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65 条记录 (耗时 0.027 秒)

    Compositions and Methods for Controlled Release of Agents
    6.
    发明申请
    Compositions and Methods for Controlled Release of Agents 审中-公开
    药剂控制释放的组成和方法

    公开(公告)号：US20160075776A1

    公开(公告)日：2016-03-17

    申请号：US14855946

    申请日：2015-09-16

    申请人： Paul Ashton ,  Hong Guo ,  Leigh T. Canham ,  Dinesh Nadarassan

    发明人： Paul Ashton ,  Hong Guo ,  Leigh T. Canham ,  Dinesh Nadarassan

    IPC分类号： C07K16/24 ,  A61K9/00 ,  C07K16/22 ,  A61K38/22 ,  A61K9/16 ,  C07K14/715

    CPC分类号： A61K38/22 ,  A61K9/0051 ,  A61K47/02 ,  C07K14/7151 ,  C07K2319/30

    摘要： This invention discloses reservoirs, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies. The reservoirs may comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The reservoir may be used in vitro or in vivo to maintain an equilibrium concentration of a therapeutic agent over an intended period of time such as over multiple days, weeks, months, or years. Additionally, the reservoir may be reloaded with additional therapeutic agent. These reservoirs may be used for treating or preventing conditions of a subject such as chronic diseases.

    摘要翻译： 本发明公开了诸如用于递送治疗剂的植入物，特别是大分子如蛋白质和抗体的储库。 储存器可以包含浸渍有治疗剂的多孔硅基载体材料。 储存器可以在体外或体内使用以维持治疗剂在预期的时间段内的平衡浓度，例如超过几天，几周，几个月或几年。 此外，储存器可以用另外的治疗剂重新装载。 这些储存器可用于治疗或预防受试者例如慢性疾病的病症。

    SUSTAINED RELEASE DRUG DELIVERY DEVICES, METHODS OF USE, AND METHODS OF MANUFACTURING THEREOF
    8.
    发明申请
    SUSTAINED RELEASE DRUG DELIVERY DEVICES, METHODS OF USE, AND METHODS OF MANUFACTURING THEREOF 有权
    持续释放药物递送装置，使用方法及其制造方法

    公开(公告)号：US20100119580A1

    公开(公告)日：2010-05-13

    申请号：US12689956

    申请日：2010-01-19

    申请人： Hong Guo ,  Paul Ashton

    发明人： Hong Guo ,  Paul Ashton

    IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K38/02 ,  A61K38/22 ,  A61K31/58 ,  A61K31/7064 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7072

    CPC分类号： A61K9/20 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/5089 ,  A61K31/58 ,  Y10T29/49888

    摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

    摘要翻译： 提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。 该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。 该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

    Sustained release of agents for localized pain management
    9.
    发明申请
    Sustained release of agents for localized pain management 审中-公开
    持续释放局部疼痛治疗药物

    公开(公告)号：US20080220062A1

    公开(公告)日：2008-09-11

    申请号：US11977148

    申请日：2007-10-23

    申请人： Paul Ashton

    发明人： Paul Ashton

    IPC分类号： A61K9/00 ,  A61P25/00

    CPC分类号： A61K9/0019 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0031 ,  A61K9/006

    摘要： The invention relates to the treatment of localized pain by providing sustained release of an agent suitable for treating pain, methods for preparing and administering the agent, and methods of formulating and administering the agent as a pharmaceutical preparation. The agent can be locally administered to reduce systemic concentrations of the agent.

    摘要翻译： 本发明涉及通过提供适于治疗疼痛的药剂的持续释放来治疗局部疼痛，制备和施用该药剂的方法，以及作为药物制剂的配制和施用方法。 可以局部施用该试剂以降低试剂的全身浓度。