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1.发明授权Nucleosides for suppressing or reducing the development of resistance in cytostatic therapy 有权用于抑制或减少细胞抑制治疗中抗性发展的核苷公开(公告)号：US08492537B2
公开(公告)日：2013-07-23
申请号：US12377239
申请日：2007-08-13
申请人： Rudolf Fahrig , Dieter Lohmann , Andreas Rolfs , Henrik Dieks , Janek Teubner , Jorg-Christian Heinrich
发明人： Rudolf Fahrig , Dieter Lohmann , Andreas Rolfs , Henrik Dieks , Janek Teubner , Jorg-Christian Heinrich
IPC分类号： C07H19/00 , C07H19/048
CPC分类号： C07D405/04
摘要： The invention relates to special nucleosides, for example, a nucleoside of the formula I, wherein R1-R5 are as described herein, and also to drugs which contain these nucleosides. Furthermore, the invention relates to the use of such nucleosides in a method for suppressing or reducing the formation of resistance in the case of cytotstatic treatment of a cancer patient.
摘要翻译： 本发明涉及特定的核苷，例如式I的核苷，其中R 1 -R 5如本文所述，还涉及含有这些核苷的药物。 此外，本发明涉及在癌症患者的细胞静脉内治疗的情况下抑制或减少抗性形成的方法中使用这种核苷。
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2.发明申请公开(公告)号：US20130172756A1
公开(公告)日：2013-07-04
申请号：US13342168
申请日：2012-01-02
CPC分类号： A61B8/4444 , A61B8/4461 , A61B8/4483 , G01S15/8915 , G01S15/8918 , G01S15/892 , G01S15/894 , G01S15/8979 , Y10T29/49954
摘要： Methods and systems for connection to a transducer in ultrasound probes are provided. One connection arrangement includes a connector having a transducer connection portion configured to couple to a transducer of an ultrasound probe and a scan head connection portion configured to extend from a scan head of the ultrasound probe containing the transducer. The transducer connection portion and the scan head connection portion being a single element.
摘要翻译： 提供了用于连接超声波探头中的换能器的方法和系统。 一种连接装置包括具有被配置为耦合到超声波探头的换能器的换能器连接部分和被配置为从包含换能器的超声波探头的扫描头延伸的扫描头连接部分的连接器。 换能器连接部分和扫描头连接部分是单个元件。
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3.发明申请公开(公告)号：US20130165794A1
公开(公告)日：2013-06-27
申请号：US13334294
申请日：2011-12-22
CPC分类号： H01R13/567 , A61B8/4411 , A61B8/4444 , A61B8/466 , A61B8/483 , A61B8/5246 , H01R13/58 , H01R2201/12 , Y10T29/49174
摘要： A connector assembly for coupling an coaxial cable to an ultrasound probe includes a cable clamp having an opening extending therethrough, the opening sized to receive a coaxial cable therethrough, the coaxial cable including a strain member and a plurality of coaxial cables extending therethrough, and a collet configured to couple to the cable clamp, the collet including an arbor that is configured to tension the strain member to a predetermined tension. A method of fabricating a connector assembly and an ultrasound imaging system are also described herein.
摘要翻译： 用于将同轴电缆耦合到超声波探头的连接器组件包括具有延伸穿过其中的开口的电缆夹，所述开口的尺寸设计成接收穿过其中的同轴电缆，所述同轴电缆包括应变构件和延伸穿过其中的多个同轴电缆， 套筒构造成联接到电缆夹，夹头包括心轴，其构造成将应变构件张紧到预定张力。 本文还描述了制造连接器组件和超声成像系统的方法。
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公开(公告)号：US20110297676A1
公开(公告)日：2011-12-08
申请号：US12997271
申请日：2009-06-10
CPC分类号： B65D77/04 , B65B9/20 , B65B29/028 , B65B2220/20 , B65D75/5827 , B65D85/8085 , B65D2313/10
摘要： For packaging foodstuffs or semi-luxury goods, the invention proposes packaging in which a protective packaging means (21) contains an inner packaging means (11) which contains the material to be packaged. The two packaging means are each produced from a strip (3, 13) by the strip being guided together to form a flexible tube (14). The inner packaging means is connected, in the region of its one end, to the outer packaging means such that, when the outer packaging means, which constitutes a protective packaging means, is torn open, the inner packaging means, rather than being destroyed, remains in the one part of the torn-open protective packaging means. The inner packaging means can preferably consist of a different material to the outer packaging means.
摘要翻译： 对于包装食品或半奢侈品，本发明提出一种包装，其中保护性包装装置（21）包含含有待包装材料的内包装装置（11）。 两个包装装置各自由条带（3,13）由条带一起被引导以形成柔性管（14）。 内部包装装置在其一端的区域中连接到外部包装装置，使得当构成保护性包装装置的外部包装装置被撕开时，内部包装装置而不是被破坏， 仍然是撕开保护性包装手段的一部分。 内包装装置可以优选地由与外包装装置不同的材料组成。
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5.发明申请公开(公告)号：US20090068286A1
公开(公告)日：2009-03-12
申请号：US11853540
申请日：2007-09-11
CPC分类号： A61K45/06 , A61K31/282 , A61K31/7068 , A61K31/7072 , A61K33/24 , A61K2300/00
摘要： The invention relates to methods of administration of at least one overexpression inhibitor of DNA repair genes and/or oncogenes (e.g., (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU), or a prodrug, or salt thereof) to increase the cytotoxic effect of a cytostatic or cytotoxic chemotherapeutic agent during and/or after chemotherapy, e.g., in the treatment of cancer.
摘要翻译： 本发明涉及至少一种DNA修复基因和/或癌基因的过表达抑制剂（例如（E）-5-（2-溴乙烯基）-2'-脱氧尿苷（BVDU）或前药或盐 ），以增加化疗期间和/或化疗后细胞抑制或细胞毒性化学治疗剂的细胞毒性作用，例如治疗癌症。
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6.发明申请Use of 5-substituterd nucleosides for reinforcing the apoptotic effect of cytostatic drugs 有权使用5-取代的核苷增强细胞生长抑制药物的凋亡作用公开(公告)号：US20060178338A1
公开(公告)日：2006-08-10
申请号：US10550013
申请日：2003-11-20
IPC分类号： A61K31/7072 , A61K31/7076
CPC分类号： A61K31/664 , A61K31/7072
摘要： The invention relates to the use of at least one overexpression inhibitor of DNA repair genes and oncogenes for producing a drug to increase the apoptotic effect of cytostatics after chemotherapy.
摘要翻译： 本发明涉及DNA修复基因和癌基因的至少一种过表达抑制剂用于制备药物以增加化疗后细胞凋亡的凋亡作用。
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公开(公告)号：US5036933A
公开(公告)日：1991-08-06
申请号：US415602
申请日：1989-10-02
申请人： Christian Heinrich
发明人： Christian Heinrich
IPC分类号： B62D6/02 , B62D6/00 , B62D7/14 , B62D7/15 , B62D113/00
CPC分类号： B62D7/1563
摘要： In normal operation, a control or regulating device controls vehicle rear wheel steering in accordance with freely-selectable specifications. If a malfunction of the control or regulating device is detected, the latter becomes inoperative immediately. A piston-cylinder unit drivingly connected to the front wheel steering and a piston-cylinder unit drivingly connected to the rear wheel steering are simultaneously positively coupled to one another, with the result that the rear wheel steering is actuated positively via the front wheel steering.
摘要翻译： 在正常操作中，控制或调节装置根据可自由选择的规格控制车辆后轮转向。 如果检测到控制或调节装置的故障，则后者立即失效。 驱动地连接到前轮转向件的活塞缸单元和驱动地连接到后轮转向件的活塞缸单元同时被积极地联接，结果是通过前轮转向主动地驱动后轮转向。
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9.发明授权Use of 5-substituted nucleosides for reinforcing the apoptotic effect of cytostatic drugs 有权使用5-取代的核苷增强细胞生长抑制药物的凋亡作用公开(公告)号：US07713948B2
公开(公告)日：2010-05-11
申请号：US10550013
申请日：2003-11-20
IPC分类号： A61K31/7072 , A61K31/70
CPC分类号： A61K31/664 , A61K31/7072
摘要： The invention relates to the use of at least one overexpression inhibitor of DNA repair genes and oncogenes for producing a drug to increase the apoptotic effect of cytostatics after chemotherapy.
摘要翻译： 本发明涉及DNA修复基因和癌基因的至少一种过表达抑制剂用于制备药物以增加化疗后细胞凋亡的凋亡作用。
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10.发明授权Process for automatic control of one or more devices by voice commands or by real-time voice dialog and apparatus for carrying out this process 有权用于通过语音命令或通过实时语音对话和用于执行该过程的装置自动控制一个或多个设备的过程公开(公告)号：US06839670B1
公开(公告)日：2005-01-04
申请号：US09043134
申请日：1996-09-09
申请人： Walter Stammler , Fritz Class , Carsten-Uwe M{hacek over (o)}ller , Gerhard Nüssle , Frank Reh , Burkard Buschkühl , Christian Heinrich
发明人： Walter Stammler , Fritz Class , Carsten-Uwe M{hacek over (o)}ller , Gerhard Nüssle , Frank Reh , Burkard Buschkühl , Christian Heinrich
IPC分类号： B60R16/02 , G10L15/00 , G10L15/04 , G10L15/06 , G10L15/10 , G10L15/14 , G10L15/18 , G10L15/183 , G10L15/20 , G10L15/26 , G10L15/28 , G10L21/02
CPC分类号： G10L15/063 , G10L15/142 , G10L15/183 , G10L15/26
摘要： A speech dialog system wherein a process for automatic control of devices by speech dialog is used applying methods of speech input, speech signal processing and speech recognition, syntatical-grammatical postediting as well as dialog, executive sequencing and interface control, and which is characterized in that syntax and command structures are set during real-time dialog operation; preprocessing, recognition and dialog control are designed for operation in a noise-encumbered environment; no user training is required for recognition of general commands; training of individual users is necessary for recognition of special commands; the input of commands is done in linked form, the number of words used to form a command for speech input being variable; a real-time processing and execution of the speech dialog is established; and the speech input and output is done in the hands-free mode.
摘要翻译： 一种语音对话系统，其中使用通过语音对话自动控制设备的过程，应用语音输入，语音信号处理和语音识别，语法语法贴图以及对话，执行排序和接口控制的方法，其特征在于 在实时对话操作期间设置语法和命令结构; 预处理，识别和对话控制设计用于在噪声环境中操作; 无需用户培训来识别一般命令; 个人用户的培训对于识别特殊命令是必要的; 命令的输入是以链接形式完成的，用于形成语音输入命令的单词数量是可变的; 建立语音对话的实时处理和执行; 并且语音输入和输出在免提模式下完成。
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