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    MICRORNA INHIBITORS COMPRISING LOCKED NUCLEOTIDES
    1.
    发明申请
    MICRORNA INHIBITORS COMPRISING LOCKED NUCLEOTIDES 失效
    包含锁定核苷酸的微阵列抑制剂

    公开(公告)号：US20120184596A1

    公开(公告)日：2012-07-19

    申请号：US13327507

    申请日：2011-12-15

    申请人： Christina Dalby ,  William S. Marshall ,  Eva van Rooij ,  Rusty Montgomery

    发明人： Christina Dalby ,  William S. Marshall ,  Eva van Rooij ,  Rusty Montgomery

    IPC分类号： A61K31/712 ,  A61P9/00 ,  C12N5/071 ,  A61P9/04 ,  C07H21/04 ,  C12N15/113 ,  C07H21/00 ,  A61P9/10

    CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/346 ,  C12Q2600/178

    摘要： The invention provides chemically modified oligonucleotides capable of inhibiting the expression (e.g., abundance) of miR-208 family miRNAs, including miR-208a, miR-208b, and/or miR-499. The invention provides in some embodiments, oligonucleotides capable of inhibiting, in a specific fashion, the expression or abundance of each of miR-208a, miR-208b, and miR-499. The invention further provides pharmaceutical compositions comprising the oligonucleotides, and methods of treating patients having conditions or disorders relating to or involving a miR-208 family miRNA, such as a cardiovascular condition. In various embodiments, the oligonucleotides provide advantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability.

    摘要翻译： 本发明提供能够抑制miR-208家族miRNA（包括miR-208a，miR-208b和/或miR-499）的表达（例如丰度）的化学修饰的寡核苷酸。 本发明在一些实施方案中提供能够以特定方式抑制miR-208a，miR-208b和miR-499中每一种的表达或丰度的寡核苷酸。 本发明进一步提供了包含寡核苷酸的药物组合物，以及治疗与miR-208家族miRNA相关或涉及miR-208家族miRNA例如心血管病症的病症或病症的患者的方法。 在各种实施方案中，寡核苷酸提供效力，递送效率，靶特异性，毒性和/或稳定性中的一种或多种的优点。

    MicroRNA inhibitors comprising locked nucleotides
    5.
    发明授权
    MicroRNA inhibitors comprising locked nucleotides 失效
    包含锁定核苷酸的微小RNA抑制剂

    公开(公告)号：US08642751B2

    公开(公告)日：2014-02-04

    申请号：US13327507

    申请日：2011-12-15

    申请人： Christina Dalby ,  William S. Marshall ,  Eva van Rooij ,  Rusty Montgomery

    发明人： Christina Dalby ,  William S. Marshall ,  Eva van Rooij ,  Rusty Montgomery

    IPC分类号： C07H21/04

    CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/346 ,  C12Q2600/178

    摘要： The invention provides chemically modified oligonucleotides capable of inhibiting the expression (e.g., abundance) of miR-208 family miRNAs, including miR-208a, miR-208b, and/or miR-499. The invention provides in some embodiments, oligonucleotides capable of inhibiting, in a specific fashion, the expression or abundance of each of miR-208a, miR-208b, and miR-499. The invention further provides pharmaceutical compositions comprising the oligonucleotides, and methods of treating patients having conditions or disorders relating to or involving a miR-208 family miRNA, such as a cardiovascular condition. In various embodiments, the oligonucleotides provide advantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability.

    摘要翻译： 本发明提供能够抑制miR-208家族miRNA（包括miR-208a，miR-208b和/或miR-499）的表达（例如丰度）的化学修饰的寡核苷酸。 本发明在一些实施方案中提供能够以特定方式抑制miR-208a，miR-208b和miR-499中每一种的表达或丰度的寡核苷酸。 本发明进一步提供了包含寡核苷酸的药物组合物，以及治疗与miR-208家族miRNA相关或涉及miR-208家族miRNA例如心血管病症的病症或病症的患者的方法。 在各种实施方案中，寡核苷酸提供效力，递送效率，靶特异性，毒性和/或稳定性中的一种或多种的优点。