公开(公告)号：US09678075B2

公开(公告)日：2017-06-13

申请号：US14124580

申请日：2012-06-08

申请人： Christoph Schröder ,  Harish Srinivasan ,  Jörg Hoheisel ,  François Radvanyi

发明人： Christoph Schröder ,  Harish Srinivasan ,  Jörg Hoheisel ,  François Radvanyi

IPC分类号： G01N33/574

CPC分类号： G01N33/57407 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

摘要： The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.

公开(公告)号：US20140193927A1

公开(公告)日：2014-07-10

申请号：US14124580

申请日：2012-06-08

申请人： Christoph Schröder ,  Harish Srinivasan ,  Jörg Hiheisel ,  François Radvanyi

发明人： Christoph Schröder ,  Harish Srinivasan ,  Jörg Hiheisel ,  François Radvanyi

IPC分类号： G01N33/574

CPC分类号： G01N33/57407 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

摘要： The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.

摘要翻译： 本发明涉及癌症预测领域。 具体地说，本发明涉及一种用于预测膀胱癌治疗后受试者膀胱癌复发风险的方法，包括以下步骤：确定选自表中所示生物标志物的至少一种生物标志物的量，并比较所述 至少一种具有所述至少一种生物标志物的参考量的生物标志物，由此预测膀胱癌复发的风险。 本发明还考虑了用于鉴定需要进一步膀胱癌治疗的受试者的方法。 此外，还包括用于执行所述方法的诊断装置和试剂盒。

公开(公告)号：US20110281077A1

公开(公告)日：2011-11-17

申请号：US12777724

申请日：2010-05-11

申请人： Dario Pisignano ,  Adriana Lucia Angela Biasco ,  Andrea Camposeo ,  Stefano Pagliara ,  Alessandro Polini ,  Heinz-Christoph Schröder ,  Werner E.G. Müller

发明人： Dario Pisignano ,  Adriana Lucia Angela Biasco ,  Andrea Camposeo ,  Stefano Pagliara ,  Alessandro Polini ,  Heinz-Christoph Schröder ,  Werner E.G. Müller

IPC分类号： B32B3/30 ,  C12P7/00

CPC分类号： C12P3/00 ,  C12Y304/22 ,  Y10T428/2457

摘要： The present invention concerns a process for preparing products having layers/films of silicon derivates comprising the following steps: a) Preparing a mould made of elastomeric material and having a plurality of grooves with mutual spacing in the range from 1 μm to 1 mm; b) incubating the mould of step a) in a solution of silicateins in a range of temperatures from 2 to 10° C. and in a range of time from a few minutes to 103 hours; c) providing a target substrate of silicon or oxides thereof; d) transferring the silicateins from the mould to the said target substrate through soft lithography technique for a time period from a few seconds to 103 hours and removing the elastomeric mould; e) incubating the substrate with patterned silicateins of step d) in a solution of one or more precursors belonging to the class of silane compounds for a time period in a range from a few seconds to 103 hours in a temperature range from 2° C. to 25° C. The invention concerns also a product obtainable by the disclosed process having remarkable electrical features.

摘要翻译： 本发明涉及一种制备具有硅衍生物层/膜的产品的方法，包括以下步骤：a）制备由弹性体材料制成的模具，并具有多个相互间隔在1μm至1mm范围内的槽; b）将步骤a）的模具在2至10℃的温度范围内和在几分钟至103小时的时间范围内的硅酸盐溶液中孵育; c）提供硅或其氧化物的目标衬底; d）通过软光刻技术将硅酸盐从模具转移到所述目标衬底上，持续时间为几秒至103小时，并移除弹性模具; e）在2℃的温度范围内将属于一类硅烷化合物的一种或多种前体的步骤d）的图案化硅酸盐的底物与几秒钟至103小时的时间段相混合。 本发明还涉及通过所公开的具有显着电气特征的方法可获得的产品。

公开(公告)号：US09551035B2

公开(公告)日：2017-01-24

申请号：US13576912

申请日：2011-02-15

申请人： Christoph Schröder ,  Jörg Hoheisel ,  Tatjana Crnogorac-Jurcevic

发明人： Christoph Schröder ,  Jörg Hoheisel ,  Tatjana Crnogorac-Jurcevic

IPC分类号： G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5302

摘要： The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.

摘要翻译： 本发明涉及癌症诊断领域。 具体地，本发明涉及一种用于诊断受试者中胰腺癌的方法，包括以下步骤：在怀疑患有胰腺癌的受试者样品中测定选自表1所示的生物标志物的至少一种生物标志物的量，并比较所述 至少一种具有参考的生物标志物的量，由此诊断胰腺癌。 本发明还考虑了用于鉴定受试者是否需要胰腺癌疗法的方法，其包括以下步骤：上述方法和如果要诊断为所述受试者被诊断为需要胰腺癌治疗的受试者的另一步骤 患有胰腺癌。 此外，还考虑用于执行所述方法的诊断装置和套件。

公开(公告)号：US20130045884A1

公开(公告)日：2013-02-21

申请号：US13576912

申请日：2011-02-15

申请人： Christoph Schröder ,  Jörg Hoheisel ,  Tatjana Crnogorac-Jurcevic

发明人： Christoph Schröder ,  Jörg Hoheisel ,  Tatjana Crnogorac-Jurcevic

IPC分类号： C40B30/04 ,  C40B40/10 ,  G01N33/574

CPC分类号： G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5302

摘要： The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.

摘要翻译： 本发明涉及癌症诊断领域。 具体地，本发明涉及一种用于诊断受试者中胰腺癌的方法，包括以下步骤：在怀疑患有胰腺癌的受试者样品中测定选自表1所示的生物标志物的至少一种生物标志物的量，并比较所述 至少一种具有参考的生物标志物的量，由此诊断胰腺癌。 本发明还考虑了用于鉴定受试者是否需要胰腺癌疗法的方法，其包括以下步骤：上述方法和如果要诊断为所述受试者被诊断为需要胰腺癌治疗的受试者的另一步骤 患有胰腺癌。 此外，还考虑用于执行所述方法的诊断装置和套件。