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1.发明申请Use of conditional plasmodium strains lacking an essential gene in malaria vaccination 有权在疟疾疫苗接种中使用缺乏必需基因的条件疟原虫菌株公开(公告)号：US20100112010A1
公开(公告)日：2010-05-06
申请号：US12381326
申请日：2009-03-10
申请人： Choukri Ben Mamoun
发明人： Choukri Ben Mamoun
IPC分类号： A61K39/015 , A61K39/002
CPC分类号： A61K39/015 , A61K2039/5254 , Y02A50/412
摘要： The present invention relates to a malaria vaccine for administration to a host, comprising an attenuated malarial parasite with a gene that has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for continued in vivo survival and proliferation of the parasite and/or for infection of host red blood cells. The gene that has been rendered non-functional can be, e.g., a gene that encodes a nutrient transporter protein or a gene that encodes an enzyme involved in phospholipid biosynthesis. The invention also provides kits and methods that include such attenuated malarial parasites.
摘要翻译： 本发明涉及一种用于给宿主施用的疟疾疫苗，其包含具有已被赋予非功能性的基因的减毒的疟疾寄生虫，其中所述基因以天然形式存在时编码持续的体内存活所必需的蛋白质 和寄生虫的增殖和/或宿主红细胞的感染。 被赋予非功能性的基因可以是例如编码营养转运蛋白的基因或编码参与磷脂生物合成的酶的基因。 本发明还提供了包括这种减毒的疟疾寄生虫的试剂盒和方法。
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2.发明授权Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination 有权在疟疾疫苗接种中使用缺乏营养转运蛋白的条件疟原虫菌株公开(公告)号：US08128921B2
公开(公告)日：2012-03-06
申请号：US11827282
申请日：2007-07-11
CPC分类号： A61K39/015 , A61K2039/5254 , Y02A50/412
摘要： The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for continued in vivo survival and proliferation of the parasite and for infection of host red blood cells. The invention further relates to a malaria vaccine in which a gene that encodes a nutrient transporter protein has been rendered non-functional.
摘要翻译： 本发明涉及一种用于向宿主施用的疟疾疫苗，其包含具有非功能性基因的减毒疟疾寄生虫，其中当以天然存在形式存在时，该基因编码持续的体内存活所必需的蛋白质，以及 寄生虫的增殖和宿主红细胞的感染。 本发明还涉及一种疟疾疫苗，其中编码营养转运蛋白的基因已经变得不起作用。
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3.发明授权Use of conditional plasmodium strains lacking an essential gene in malaria vaccination 有权在疟疾疫苗接种中使用缺乏必需基因的条件疟原虫菌株公开(公告)号：US08153116B2
公开(公告)日：2012-04-10
申请号：US12381326
申请日：2009-03-10
申请人： Choukri Ben Mamoun
发明人： Choukri Ben Mamoun
CPC分类号： A61K39/015 , A61K2039/5254 , Y02A50/412
摘要： The present invention relates to a malaria vaccine for administration to a host, comprising an attenuated malarial parasite with a gene that has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for continued in vivo survival and proliferation of the parasite and/or for infection of host red blood cells. The gene that has been rendered non-functional can be, e.g., a gene that encodes a nutrient transporter protein or a gene that encodes an enzyme involved in phospholipid biosynthesis. The invention also provides kits and methods that include such attenuated malarial parasites.
摘要翻译： 本发明涉及一种用于给宿主施用的疟疾疫苗，其包含具有已被赋予非功能性的基因的减毒的疟疾寄生虫，其中所述基因以天然形式存在时编码持续的体内存活所必需的蛋白质 和寄生虫的增殖和/或宿主红细胞的感染。 被赋予非功能性的基因可以是例如编码营养转运蛋白的基因或编码参与磷脂生物合成的酶的基因。 本发明还提供了包括这种减毒的疟疾寄生虫的试剂盒和方法。
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