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1.发明申请Apparatus for precisely adjusting the position of workstations in a document printer/copier 审中-公开用于精确调整文件打印机/复印机中工作站位置的装置公开(公告)号：US20070059070A1
公开(公告)日：2007-03-15
申请号：US11591334
申请日：2006-11-01
申请人： Donald Hensel , Christopher Garcia , D. Kepner , Gary Nichols , Jeffrey Ulreich , Thomas Albrecht , Donald Buch , Charles Spehrley
发明人： Donald Hensel , Christopher Garcia , D. Kepner , Gary Nichols , Jeffrey Ulreich , Thomas Albrecht , Donald Buch , Charles Spehrley
IPC分类号： G03G15/00
CPC分类号： G03G21/1647 , G03G2221/1606 , G03G2221/1654
摘要： Apparatus for precisely positioning one or more of the workstations of a document printer/copier relative to an internal drum, including a first member, attached to either a workstation or the internal drum, having two sections, each section having a reference surface forming an angle therebetween, an actuator for changing the included angle between the first reference surface and second reference surface, thus enabling the included angle to be increased or decreased, and a second member having a reference surface that mates with the pair of reference surfaces, associated with the other of the workstation or the internal drum, so as to accurately adjust the workstation relative to the internal drum dependent upon the included angle of the first reference surface and second reference surface.
摘要翻译： 用于相对于内鼓精确定位文件打印机/复印机的一个或多个工作站的装置，包括附接到工作站或内鼓的第一构件，具有两个部分，每个部分具有形成角度的参考表面 其间具有用于改变第一参考表面和第二参考表面之间的夹角的致动器，从而能够增加或减小夹角，并且具有与所述一对参考表面配合的参考表面的第二构件与第二参考表面相关联 工作站或内鼓中的另一个，以便根据第一参考表面和第二参考表面的夹角，相对于内鼓来精确地调整工作站。
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公开(公告)号：US09428567B2
公开(公告)日：2016-08-30
申请号：US13997503
申请日：2011-12-22
申请人： Kenan Christopher Garcia , Aron Levin , Aaron Ring
发明人： Kenan Christopher Garcia , Aron Levin , Aaron Ring
摘要： Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins can be used in pharmaceutical compositions for use in treatment of cancer and in stimulating the immune response.
摘要翻译： 提供了新的人白介素-2（IL-2）突变蛋白或其变体，以及核酸分子及其变体。 还公开了产生这些突变蛋白的方法以及刺激动物的免疫系统的方法。 此外，本发明提供了包含本发明的核酸分子的重组表达载体和已经引入了表达载体的宿主细胞。 包括药物组合物，其包括治疗有效量的本发明的人IL-2突变蛋白和药学上可接受的载体。 IL-2突变蛋白可用于用于治疗癌症和刺激免疫应答的药物组合物中。
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3.发明申请INDUCIBLE SELF-CLEAVING PROTEASE TAG AND METHOD OF PURIFYING RECOMBINANT PROTEINS USING THE SAME 审中-公开可诱导的自我清除蛋白质标签和使用其来纯化重组蛋白的方法公开(公告)号：US20130012687A1
公开(公告)日：2013-01-10
申请号：US13261221
申请日：2010-09-21
CPC分类号： C12P21/06 , C07K1/22 , C07K2319/50
摘要： A method of purifying a protein is disclosed which entails: a) fusing a site-specific affinity-tagged cysteine protease domain to a target protein to form a tagged fusion protein; b) activating the site-specific cysteine protease domain of the tagged fusion protein by subjecting the site-specific affinity-tagged cysteine protease domain to an inducer, which induces autoprocessing at a cleavage site; thereby releasing untagged target protein; and c) isolating the untagged target protein.
摘要翻译： 公开了一种纯化蛋白质的方法，其需要：a）将位点特异性亲和标记的半胱氨酸蛋白酶结构域融合到靶蛋白以形成标记的融合蛋白; b）通过使位点特异性亲和标记的半胱氨酸蛋白酶结构域诱导诱导物来激活标记的融合蛋白的位点特异性半胱氨酸蛋白酶结构域，诱导物诱导在切割位点的自动加工; 从而释放未标记的靶蛋白; 和c）分离未标记的靶蛋白。
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4.发明申请SUPERKINES AND SYNTHEKINES: REPURPOSED CYTOKINES WITH NEW AND ENHANCED SIGNALING ACTIVITIES 有权监督和合作：用新的和增强的信号活动修复细胞因子公开(公告)号：US20160244499A1
公开(公告)日：2016-08-25
申请号：US14419873
申请日：2013-08-08
IPC分类号： C07K14/54
CPC分类号： C07K14/5406 , A61K38/00 , C07K14/52
摘要： Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (IL-4) muteins. The disclosed methods encompass administering an IL-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population.
摘要翻译： 本文公开了具有增强的对IL-4细胞因子受体的选择性的生物活性增强的IL-4细胞因子组合物及其使用方法。 这些组合物包括白细胞介素-4（IL-4）突变蛋白。 所公开的方法包括施用IL-4以治疗肿瘤疾病，自身免疫性疾病，感染性疾病或扩大造血细胞群体。
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公开(公告)号：US20140105855A1
公开(公告)日：2014-04-17
申请号：US14009904
申请日：2012-04-06
IPC分类号： C07K14/54
CPC分类号： C07K14/54 , A61K38/00 , C07H21/00 , C07K2319/00 , C07K2319/21
摘要： IL-17 Receptor binding proteins, including non-naturally occurring and recombinantly modified proteins, methods of making and using such molecules as therapeutic, prophylactic and diagnostic agents are provided.
摘要翻译： 提供IL-17受体结合蛋白，包括非天然存在和重组修饰的蛋白质，制备和使用这些分子的治疗剂，预防剂和诊断剂的方法。
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公开(公告)号：US20120269765A1
公开(公告)日：2012-10-25
申请号：US13386652
申请日：2010-07-26
IPC分类号： A61K38/20 , C07K19/00 , C12N15/24 , C12N15/62 , C07K16/24 , A61K39/395 , A61P29/00 , A61P17/06 , A61P19/02 , A61P1/04 , A61P25/00 , C12P21/02 , C12N5/071 , C12N5/10 , C07K14/54
CPC分类号： C07K14/5434 , C07K2319/30
摘要： Polypeptides, including non-naturally occurring and recombinantly modified polypeptides related to the p19 subunit of IL-23, methods of making such molecules and methods of using such molecules as therapeutic, prophylactic and diagnostic agents are provided.
摘要翻译： 提供了多肽，包括与IL-23的p19亚基相关的非天然存在和重组修饰的多肽，制备这种分子的方法以及使用这些分子作为治疗剂，预防和诊断剂的方法。
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公开(公告)号：US20060106476A1
公开(公告)日：2006-05-18
申请号：US11243354
申请日：2005-10-04
IPC分类号： G06F19/00
CPC分类号： G05B19/4067 , B65G2207/14 , G05B19/4097 , G05B19/41805 , G05B2219/35223 , G05B2219/35228 , Y02P90/04 , Y02P90/265
摘要： Automatic generation of a tolerance scheme includes accessing data defining a three-dimensional model that defines a part for manufacture, identifying a tolerance feature in the three-dimensional model, determining at least one unconstrained degree of control for the tolerance feature, automatically creating a tolerance scheme for the tolerance feature, and rendering the tolerance scheme and the three-dimensional model in a window such that the tolerance scheme annotates the tolerance feature. The tolerance scheme is based on an engineering standard for communicating a tolerance and constrains the unconstrained degree of control.
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8.发明申请Apparatus for precisely adjusting the position of work stations in a document printer/copier 有权用于精确调整文件打印机/复印机中工作位置的装置公开(公告)号：US20050058478A1
公开(公告)日：2005-03-17
申请号：US10925394
申请日：2004-08-25
申请人： Donald Hensel , Christopher Garcia , D. Kepner , Gary Nichols , Jeffrey Ulreich , Thomas Albrecht , Donald Buch , Charles Spehrley
发明人： Donald Hensel , Christopher Garcia , D. Kepner , Gary Nichols , Jeffrey Ulreich , Thomas Albrecht , Donald Buch , Charles Spehrley
CPC分类号： G03G21/1647 , G03G2221/1606 , G03G2221/1654
摘要： Apparatus for precisely positioning one or more of the work stations of a document printer/copier relative to an internal drum, including a first member, attached to either a work station or the internal drum, having two sections, each section having a reference surface forming an angle therebetween, an actuator for changing the included angle between the first reference surface and second reference surface, thus enabling the included angle to be increased or decreased, and a second member having a reference surface that mates with the pair of reference surfaces, associated with the other of the work station or the internal drum, so as to accurately adjust the work station relative to the internal drum dependent upon the included angle of the first reference surface and second reference surface.
摘要翻译： 用于相对于内鼓精确定位文件打印机/复印机的一个或多个工作站的装置，包括附接到工作站或内部鼓的第一构件，具有两个部分，每个部分具有参考表面成形 用于改变第一参考表面和第二参考表面之间的夹角的致动器，从而能够增加或减小夹角，并且具有与该对参考表面配合的基准表面的第二构件相关联 与工作站或内部鼓中的另一个相关联，以便根据第一参考表面和第二参考表面的夹角来相对于内鼓来精确地调整工作站。
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公开(公告)号：US20130064788A1
公开(公告)日：2013-03-14
申请号：US13501244
申请日：2010-10-11
申请人： Thomas M. Barnes , Michael M. Schmidt , Bracken M. King , K. Christopher Garcia , Sashank Reddy , Gregory James Sieczkiewicz , Lauren K. Ely
发明人： Thomas M. Barnes , Michael M. Schmidt , Bracken M. King , K. Christopher Garcia , Sashank Reddy , Gregory James Sieczkiewicz , Lauren K. Ely
IPC分类号： A61K38/20 , C12P21/02 , C12N5/10 , C12N1/21 , A61P29/00 , C12N1/19 , C07K14/54 , C07K16/24 , C07H21/04 , A61P37/02 , A61K39/395 , C12N1/15
CPC分类号： C07K14/54 , C07K14/7155
摘要： Binding proteins, including non-naturally occurring and recombinantly modified proteins that bind to an IL-17R and including proteins having a mutated IL-17 cytokine sequence, methods of making such molecules and methods of using such molecules as therapeutic, prophylactic and diagnostic agents are provided.
摘要翻译： 结合蛋白质，包括结合IL-17R的非天然存在和重组修饰的蛋白质，并且包括具有突变的IL-17细胞因子序列的蛋白质，制备这种分子的方法和使用这些分子作为治疗剂，预防剂和诊断剂的方法是 提供。
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公开(公告)号：US20140046026A1
公开(公告)日：2014-02-13
申请号：US13997503
申请日：2011-12-22
申请人： Kenan Christopher Garcia , Aron Levin , Aaron Ring
发明人： Kenan Christopher Garcia , Aron Levin , Aaron Ring
IPC分类号： C07K14/55
摘要： Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins can be used in pharmaceutical compositions for use in treatment of cancer and in stimulating the immune response.
摘要翻译： 提供了新的人白介素-2（IL-2）突变蛋白或其变体，以及核酸分子及其变体。 还公开了产生这些突变蛋白的方法以及刺激动物的免疫系统的方法。 此外，本发明提供了包含本发明的核酸分子的重组表达载体和已经引入了表达载体的宿主细胞。 包括药物组合物，其包括治疗有效量的本发明的人IL-2突变蛋白和药学上可接受的载体。 IL-2突变蛋白可用于用于治疗癌症和刺激免疫应答的药物组合物中。
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