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    TIME-SERIES PHYLOGENETIC TUMOR EVOLUTION TREES
    1.
    发明申请
    TIME-SERIES PHYLOGENETIC TUMOR EVOLUTION TREES 审中-公开

    公开(公告)号：US20200004927A1

    公开(公告)日：2020-01-02

    申请号：US16022075

    申请日：2018-06-28

    申请人： International Business Machines Corporation

    发明人： Kahn Rhrissorrakrai ,  Filippo Utro ,  Chaya Levovitz ,  Laxmi Parida

    IPC分类号： G06F19/26 ,  G16H20/40

    摘要： A computer-implemented method incudes calculating, by a processor, based on sequence data for a tumor from a subject at a plurality of time points, a mutation frequency for each of a plurality of SSVs at each of the time points to provide a plurality of time-resolved mutation frequencies (between 0 and 1) for each of the plurality of SSVs, the sequence data including a plurality of simple somatic variations (SSVs) at each of the time points; binning, by the processor, the plurality of time-resolved mutation frequencies for each SSV at each of the time points to provide a matrix of SSVs and time points; converting, by the processor, the matrix cells to pseudo-clones; and constructing, by the processor, a time-series tumor evolution tree from the pseudo-clones, wherein each time point in the time-series evolution tree represents an event in the subject's cancer treatment.

    Techniques for controlling spatial structure of nucleic acid structures based on lattice-free, three dimensional junction coordinates
    2.
    发明授权
    Techniques for controlling spatial structure of nucleic acid structures based on lattice-free, three dimensional junction coordinates 有权

    公开(公告)号：US10289799B2

    公开(公告)日：2019-05-14

    申请号：US14874417

    申请日：2015-10-03

    申请人： Mark Bathe ,  Keyao Pan ,  Do-Nyun Kim

    发明人： Mark Bathe ,  Keyao Pan ,  Do-Nyun Kim

    IPC分类号： G01N33/48 ,  G06F15/00 ,  G06F19/16 ,  G06F19/26

    摘要： Techniques for controlling nucleic acid structures include determining, for each junction type, values for parameters indicating ground-state geometry and both translational and rotational stiffness coefficients. Topological design data indicates a number of bases in each helix connected to corresponding junctions. Initial positions of each base are determined by connecting helices to junctions using the ground-state geometry and arbitrary coordinates not confined to lattice coordinates. Misalignment vectors each indicate a difference in coordinates and orientations between initial positions of a pair of bases that are not adjacent in the initial positions but are adjacent or coincident in the design data. Forces and moments at the junctions to reduce misalignment magnitudes are determined based on the translational and rotational stiffness coefficients at each junction. Position and orientation in 3D coordinates of each base are determined by reducing or eliminating the misalignment magnitudes and balancing forces and moments across the nanostructure.

    Analysis system for analyzing biological samples, data processing method and computer program product
    3.
    发明授权
    Analysis system for analyzing biological samples, data processing method and computer program product 有权

    公开(公告)号：US10248373B2

    公开(公告)日：2019-04-02

    申请号：US15018006

    申请日：2016-02-08

    申请人： Roche Diagnostics Operations, Inc.

    发明人： Marco Maetzler ,  Juergen Wiemer

    IPC分类号： G06F3/14 ,  G06F19/26 ,  G06F19/28 ,  G06F3/0484

    摘要： Embodiments related to analysis system for analyzing biological samples, a data processing method and a computer program product are disclosed. An analyzer is coupled to an control computer and has a control application program which receives control data, sends analytical data, and generates a host screen image. A remote computer is coupled to the control computer, and provides a data manager application program which sends the control data to the control computer, receives the analytical data, and generates a first window. A remote application program interoperates with a host application program which generates a second window containing a duplicate of the host screen image. A user interface program displays a first display window and a second display window, the first display window being one of the first and second windows and the second display window containing a screen shot of the other one of the first and second windows.

    SMART TOILET
    5.
    发明申请
    SMART TOILET 审中-公开

    公开(公告)号：US20190062813A1

    公开(公告)日：2019-02-28

    申请号：US16107526

    申请日：2018-08-21

    申请人： Himanshu S. Amin

    发明人： Himanshu S. Amin

    IPC分类号： C12Q1/689 ,  E03D11/00 ,  G06F19/26 ,  G06F19/24 ,  B01L3/00

    摘要： Systems and methods disclosed herein relate to smart toilets (e.g. toilets with integrated stool analysis technology, urinalysis technology, deoxyribonucleic acid (DNA) sequencing technology, and/or logic circuitry which collectively enable the convenient, accessible, and real-time automation of waste analysis and microbiome screening). The smart toilet system can automatically perform various medical analyses on a user's biological waste, including DNA sequencing analyses, fecal occult blood tests, fecal pH tests, fecal fat tests, physical examinations of stool, particulate analyses of stool, physical analyses of urine, chemical analyses of urine, microscopic analyses of urine, particulate analyses of urine, and so on. The smart toilet system can then process and analyze the results in order to make appropriate diagnoses and/or to recommend various courses of action to the user so as to promote/preserve health.

    Method for Determining Heterologous Biosynthesis Pathways
    7.
    发明申请
    Method for Determining Heterologous Biosynthesis Pathways 审中-公开

    公开(公告)号：US20190018922A1

    公开(公告)日：2019-01-17

    申请号：US16067687

    申请日：2017-02-02

    申请人： King Abdullah University of Science and Technology

    发明人： Xin Gao ,  Hiroyuki Kuwahara ,  Meshari Saud Alazmi ,  Xuefeng Cui

    IPC分类号： G06F19/12 ,  G06F19/26

    摘要： The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.