公开(公告)号：US06255087B1

公开(公告)日：2001-07-03

申请号：US09331404

申请日：1999-06-21

申请人： Christoph Dingler ,  Nicholas John Holman

发明人： Christoph Dingler ,  Nicholas John Holman

IPC分类号： C12P1716

CPC分类号： C12P17/182

摘要： A process for preparing enantiomerically pure alcohols of the formula I (Ia or Ib) where the substituents have the following meanings: R1 hydrogen or substituted or unsubstituted C1-C6-alkyl, C1-C6-alkoxy or C1-C6-alkanoyl, R2 and R3 independently of one another hydrogen or substituted or unsubstituted C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkanoyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl or C1-C6-alkylsulfonyl, R4 substituted or unsubstituted C1-C6-alkyl, C3-C8-cycloalkyl, which comprises reducing compounds of the formula II where the substituents R1 to R4 have the abovementioned meanings  in aqueous solution in the presence of a carbon source and of a microorganism or of a reducing agent, of a cofactor and of an enzyme, to compounds of the formula I.

摘要翻译： 制备式I（Ia或Ib）的对映异构体纯的醇的方法，其中取代基具有以下含义：R 1氢或取代或未取代的C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基或C 1 -C 6 - 烷酰基，R 2和R 3独立地 的一个或多个取代或未取代的C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷酰基，C 1 -C 6 - 烷硫基，C 1 -C 6烷基亚磺酰基或C 1 -C 6烷基磺酰基， - 烷基，C 3 -C 8 - 环烷基，其包括在辅助因子的碳源和微生物或还原剂存在下的水溶液中取代基R 1至R 4具有上述含义的式II的还原性化合物 和酶，与式I化合物反应。