公开(公告)号：US20120283956A1

公开(公告)日：2012-11-08

申请号：US13410950

申请日：2012-03-02

Applicant: Eytan RUPPIN ,  Tomer Shlomi ,  Ori Folger ,  Eyal Gottlieb ,  Christian Frezza

Inventor： Eytan RUPPIN ,  Tomer Shlomi ,  Ori Folger ,  Eyal Gottlieb ,  Christian Frezza

IPC: G06F19/26

CPC classification number: G16B5/00 ,  G06F17/11 ,  G16B20/00

Abstract: A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number.

Abstract translation: 通过选择在癌细胞中活跃的代谢反应来产生代谢反应代谢图的方法。 指定在癌细胞中发生的核心代谢反应。 对于每个排列，确定第k个非核心反应的抑制以及所有先前删除的非核心反应的抑制是否导致抑制任何核心反应或导致生物质代谢物对生物量的通量的抑制。 如果第k次非核心反应的抑制和所有先前删除的非核心反应的抑制不会导致任何核心反应的抑制，并且不会导致生物质代谢物的通量对生物量的抑制，则第k 非核心反应从一组非核心反应中删除。 确定不删除第k个非核心反应的排列数，然后基于该数量创建代谢图。