公开(公告)号：US20170035690A1

公开(公告)日：2017-02-09

申请号：US15299050

申请日：2016-10-20

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61L27/54 ,  A61L27/56 ,  A61K39/395

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US09333173B2

公开(公告)日：2016-05-10

申请号：US13286788

申请日：2011-11-01

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61K9/14

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US20170049703A1

公开(公告)日：2017-02-23

申请号：US15143283

申请日：2016-04-29

申请人： Christian Barnett ,  Paul Ashton ,  Leigh T. Canham

发明人： Christian Barnett ,  Paul Ashton ,  Leigh T. Canham

IPC分类号： A61K9/14 ,  C07K16/22 ,  A61K39/395 ,  A61K9/00

CPC分类号： A61K9/146 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/143 ,  A61K9/145 ,  A61K9/19 ,  A61K9/5031 ,  A61K38/42 ,  A61K39/3955 ,  A61K39/39591 ,  C07K16/22 ,  C07K2317/24

摘要： The invention comprises a composition comprising a bioerodible porous silicon-based carrier material wherein the carrier material carries at least one large molecule therapeutic agent and at least one amorphous sugar, optionally further comprising a crystallization inhibitor. The composition may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The composition may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明包括一种包含生物可腐蚀多孔硅基载体材料的组合物，其中载体材料携带至少一种大分子治疗剂和至少一种无定形糖，任选地还包含结晶抑制剂。 组合物可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该组合物可用于治疗或预防患者如慢性疾病的病症。

公开(公告)号：US20160243276A1

公开(公告)日：2016-08-25

申请号：US15147203

申请日：2016-05-05

申请人： Paul ASHTON ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul ASHTON ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61L27/02 ,  A61K38/28 ,  A61L27/54 ,  A61K38/17 ,  C07K16/22 ,  A61L27/56 ,  A61K9/00 ,  A61K38/47

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US20120177695A1

公开(公告)日：2012-07-12

申请号：US13286788

申请日：2011-11-01

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K39/395 ,  A61K38/47 ,  A61P27/06 ,  A61K9/00 ,  A61P27/02 ,  A61K38/28 ,  A61K38/42

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/143 ,  A61K38/1709 ,  A61K38/28 ,  A61K38/47 ,  A61K39/3955 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  C07K16/22 ,  C12Y302/01017

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

摘要翻译： 本发明公开了以可控方式递送治疗剂，特别是大分子如蛋白质和抗体的生物腐蚀性装置。 该装置包括浸渍有治疗剂的多孔硅基载体材料。 该装置可以在体外或体内用于递送治疗剂，优选以预定的时间段（例如多天，数周或数月）以受控的方式递送。 该装置可用于治疗或预防患者的病症如慢性疾病。

公开(公告)号：US11026885B2

公开(公告)日：2021-06-08

申请号：US15147203

申请日：2016-05-05

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K38/17 ,  A61K38/28 ,  A61K38/47 ,  A61L27/02 ,  A61L27/54 ,  A61L27/56 ,  C07K16/22 ,  A61K39/395

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

公开(公告)号：US20160075776A1

公开(公告)日：2016-03-17

申请号：US14855946

申请日：2015-09-16

申请人： Paul Ashton ,  Hong Guo ,  Leigh T. Canham ,  Dinesh Nadarassan

发明人： Paul Ashton ,  Hong Guo ,  Leigh T. Canham ,  Dinesh Nadarassan

IPC分类号： C07K16/24 ,  A61K9/00 ,  C07K16/22 ,  A61K38/22 ,  A61K9/16 ,  C07K14/715

CPC分类号： A61K38/22 ,  A61K9/0051 ,  A61K47/02 ,  C07K14/7151 ,  C07K2319/30

摘要： This invention discloses reservoirs, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies. The reservoirs may comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The reservoir may be used in vitro or in vivo to maintain an equilibrium concentration of a therapeutic agent over an intended period of time such as over multiple days, weeks, months, or years. Additionally, the reservoir may be reloaded with additional therapeutic agent. These reservoirs may be used for treating or preventing conditions of a subject such as chronic diseases.

摘要翻译： 本发明公开了诸如用于递送治疗剂的植入物，特别是大分子如蛋白质和抗体的储库。 储存器可以包含浸渍有治疗剂的多孔硅基载体材料。 储存器可以在体外或体内使用以维持治疗剂在预期的时间段内的平衡浓度，例如超过几天，几周，几个月或几年。 此外，储存器可以用另外的治疗剂重新装载。 这些储存器可用于治疗或预防受试者例如慢性疾病的病症。

公开(公告)号：US20120134917A1

公开(公告)日：2012-05-31

申请号：US13359809

申请日：2012-01-27

申请人： Leigh T. Canham ,  Roger Aston

发明人： Leigh T. Canham ,  Roger Aston

IPC分类号： A61K51/00 ,  A61K8/02 ,  B32B5/16 ,  C01B33/02 ,  C01B33/113 ,  A61K8/25 ,  A61Q17/04

CPC分类号： A61Q19/00 ,  A61K8/25 ,  A61K33/00 ,  A61K2800/56 ,  A61Q17/04 ,  Y10S514/844 ,  Y10S514/951 ,  Y10T428/2982

摘要： Dermatological methods of cosmetic, therapeutic, prophylactic, and/or diagnostic treatment by topically applying compositions comprising a multiplicity of particles, at least one of the particles comprising porous and/or polycrystalline silicon. Included are methods and compositions for sun protection applications. The use of porous silicon, polycrystalline silicon, and porous silicon oxide mirrors is disclosed.

摘要翻译： 化妆品，治疗，预防和/或诊断治疗的皮肤病学方法是通过局部施用包含多个颗粒的组合物，至少一种颗粒包含多孔和/或多晶硅。 包括防晒应用的方法和组合物。 公开了使用多孔硅，多晶硅和多孔氧化硅镜。

公开(公告)号：US20110182967A1

公开(公告)日：2011-07-28

申请号：US13079791

申请日：2011-04-04

申请人： Leigh T. Canham ,  Christopher P. Barrett ,  Timothy I. Cox ,  Peter J. Wright ,  Andrew P. Bowditch

发明人： Leigh T. Canham ,  Christopher P. Barrett ,  Timothy I. Cox ,  Peter J. Wright ,  Andrew P. Bowditch

IPC分类号： A61F2/00 ,  B05D5/04

CPC分类号： A61K9/0087 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0097 ,  A61K31/00 ,  A61K31/01 ,  A61K31/7088 ,  A61K33/00 ,  A61K33/38 ,  A61K38/00 ,  A61K47/02 ,  A61L27/54 ,  A61L27/58 ,  A61M37/00 ,  A61K2300/00

摘要： A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In a second embodiment the implant may have a large number of holes which contain beneficial substance and which are closed by bio-errordable doors of different thickness so as to stagger the release of the beneficial substance over time as the doors are breached.

公开(公告)号：US20110052657A1

公开(公告)日：2011-03-03

申请号：US12805778

申请日：2010-08-19

申请人： Leigh T. Canham ,  Christopher P. Barrett ,  Timothy I. Cox ,  Peter J. Wright ,  Andrew P. Bowditch

发明人： Leigh T. Canham ,  Christopher P. Barrett ,  Timothy I. Cox ,  Peter J. Wright ,  Andrew P. Bowditch

IPC分类号： A61M31/00 ,  A61K38/02 ,  A61K31/7088 ,  A61K9/52

CPC分类号： A61K9/0087 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0097 ,  A61K31/00 ,  A61K31/01 ,  A61K31/7088 ,  A61K33/00 ,  A61K33/38 ,  A61K38/00 ,  A61K47/02 ,  A61L27/54 ,  A61L27/58 ,  A61M37/00 ,  A61K2300/00

摘要： A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In a second embodiment the implant may have a large number of holes which contain beneficial substance and which are closed by bio-errordable doors of different thickness so as to stagger the release of the beneficial substance over time as the doors are breached.

摘要翻译： 浸渍有益物质的多孔硅植入物，例如健康生理所需的微量矿物质，被皮下植入，并且在随后的几个月/年中完全被腐蚀以以受控的方式释放微量矿物质。 在第二实施例中，植入物可以具有大量的孔，其含有有益物质，并且由不同厚度的生物不可逆的门封闭，以便当门被破坏时随着时间的推移错开有益物质的释放。