-
公开(公告)号：US5643867A
公开(公告)日：1997-07-01
申请号：US413920
申请日：1995-03-29
CPC分类号： A61K38/30
摘要： This is a method for treating catabolic conditions in individuals by administering a composition containing a complex of insulin-like growth factor (IGF) and insulin-like growth factor binding protein-3 (IGFBP-3).
摘要翻译： 这是通过施用含有胰岛素样生长因子（IGF）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的复合物的组合物来治疗个体中的分解代谢病症的方法。
-
2.发明授权
公开(公告)号：US5723441A
公开(公告)日：1998-03-03
申请号：US521907
申请日：1995-08-31
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61K38/28 , A61K38/30 , A61P3/08 , A61P13/02 , A61P13/12 , A61P15/00 , C07K14/435 , C07K14/475 , C12P21/00 , A61K38/27
CPC分类号： A61K38/30 , A61K38/1709
摘要： Treatment with IGF/IGFBP-3 complex increases renal tubular mass and potentiates and/or stimulates kidney function in subjects suffering from acute and chronic renal failure or insufficiency resulting from such disorders as glomerulonephritis, glomerulosclerosis, interstitial nephritis, acute tubular necrosis due to ischemia and drug-induced toxicity, diabetic and autoimmune nephropathies and renal dysfunction due to acute and chronic rejection episodes in post-transplantation patients.
摘要翻译： 用IGF / IGFBP-3复合物治疗增加肾小管质量，并且增强和/或刺激受试者患有急性和慢性肾衰竭或由诸如肾小球性肾炎，肾小球硬化，间质性肾炎，由于局部缺血导致的急性肾小管坏死等疾病引起的功能不全 药物诱导的毒性，糖尿病和自身免疫性肾病以及移植后患者急性和慢性排斥反应引起的肾功能不全。
-
3.发明授权Treatment of immunologic and hematologic disorders with IGFBP alone or complexed with IGF 失效用IGFBP单独或与IGF复合治疗免疫学和血液学疾病
公开(公告)号：US5527776A
公开(公告)日：1996-06-18
申请号：US393249
申请日：1995-02-23
IPC分类号： A61K38/28 , A61K38/00 , A61K38/17 , A61K38/30 , A61P1/00 , A61P17/00 , A61P27/16 , A61P31/04 , A61P35/02 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/475 , C07K2/00 , A61K38/27 , C07K14/00
CPC分类号： A61K38/30 , A61K38/1709
摘要： This invention includes a method of treating subjects with immunologic and hematologic disorders, such as immune deficiencies and anemias characterized by deficient total hemoglobin. The treatment includes administering to the subject insulin-like growth factor binding protein-3 (IGFBP-3), alone or in a complex including an insulin-like growth factor (IGF), in an amount sufficient to improve the immunologic and/or hematologic disorder, for example, increasing the level of total hemoglobin or improving immune deficiencies, such as occur post-chemotherapy. Another aspect of the invention includes administering IGFBP-3 alone to treat IGF-driven lymphoproliferative conditions, such as leukemias, inflammatory skin diseases, and nasal polyps.
摘要翻译： 本发明包括用免疫学和血液学疾病治疗受试者的方法，例如以总血红蛋白不足为特征的免疫缺陷和贫血。 该治疗包括以足以改善免疫和/或血液学的量的单独或包含胰岛素样生长因子（IGF）的复合物对受试者胰岛素样生长因子结合蛋白-3（IGFBP-3）施用 例如，增加总血红蛋白的水平或改善免疫缺陷，例如化疗后发生。 本发明的另一方面包括单独施用IGFBP-3以治疗IGF驱动的淋巴增殖性病症，例如白血病，炎性皮肤病和鼻息肉。
-
公开(公告)号：US5407913A
公开(公告)日：1995-04-18
申请号：US984936
申请日：1992-12-03
CPC分类号： A61K38/30
摘要： This is a method for enhancing systemic tissue repair in patients with burns, trauma and peptic ulcers, as well as patients about to undergo, is undergoing or just having undergone surgery. The method comprises systemically administering to such individuals a therapeutic composition comprising IGF and IGFBP. The preferred form is IGF-I/IGFBP-3.
摘要翻译： 这是一种用于增强烧伤，创伤和消化性溃疡患者的全身组织修复的方法，以及即将进行或正在进行手术的患者。 所述方法包括向所述个体全身施用包含IGF和IGFBP的治疗组合物。 优选的形式是IGF-I / IGFBP-3。
-
-
-
搜索结果
4 条记录 (耗时 0.015 秒)
