公开(公告)号：US09333173B2

公开(公告)日：2016-05-10

申请号：US13286788

申请日：2011-11-01

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61K9/14

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US20170049703A1

公开(公告)日：2017-02-23

申请号：US15143283

申请日：2016-04-29

申请人： Christian Barnett ,  Paul Ashton ,  Leigh T. Canham

发明人： Christian Barnett ,  Paul Ashton ,  Leigh T. Canham

IPC分类号： A61K9/14 ,  C07K16/22 ,  A61K39/395 ,  A61K9/00

CPC分类号： A61K9/146 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/143 ,  A61K9/145 ,  A61K9/19 ,  A61K9/5031 ,  A61K38/42 ,  A61K39/3955 ,  A61K39/39591 ,  C07K16/22 ,  C07K2317/24

摘要： The invention comprises a composition comprising a bioerodible porous silicon-based carrier material wherein the carrier material carries at least one large molecule therapeutic agent and at least one amorphous sugar, optionally further comprising a crystallization inhibitor. The composition may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The composition may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明包括一种包含生物可腐蚀多孔硅基载体材料的组合物，其中载体材料携带至少一种大分子治疗剂和至少一种无定形糖，任选地还包含结晶抑制剂。 组合物可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该组合物可用于治疗或预防患者如慢性疾病的病症。

公开(公告)号：US20160243276A1

公开(公告)日：2016-08-25

申请号：US15147203

申请日：2016-05-05

申请人： Paul ASHTON ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul ASHTON ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61L27/02 ,  A61K38/28 ,  A61L27/54 ,  A61K38/17 ,  C07K16/22 ,  A61L27/56 ,  A61K9/00 ,  A61K38/47

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US20120177695A1

公开(公告)日：2012-07-12

申请号：US13286788

申请日：2011-11-01

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K39/395 ,  A61K38/47 ,  A61P27/06 ,  A61K9/00 ,  A61P27/02 ,  A61K38/28 ,  A61K38/42

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US20170035690A1

公开(公告)日：2017-02-09

申请号：US15299050

申请日：2016-10-20

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61L27/54 ,  A61L27/56 ,  A61K39/395

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US11026885B2

公开(公告)日：2021-06-08

申请号：US15147203

申请日：2016-05-05

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K38/17 ,  A61K38/28 ,  A61K38/47 ,  A61L27/02 ,  A61L27/54 ,  A61L27/56 ,  C07K16/22 ,  A61K39/395

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.