公开(公告)号：US20120219643A1

公开(公告)日：2012-08-30

申请号：US13440496

申请日：2012-04-05

申请人： Linda Saxe Einbond ,  Morando Soffritti ,  I. Bernard Weinstein ,  Joan Weinstein ,  Tamara Weinstein ,  Claudia Weinstein ,  Matthew Weinstein

发明人： Linda Saxe Einbond ,  Morando Soffritti ,  I. Bernard Weinstein ,  Joan Weinstein ,  Tamara Weinstein ,  Claudia Weinstein ,  Matthew Weinstein

IPC分类号： A61K36/71 ,  C12N5/09 ,  C12N5/071 ,  A61P35/00 ,  A61K31/7048

CPC分类号： A61K31/7048 ,  A61K36/71 ,  A61K45/06 ,  A61K2300/00

摘要： A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating Na+K+ATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.

摘要翻译： 通过施用协同量的洋地黄毒苷和任意一种肌动蛋白或包含三萜糖苷的黑加索提取物，以及任选的另一种可能是紫杉醇的化学预防剂，提供了治疗，预防或改善乳腺癌的方法。 还提供了使用协同组合治疗或预防肿瘤的方法，以及强心苷和任意一种肌动蛋白或包含三萜糖苷的黑加索提取物的协同组合的组合物，以及任选的另一种可能是紫杉烷的化学预防剂。 组合物也可用于调节Na + K + ATP酶活性的方法。 此外，提供了通过施用包含三萜糖苷和任选的至少一种其它化学保护剂的肌动蛋白或黑加索提取物来抑制体内乳腺癌进展或发展的方法。

公开(公告)号：US20120208776A1

公开(公告)日：2012-08-16

申请号：US13440655

申请日：2012-04-05

申请人： Linda Saxe Einbond ,  Morando Soffritti ,  Kyle Louis Kolaja ,  Richard John Brennan ,  I. Bernard Weinstein ,  Joan Weinstein ,  Tamara Weinstein ,  Claudia Weinstein ,  Matthew Weinstein

发明人： Linda Saxe Einbond ,  Morando Soffritti ,  Kyle Louis Kolaja ,  Richard John Brennan ,  I. Bernard Weinstein ,  Joan Weinstein ,  Tamara Weinstein ,  Claudia Weinstein ,  Matthew Weinstein

IPC分类号： A61K31/7048 ,  C12N9/99 ,  A61P35/00

CPC分类号： A61K31/704 ,  A61K31/7048 ,  A61K36/71 ,  A61K45/06 ,  A61K2300/00

摘要： A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.

摘要翻译： 提供一种用于治疗，预防或改善受试者中的瘤形成的方法。 该方法包括向受试者施用一定量的肌动蛋白或含有三萜糖苷的黑加索提取物的量，所述三萜糖苷的量与所述肌动蛋白或黑加索的量有效地用于治疗，预防或改善瘤形成， 的他汀类药物有效治疗，预防或改善肿瘤。 还提供了治疗，预防或改善乳腺癌或肝细胞瘤形成的相关方法。 此外，提供了调节受试者中胆固醇生物合成途径和应激反应途径的方法。 这些方法包括向受试者施用包含抗肿瘤协同量的他汀和actein的组合物。 还提供了用于实施这些方法的组合物。

公开(公告)号：US20090264377A1

公开(公告)日：2009-10-22

申请号：US12288599

申请日：2008-10-21

申请人： Linda Saxe Einbond ,  Morando Soffritti ,  Kyle Louis Kolaja ,  Richard John Brennan ,  I. Bernard Weinstein ,  Joan Weinstein ,  Tamara Weinstein ,  Claudia Weinstein ,  Matthew Weinstein

发明人： Linda Saxe Einbond ,  Morando Soffritti ,  Kyle Louis Kolaja ,  Richard John Brennan ,  I. Bernard Weinstein ,  Joan Weinstein ,  Tamara Weinstein ,  Claudia Weinstein ,  Matthew Weinstein

IPC分类号： A61K31/7048 ,  A61P35/00 ,  A61K31/366 ,  A61K31/4418 ,  A61K31/40 ,  A61K31/404 ,  A61K31/337

CPC分类号： A61K31/704 ,  A61K31/7048 ,  A61K36/71 ,  A61K45/06 ,  A61K2300/00

摘要： A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.

摘要翻译： 提供一种用于治疗，预防或改善受试者中的瘤形成的方法。 该方法包括向受试者施用一定量的肌动蛋白或含有三萜糖苷的黑加索提取物的量，所述三萜糖苷的量与所述肌动蛋白或黑加索的量有效地用于治疗，预防或改善瘤形成， 的他汀类药物有效治疗，预防或改善肿瘤。 还提供了治疗，预防或改善乳腺癌或肝细胞瘤形成的相关方法。 此外，提供了调节受试者中胆固醇生物合成途径和应激反应途径的方法。 这些方法包括向受试者施用包含抗肿瘤协同量的他汀和actein的组合物。 还提供了用于实施这些方法的组合物。