoshiyama , Taku Nagao , Hiromichi Nakajima
发明人： Muneyoshi Ikezaki , Nobuo Ito , Yasushi Okazaki , Masao Hoshiyama , Taku Nagao , Hiromichi Nakajima
IPC分类号： A61K31/135 , A61P9/04 , C07B61/00 , C07C67/00 , C07C213/00 , C07C217/60
CPC分类号： A61K31/135 , Y10S514/866
摘要： A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.
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3.发明授权公开(公告)号：US08017320B2
公开(公告)日：2011-09-13
申请号：US10554678
申请日：2008-05-14
IPC分类号： C12Q1/68
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/112 , G01N2333/90203 , G01N2333/988 , G01N2800/56
摘要： Metastatic cancer cells originating from gastric cancer are detected by a method comprising the step of collecting a biological sample from a subject, the step of detecting the presence of at least either aldehyde dehydrogenase or dopa decarboxylase in the biological sample of the subject, and the step of determining that the possibility of containing metastatic cancer cells originating from the gastric cancer in the sample is high when at least either aldehyde dehydrogenase or dopa decarboxylase is present. By the use of these as markers for metastatic cancer cells originating from gastric cancer, the presence or absence of peritoneal metastasis in a gastric cancer patient can be detected rapidly and reliably, and data important for deciding whether intraperitoneal cancer chemotherapy should be applied is provided.
摘要翻译： 通过包括从受试者收集生物样品的步骤的方法检测源自胃癌的转移性癌细胞，检测受试者的生物样品中至少一种醛脱氢酶或多巴脱羧酶的存在的步骤，以及步骤 确定当存在至少一种醛脱氢酶或多巴脱羧酶时，含有样品中源自胃癌的转移性癌细胞的可能性高。 通过使用这些作为来自胃癌的转移性癌细胞的标记物，可以快速可靠地检测胃癌患者腹膜转移的存在或不存在，并且提供了决定是否应用腹膜内癌化疗的重要数据。
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4.发明申请Malignant Tumor Cell Suppressor Protein, Malignant Tumor Cell Suppressor Gene, Maligant Tumor Cell Suppressive Viral Vector, and Kit Using the Same 有权恶性肿瘤细胞抑制蛋白，恶性肿瘤细胞抑制基因，恶性肿瘤细胞抑制性病毒载体和使用其的试剂盒公开(公告)号：US20100040578A1
公开(公告)日：2010-02-18
申请号：US11922933
申请日：2006-06-30
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00
摘要： A malignant tumor cell suppressor protein (a) or (b): (a) a protein comprising an amino acid sequence represented by SEQ ID No. 1; or (b) a protein comprising an amino acid sequence represented by SEQ ID No. 1, wherein one or more amino acid are deleted, substituted or added in the amino acid sequence set forth in SEQ ID No. 1.
摘要翻译： 恶性肿瘤细胞抑制蛋白（a）或（b）：（a）包含SEQ ID No.1所示的氨基酸序列的蛋白质; 或（b）包含SEQ ID No.1所示的氨基酸序列的蛋白质，其中一个或多个氨基酸被缺失，取代或加入到SEQ ID No.1所示的氨基酸序列中。
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5.发明授权Method of screening for agents that modulate Tysnd1 level or activity in a cell. 失效筛选调节细胞中Tysnd1水平或活性的试剂的方法。公开(公告)号：US07605005B2
公开(公告)日：2009-10-20
申请号：US12000158
申请日：2007-12-10
CPC分类号： A61K38/48 , C07K16/40 , G01N33/6893 , G01N2333/8139
摘要： The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 or PTS2 signals. Preferably, the polypeptide is encoded by Tysnd1.
摘要翻译： 本发明涉及一种用于治疗或诊断与细胞中过氧化物酶体生成相关的病症的药物组合物，其包含具有半胱氨酸蛋白酶活性并直接加工由PTS1或PTS2信号靶向的过氧化物酶的多肽。 优选地，多肽由Tysnd1编码。
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6.发明申请Pharmaceutical composition for treating and diagnosing a disorder associated with peroxisomal biogenesis and function 失效用于治疗和诊断与过氧化物酶体生物发生和功能相关的病症的药物组合物公开(公告)号：US20080160023A1
公开(公告)日：2008-07-03
申请号：US12000158
申请日：2007-12-10
IPC分类号： A61K39/395 , C12Q1/37 , A61P3/04 , A61P9/10
CPC分类号： A61K38/48 , C07K16/40 , G01N33/6893 , G01N2333/8139
摘要： The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 or PTS2 signals. Preferably, the polypeptide is encoded by Tysnd1.
摘要翻译： 本发明涉及一种用于治疗或诊断与细胞中过氧化物酶体生成相关的病症的药物组合物，其包含具有半胱氨酸蛋白酶活性并直接加工由PTS1或PTS2信号靶向的过氧化物酶的多肽。 优选地，多肽由Tysnd1编码。
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公开(公告)号：US4548186A
公开(公告)日：1985-10-22
申请号：US647824
申请日：1984-09-05
申请人： Katsuhiko Yamaji , Yasushi Nakata , Shigeyuki Kawai , Tatumi Hagihara , Koji Kageyama , Yasushi Okazaki
发明人： Katsuhiko Yamaji , Yasushi Nakata , Shigeyuki Kawai , Tatumi Hagihara , Koji Kageyama , Yasushi Okazaki
CPC分类号： F02N19/06 , F02M31/042 , Y02T10/126
摘要： The present invention provides an engine intake air preheating device having(A) an intake air preheater for preheating air to be fed into an engine, the preheater including a first metal hydride and being disposed within an intake air feeding tube for heat exchange with the intake air,(B) a hydrogen storage container including hydrogen or a second metal hydride, and(C) a pipe having a valve and connecting the intake air preheater to the hydrogen storage container so that hydrogen can move between them;and also an engine preheating device having(A') an engine preheater for preheating an engine, the preheater including a first metal hydride and being mounted on the engine for heat-exchange with the engine,(B) the hydrogen storage container, and(C) the pipe.There is also provided a method for preheating intake air at the time of starting the engine using an engine intake air preheating device such as the one according to the present invention.
摘要翻译： 本发明提供一种发动机进气预热装置，其具有（A）用于预热供给到发动机的空气的进气预热器，所述预热器包括第一金属氢化物，并设置在进气管内，与进气口进行热交换 空气，（B）包含氢或第二金属氢化物的储氢容器，（C）具有阀门并将进气预热器连接到储氢容器的管道，以使氢气在它们之间移动; 以及具有（A'）用于预热发动机的发动机预热器的发动机预热装置，所述预热器包括第一金属氢化物并且安装在所述发动机上用于与所述发动机进行热交换，（B）所述储氢容器和（ C）管道。 还提供了使用本发明的发动机进气预热装置，在起动发动机时预热进气的方法。
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公开(公告)号：US4032575A
公开(公告)日：1977-06-28
申请号：US618355
申请日：1975-10-01
申请人： Muneyoshi Ikezaki , Nobuo Ito , Yasushi Okazaki , Masao Hoshiyama , Taku Nagao , Hiromichi Nakajima
发明人： Muneyoshi Ikezaki , Nobuo Ito , Yasushi Okazaki , Masao Hoshiyama , Taku Nagao , Hiromichi Nakajima
IPC分类号： A61K31/135 , A61P9/04 , C07B61/00 , C07C67/00 , C07C213/00 , C07C217/60 , C07C91/22
CPC分类号： A61K31/135 , Y10S514/866
摘要： A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.
摘要翻译： 具有下式的化合物：其中环A为单羟基苯基或其药学上可接受的酸加成盐通过具有下式的化合物的催化氢化制备：其中A'为单苄氧基苯基，Y为 羰基或羟基亚甲基。 环A为4-羟基苯基或3-羟基苯基的化合物（I）可用作强心剂。 另一方面，环A为2-羟基苯基的化合物（I）可用作抗糖尿病药。
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9.发明授权.alpha.-(3,4-Dimethoxyphenethylaminomethyl)-3,4 or 3,5-dihydroxybenzylalcohols and salts thereof 失效{60-（3,4-二甲氧基苯乙氨基甲基）-3,4或3,5-二羟基苄醇及其盐
公开(公告)号：US3952021A
公开(公告)日：1976-04-20
申请号：US462594
申请日：1974-04-22
申请人： Muneyoshi Ikezaki , Yasushi Okazaki , Nobuo Ito , Taku Nagao , Masao Hoshiyama , Hiromichi Nakajima
发明人： Muneyoshi Ikezaki , Yasushi Okazaki , Nobuo Ito , Taku Nagao , Masao Hoshiyama , Hiromichi Nakajima
IPC分类号： A61K31/135 , A61K31/335 , A61K31/357 , A61P9/04 , C07C45/63 , C07C45/64 , C07C67/00 , C07C213/00 , C07C217/56 , C07C217/70 , C07D317/58 , C07C91/16 , C07D307/62
摘要： A compound of the formula: ##SPC1##Wherein Ring A' is dibenzyloxyphenyl and Y is carbonyl or hydroxymethylene, is subjected to catalytic hydrogenation. A compound of the formula: ##SPC2##Wherein Ring A is dihydroxyphenyl, is produced. The product is useful as a cardiotonic agent. It is also characterized by the high potency ratio of adrenergic .beta..sub.1 -receptor stimulating activity to adrenergic .beta..sub.2 -receptor stimulating activity.
摘要翻译： 下式的化合物：
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10.发明申请公开(公告)号：US20080293043A1
公开(公告)日：2008-11-27
申请号：US10554678
申请日：2003-11-04
IPC分类号： C12Q1/68 , C12Q1/32 , G01N33/574 , C07K16/00 , C12Q1/02
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/112 , G01N2333/90203 , G01N2333/988 , G01N2800/56
摘要： Metastatic cancer cells originating from gastric cancer are detected by a method comprising the step of collecting a biological sample from a subject, the step of detecting the presence of at least either aldehyde dehydrogenase or dopa decarboxylase in the biological sample of the subject, and the step of determining that the possibility of containing metastatic cancer cells originating from the gastric cancer in the sample is high when at least either aldehyde dehydrogenase or dopa decarboxylase is present. By the use of these as markers for metastatic cancer cells originating from gastric cancer, the presence or absence of peritoneal metastasis in a gastric cancer patient can be detected rapidly and reliably, and data important for deciding whether intraperitoneal cancer chemotherapy should be applied is provided.
摘要翻译： 通过包括从受试者收集生物样品的步骤的方法检测源自胃癌的转移性癌细胞，检测受试者的生物样品中至少一种醛脱氢酶或多巴脱羧酶的存在的步骤，以及步骤 确定当存在至少一种醛脱氢酶或多巴脱羧酶时，含有样品中源自胃癌的转移性癌细胞的可能性高。 通过使用这些作为来自胃癌的转移性癌细胞的标记物，可以快速可靠地检测胃癌患者腹膜转移的存在或不存在，并且提供了决定是否应用腹膜内癌化疗的重要数据。
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