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公开(公告)号：US09068282B2
公开(公告)日：2015-06-30
申请号：US12934666
申请日：2009-04-08
摘要： A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
摘要翻译： 用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。 至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。 所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。 控制器引起支撑结构和至少一个施加器之间的相对运动，并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。 生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。 通过适当选择材料加工，卷绕策略和后卷绕处理，可以控制生物材料装置的性能。
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公开(公告)号：US20110076384A1
公开(公告)日：2011-03-31
申请号：US12934666
申请日：2009-04-08
摘要： A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
摘要翻译： 用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。 至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。 所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。 控制器引起支撑结构和至少一个施加器之间的相对运动，并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。 生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。 通过适当选择材料加工，卷绕策略和后卷绕处理，可以控制生物材料装置的性能。
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公开(公告)号：US20070128087A1
公开(公告)日：2007-06-07
申请号：US10569114
申请日：2004-08-13
摘要： The invention relates to a device for automated bioreactor sampling connected to a reactor comprising a sampler, at least one tube fluidly connecting said reactor with said sampler and a pump for pumping fluids from said reactor to said sampler and vice versa. Particularly simple and essentially dead volume-free sampling can be achieved by providing means for flushing at least parts of the tube with gas/sterile air between individual sampling steps. The invention furthermore relates to a method of operation of such a device.
摘要翻译： 本发明涉及一种用于自动生物反应器取样的装置，其连接到包括采样器的反应器，至少一个管子将所述反应器与所述采样器流体连接，并且泵将流体从所述反应器泵送到所述采样器，反之亦然。 可以通过提供在每个采样步骤之间用气体/无菌空气冲洗管的至少部分的装置来实现特别简单且基本上无死体积的取样。 本发明还涉及这种装置的操作方法。
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