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1.发明授权公开(公告)号：US07101676B2
公开(公告)日：2006-09-05
申请号：US10339217
申请日：2003-01-09
IPC分类号： G01N33/53
CPC分类号： C07K14/005 , C12N2740/16222 , G01N33/56988 , G01N2500/02
摘要： The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labeled HIV-1 psi-site oligonucleotide and an amount of the molecule to be tested under binding conditions; and determining the amount of oligonucleotide bound to the NCp7 polypeptide, wherein a decrease in the amount of oligonucleotide bound in the presence of the molecule compared with the amount of oligonucleotide bound in the absence of the molecule indicates that the molecule inhibits binding of NCp7 polypeptide to the oligonucleotide.
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公开(公告)号：US06583108B1
公开(公告)日：2003-06-24
申请号：US09144428
申请日：1998-08-31
申请人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
发明人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
IPC分类号： A61K3857
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114
摘要： The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.
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公开(公告)号：US07452859B2
公开(公告)日：2008-11-18
申请号：US11390775
申请日：2006-03-27
申请人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
发明人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114
摘要： The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.
摘要翻译： 本发明提供了蛋白质，多肽，核酸序列，构建体，表达载体，宿主细胞，药物组合物和使用人胎盘比肯宁，丝氨酸蛋白酶抑制剂结构域及其片段的方法。
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公开(公告)号：US07019123B2
公开(公告)日：2006-03-28
申请号：US09974026
申请日：2001-10-10
申请人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
发明人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
IPC分类号： C07H21/04
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114
摘要： The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof
摘要翻译： 本发明提供蛋白质，多肽，核酸序列，构建体，表达载体，宿主细胞，药物组合物和使用人胎盘bikunin，丝氨酸蛋白酶抑制物结构域及其片段的方法
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