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1.发明申请GLYCINE TRANSPORTER-1 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF 有权甘氨酸转运蛋白-1抑制剂，其制备方法及其用途公开(公告)号：US20110312931A1
公开(公告)日：2011-12-22
申请号：US13151992
申请日：2011-06-02
申请人： Christopher L. CIOFFI , Mark A. WOLF , Peter R. GUZZO , Shuang LIU , Kashinath SADALAPURE , Visweswaran PARTHASARATHY , Jun-Ho MAENG
发明人： Christopher L. CIOFFI , Mark A. WOLF , Peter R. GUZZO , Shuang LIU , Kashinath SADALAPURE , Visweswaran PARTHASARATHY , Jun-Ho MAENG
IPC分类号： A61K31/496 , C07D403/12 , C07D401/04 , C07D405/04 , C07D405/14 , C07D401/12 , C07D487/08 , A61K31/495 , A61K31/454 , A61K31/4995 , A61P25/18 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24 , A61P3/10 , A61P3/04 , A61P3/00 , A61P25/04 , A61P25/30 , A61P25/34 , A61P25/08 , A61P25/14 , A61P25/06 , A61P27/02 , C07D295/26
CPC分类号： C07D295/26 , C07D205/04 , C07D207/48 , C07D211/58 , C07D213/71 , C07D233/84 , C07D241/04 , C07D249/04 , C07D309/14 , C07D313/04 , C07D405/12 , C07D487/08
摘要： The compounds of the present invention are represented by the following formula (I): wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.
摘要翻译： 本发明的化合物由下式（I）表示：其中取代基R 1，R 2，R 3，R 4，（R 5）m，R 6，A，X和Y如本文所定义。 该化合物可用于治疗由抑制GlyT-1产生或依赖于其的依赖性疾病的方法。
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2.发明授权Glycine transporter-1 inhibitors, methods of making them, and uses thereof 有权甘氨酸转运蛋白-1抑制剂，其制备方法及其应用公开(公告)号：US09045445B2
公开(公告)日：2015-06-02
申请号：US13151992
申请日：2011-06-02
IPC分类号： A61K31/496 , C07D403/12 , C07D295/26 , C07D205/04 , C07D207/48 , C07D211/58 , C07D213/71 , C07D233/84 , C07D241/04 , C07D249/04 , C07D309/14 , C07D313/04 , C07D405/12 , C07D487/08
CPC分类号： C07D295/26 , C07D205/04 , C07D207/48 , C07D211/58 , C07D213/71 , C07D233/84 , C07D241/04 , C07D249/04 , C07D309/14 , C07D313/04 , C07D405/12 , C07D487/08
摘要： The compounds of the present invention are represented by the following formula (I): wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.
摘要翻译： 本发明的化合物由下式（I）表示：其中取代基R 1，R 2，R 3，R 4，（R 5）m，R 6，A，X和Y如本文所定义。 该化合物可用于治疗由抑制GlyT-1产生或依赖于其的依赖性疾病的方法。
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