利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

62 条记录 (耗时 0.025 秒)

    PULMONARY PHARMACEUTICAL FORMULATIONS
    1.
    发明申请
    PULMONARY PHARMACEUTICAL FORMULATIONS 有权

    公开(公告)号：US20220296612A1

    公开(公告)日：2022-09-22

    申请号：US17519119

    申请日：2021-11-04

    申请人： Civitas Therapeutics, Inc.

    发明人： Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel LeBlanc ,  Mark A. Tracy ,  Rebecca Martin

    IPC分类号： A61K31/58 ,  A61K9/00 ,  A61K9/16 ,  A61K45/06 ,  A61K31/13 ,  A61K47/36 ,  A61K38/29

    摘要： The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.

    Low Dose Pharmaceutical Powders for Inhalation
    6.
    发明申请
    Low Dose Pharmaceutical Powders for Inhalation 审中-公开
    低剂量药用粉末吸入

    公开(公告)号：US20150114392A1

    公开(公告)日：2015-04-30

    申请号：US14531217

    申请日：2014-11-03

    申请人： Civitas Therapeutics, Inc.

    发明人： Jeffrey S. Hrkach

    IPC分类号： A61M15/00 ,  A61M15/08

    CPC分类号： A61M15/0091 ,  A61K9/0075 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/0086 ,  A61M15/08 ,  A61M2202/064 ,  A61M2206/16 ,  A61M2209/02

    摘要： The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein.

    摘要翻译： 本发明涉及一种在单次呼吸激活步骤中将药剂递送至受损患者的肺系统的方法，包括从含有少于5毫克质量的吸入器施用包含药剂的颗粒物质，其中至少 容器中约50％的质量被输送到患者的肺部系统。 本发明还涉及包含用于其中的颗粒物质和吸入器的容器。

    Capsules Containing High Doses of Levodopa for Pulmonary Use
    7.
    发明申请
    Capsules Containing High Doses of Levodopa for Pulmonary Use 有权
    含高剂量左旋多巴用于肺部使用的胶囊

    公开(公告)号：US20140220119A1

    公开(公告)日：2014-08-07

    申请号：US14174179

    申请日：2014-02-06

    申请人： Civitas Therapeutics, Inc.

    发明人： Kevin D. Kee ,  Ernest D. Penachio ,  Abhijit Kamerhar ,  Michael M. Lipp ,  Richard P. Batycky

    IPC分类号： A61K9/48 ,  A61K31/198

    CPC分类号： A61K9/4858 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/4808 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/198

    摘要： The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.

    摘要翻译： 本发明提供了含有可吸入粉末组合物的胶囊，其中组合物包含约75重量％或更多的左旋多巴，二棕榈酰磷脂酰胆碱（DPPC）和以小于约100g / L的工作密度为特征的盐。 本发明还提供一种含有可吸入粉末组合物的胶囊，其中所述组合物包含约75重量％或更多的左旋多巴，二棕榈酰磷脂酰胆碱（DPPC）和以小于约100g / L的工作密度为特征的盐，其中胶囊材料包含羟丙基甲基纤维素 （HPMC）和二氧化钛。

    DEVICES AND METHODS FOR PUNCTURING A CAPSULE TO RELEASE A POWDERED MEDICAMENT THEREFROM
    8.
    发明申请
    DEVICES AND METHODS FOR PUNCTURING A CAPSULE TO RELEASE A POWDERED MEDICAMENT THEREFROM 审中-公开
    用于调整胶囊以释放其中的粉末药物的装置和方法

    公开(公告)号：US20140150787A1

    公开(公告)日：2014-06-05

    申请号：US13719598

    申请日：2012-12-19

    申请人： CIVITAS THERAPEUTICS, INC.

    发明人： Colleen Ellwanger ,  Brian Noble ,  Tim Coker ,  Sean Plunkett

    IPC分类号： A61M15/00

    摘要： A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.

    摘要翻译： 用于刺穿胶囊以释放粉末状药物的装置包括用于接收胶囊的腔室。 胶囊包括相对的圆顶和由胶囊壁半径r限定的圆柱形壁部分。 该装置还包括用于刺穿至少一个穹顶中的至少一个孔的机构。 每个孔的中心位于不小于0.4r的环形穿刺区域内，并且所有穿刺孔的总表面积在胶囊的总表面积的约0.5％至约2.2％之间。 环形穿刺区域可以例如位于约0.4r至约0.8r之间，或约0.4r至约0.6r之间。