公开(公告)号：US20110157592A1

公开(公告)日：2011-06-30

申请号：US12980094

申请日：2010-12-28

Applicant: Jia-Huey Tsao ,  Jau-Jiu Ju ,  Hsueh-Ching Shih ,  Chun-Min Su ,  Hung-Yueh Chen ,  Kuo-Chi Chiu ,  Chih-Cheng Feng ,  Sheng-Li Chang ,  Hsing-Cheng Yu

Inventor： Jia-Huey Tsao ,  Jau-Jiu Ju ,  Hsueh-Ching Shih ,  Chun-Min Su ,  Hung-Yueh Chen ,  Kuo-Chi Chiu ,  Chih-Cheng Feng ,  Sheng-Li Chang ,  Hsing-Cheng Yu

IPC: G01N21/55 ,  G01N1/10

CPC classification number: G01N21/553

Abstract: The present invention provides a surface plasmon resonance (SPR) unit having at least one microfluidic channel with grating structures embedded in so that a grating-coupled surface plasmon resonance can be induced by an incident light while fluid in the microfluidic channel contacts or flows through the grating area. The induced variation of optical signal due to the SPR effect is analyzed for performing bio-screening and assay of bioaffinity reaction. Meanwhile, present invention further provides an SPR inspection system possessing a rotation power to the SPR unit such that the SPR unit is capable of rotating and thereby generating a centrifugal force for driving the flow inside the microfluidic channels so as to achieve the label-free and high throughput SPR inspection system with low-cost.

Abstract translation: 本发明提供一种表面等离子体共振（SPR）单元，其具有至少一个具有嵌入光栅结构的微流体通道，从而可以通过入射光诱导光栅耦合的表面等离子体共振，同时微流体通道中的流体接触或流过 光栅区域。 分析由于SPR效应引起的光信号变化，进行生物亲和反应的生物筛选和测定。 同时，本发明还提供了一种具有向SPR单元的旋转动力的SPR检查系统，使得SPR单元能够旋转，从而产生用于驱动微流体通道内的流动的离心力，从而实现无标签和 高吞吐量SPR检测系统，成本低廉。

公开(公告)号：US07377183B2

公开(公告)日：2008-05-27

申请号：US11525577

申请日：2006-09-22

Applicant: Chun-min Su ,  Han-sheng Chuang ,  Yi-Lin Ho

Inventor： Chun-min Su ,  Han-sheng Chuang ,  Yi-Lin Ho

IPC: G01F1/58

CPC classification number: A61M5/16886 ,  G01F1/56 ,  G01F1/708 ,  G01F1/74

Abstract: A device for measuring a flow of a fluid is provided. The device includes a base, a channel, and at least two electronic circuits. The channel is mounted on the base, flowing the fluid therein and having at least two sections, and the at least two electronic circuits are electrically connected to the respective at least two sections, detecting a respective variation signal corresponding to the respective at least two sections so as to obtain the flow according to the respective variation signal.

Abstract translation: 提供了一种用于测量流体流动的装置。 该装置包括基座，通道和至少两个电子电路。 通道安装在基座上，使流体流动并具有至少两个部分，并且至少两个电子电路电连接到相应的至少两个部分，检测对应于相应的至少两个部分的相应变化信号 以便根据各个变化信号获得流量。

公开(公告)号：US20120307248A1

公开(公告)日：2012-12-06

申请号：US13304697

申请日：2011-11-28

Applicant: Hsueh-Ching Shih ,  Kun-Chih Tsai ,  Chih-Cheng Feng ,  Jia-Huey Tsao ,  Chun-Min Su

Inventor： Hsueh-Ching Shih ,  Kun-Chih Tsai ,  Chih-Cheng Feng ,  Jia-Huey Tsao ,  Chun-Min Su

IPC: G01N21/55 ,  G01N27/447

CPC classification number: G01N21/553 ,  G01N21/07 ,  G01N21/648

Abstract: A liquid transporting device using electrowetting on dielectric technique is provided. A sampling liquid is accurately transported on a substrate in a channel-free manner. The sampling liquid is spun off the substrate by a centrifugal force after the sampling liquid has been detected. The liquid transporting device can be applied to a biochemical detecting apparatus and a biochemical detecting method, thereby fulfilling requirements of accurate sample transportation in the biomedical field. The liquid transporting device is simplified to reduce overall costs, thus being helpful for decreasing high prices of biomedical detecting systems.

Abstract translation: 提供了使用电润湿介质技术的液体输送装置。 采样液体以无通道的方式在衬底上精确地传送。 检测出取样液后，采用离心力将取样液从基板上剥离出来。 液体输送装置可应用于生物化学检测装置和生物化学检测方法，从而满足生物医学领域精确样品运输的要求。 液体输送装置被简化以降低整体成本，从而有助于降低生物医学检测系统的高价格。

公开(公告)号：US08189183B2

公开(公告)日：2012-05-29

申请号：US12580619

申请日：2009-10-16

Applicant: Hsueh-Ching Shih ,  Jia-Huey Tsao ,  Chih-Cheng Feng ,  Chun-Lin Chiang ,  Chun-Min Su ,  Kuo-Chi Chiu

Inventor： Hsueh-Ching Shih ,  Jia-Huey Tsao ,  Chih-Cheng Feng ,  Chun-Lin Chiang ,  Chun-Min Su ,  Kuo-Chi Chiu

IPC: G01N21/01 ,  G01N21/55 ,  G01M19/00

CPC classification number: G01N21/553 ,  G01N21/01

Abstract: An optical inspection apparatus capable of adjusting an incident angle of a detected light beam and adjusting a detecting angle for detecting the detected light beam. A driving mechanism is used to actuate two arms having a light source and a detector disposed thereon respectively to conduct a relative movement between the two arms so as to control the incident angle and the detecting angle. By means of the embodiments, mechanism for adjusting the angle is simplified so that the apparatus is capable of being adapted to combine with the application of micro sensors such that practicality of modularization design and microminiaturization and convenience of operation are capable of being greatly improved and that the cost can be reduced.

Abstract translation: 一种光学检查装置，其能够调整检测光束的入射角度并调整检测角度以检测检测到的光束。 驱动机构用于致动具有光源的两个臂和分别布置在其上的检测器，以在两个臂之间进行相对移动，以便控制入射角和检测角度。 通过这些实施例，简化了用于调节角度的机构，使得该装置能够适应于微型传感器的应用，使得模块化设计和微型化以及操作方便性的实用性能够大大提高，并且 可以降低成本。

公开(公告)号：US20100253947A1

公开(公告)日：2010-10-07

申请号：US12580619

申请日：2009-10-16

Applicant: HSUEH-CHING SHIH ,  JIA-HUEY TSAO ,  CHIH-CHENG FENG ,  CHUN-LIN CHIANG ,  CHUN-MIN SU ,  KUO-CHI CHU

Inventor： HSUEH-CHING SHIH ,  JIA-HUEY TSAO ,  CHIH-CHENG FENG ,  CHUN-LIN CHIANG ,  CHUN-MIN SU ,  KUO-CHI CHU

IPC: G01N21/01 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/01

Abstract: An optical inspection apparatus capable of adjusting an incident angle of a detected light beam and adjusting a detecting angle for detecting the detected light beam. A driving mechanism is used to actuate two arms having a light source and a detector disposed thereon respectively to conduct a relative movement between the two arms so as to control the incident angle and the detecting angle. By means of the embodiments, mechanism for adjusting the angle is simplified so that the apparatus is capable of being adapted to combine with the application of micro sensors such that practicality of modularization design and microminiaturization and convenience of operation are capable of being greatly improved and that the cost can be reduced.

Abstract translation: 一种光学检查装置，其能够调整检测光束的入射角度并调整检测角度以检测检测到的光束。 驱动机构用于致动具有光源的两个臂和分别布置在其上的检测器，以在两个臂之间进行相对移动，以便控制入射角和检测角度。 通过这些实施例，简化了用于调节角度的机构，使得该装置能够适应于微型传感器的应用，使得模块化设计和微型化以及操作方便性的实用性能够大大提高，并且 可以降低成本。

公开(公告)号：US20070119261A1

公开(公告)日：2007-05-31

申请号：US11525577

申请日：2006-09-22

Applicant: Chun-min Su ,  Han-sheng Chuang ,  Yi-lin Ho

Inventor： Chun-min Su ,  Han-sheng Chuang ,  Yi-lin Ho

IPC: G01F1/58

CPC classification number: A61M5/16886 ,  G01F1/56 ,  G01F1/708 ,  G01F1/74

Abstract: A device for measuring a flow of a fluid is provided. The device includes a base, a channel, and at least two electronic circuits. The channel is mounted on the base, flowing the fluid therein and having at least two sections, and the at least two electronic circuits are electrically connected to the respective at least two sections, detecting a respective variation signal corresponding to the respective at least two sections so as to obtain the flow according to the respective variation signal.

Abstract translation: 提供了一种用于测量流体流动的装置。 该装置包括基座，通道和至少两个电子电路。 通道安装在基座上，使流体流动并具有至少两个部分，并且至少两个电子电路电连接到相应的至少两个部分，检测对应于相应的至少两个部分的相应变化信号 以便根据各个变化信号获得流量。