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公开(公告)号：US20110287437A1
公开(公告)日：2011-11-24
申请号：US12713962
申请日：2010-05-20
申请人： Hans Marcus Ludwig Bitter , Kyle Louis Kolaja , Preeti Dhawan , Hirdesh Uppal , Rama Rajaraja Varma
发明人： Hans Marcus Ludwig Bitter , Kyle Louis Kolaja , Preeti Dhawan , Hirdesh Uppal , Rama Rajaraja Varma
CPC分类号： G01N33/5047 , G01N33/5014 , G01N2500/10
摘要： The likelihood that a compound will exhibit cardiotoxicity in vivo can be predicted using a model of in vitro assays performed on primary human cardiomyocytes.
摘要翻译： 可以使用在原代人心肌细胞上进行的体外测定的模型来预测化合物在体内显示心脏毒性的可能性。
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公开(公告)号：US20120208776A1
公开(公告)日：2012-08-16
申请号：US13440655
申请日：2012-04-05
申请人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
发明人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
IPC分类号： A61K31/7048 , C12N9/99 , A61P35/00
CPC分类号： A61K31/704 , A61K31/7048 , A61K36/71 , A61K45/06 , A61K2300/00
摘要： A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.
摘要翻译： 提供一种用于治疗，预防或改善受试者中的瘤形成的方法。 该方法包括向受试者施用一定量的肌动蛋白或含有三萜糖苷的黑加索提取物的量，所述三萜糖苷的量与所述肌动蛋白或黑加索的量有效地用于治疗，预防或改善瘤形成， 的他汀类药物有效治疗，预防或改善肿瘤。 还提供了治疗，预防或改善乳腺癌或肝细胞瘤形成的相关方法。 此外，提供了调节受试者中胆固醇生物合成途径和应激反应途径的方法。 这些方法包括向受试者施用包含抗肿瘤协同量的他汀和actein的组合物。 还提供了用于实施这些方法的组合物。
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公开(公告)号：US20090181415A1
公开(公告)日：2009-07-16
申请号：US12339499
申请日：2008-12-19
申请人： Hans Marcus Ludwig Bitter , David Michael Goldstein , Nina Gonzaludo , Stephan Kirchner , Kyle Louis Kolaja , Andrew James Olaharski
发明人： Hans Marcus Ludwig Bitter , David Michael Goldstein , Nina Gonzaludo , Stephan Kirchner , Kyle Louis Kolaja , Andrew James Olaharski
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , G01N33/5014
摘要： The likelihood that a compound will exhibit genotoxicity in a micronucleus test is predicted by the ability of the compound to inhibit a plurality of kinases from a selected group.
摘要翻译： 化合物在微核试验中表现出遗传毒性的可能性是通过化合物抑制来自选定组的多种激酶的能力来预测的。
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公开(公告)号：US20110212461A1
公开(公告)日：2011-09-01
申请号：US12713976
申请日：2010-02-26
CPC分类号： C12Q1/485 , G01N2500/00
摘要： The likelihood that a compound will exhibit cardiotoxicity in an in vitro or in vivo assay predicted by the ability of the compound to inhibit at least one kinase from a selected group.
摘要翻译： 化合物在通过化合物抑制来自所选组的至少一种激酶的能力的体外或体内测定中显示心脏毒性的可能性。
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公开(公告)号：US20090264377A1
公开(公告)日：2009-10-22
申请号：US12288599
申请日：2008-10-21
申请人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
发明人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
IPC分类号： A61K31/7048 , A61P35/00 , A61K31/366 , A61K31/4418 , A61K31/40 , A61K31/404 , A61K31/337
CPC分类号： A61K31/704 , A61K31/7048 , A61K36/71 , A61K45/06 , A61K2300/00
摘要： A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.
摘要翻译： 提供一种用于治疗，预防或改善受试者中的瘤形成的方法。 该方法包括向受试者施用一定量的肌动蛋白或含有三萜糖苷的黑加索提取物的量，所述三萜糖苷的量与所述肌动蛋白或黑加索的量有效地用于治疗，预防或改善瘤形成， 的他汀类药物有效治疗，预防或改善肿瘤。 还提供了治疗，预防或改善乳腺癌或肝细胞瘤形成的相关方法。 此外，提供了调节受试者中胆固醇生物合成途径和应激反应途径的方法。 这些方法包括向受试者施用包含抗肿瘤协同量的他汀和actein的组合物。 还提供了用于实施这些方法的组合物。
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公开(公告)号：US20110212480A1
公开(公告)日：2011-09-01
申请号：US12713985
申请日：2010-02-26
申请人： Kyle Louis Kolaja , Preeti Dhawan , Hirdesh Uppal
发明人： Kyle Louis Kolaja , Preeti Dhawan , Hirdesh Uppal
IPC分类号： C12Q1/02
CPC分类号： G01N33/5061
摘要： The present invention provides for the use of primary human cardiomyocytes for the testing of agents that have cardiotoxic effects and other modulatory effects on the heart.
摘要翻译： 本发明提供了使用原代人心肌细胞来测试对心脏具有心脏毒性作用和其它调节作用的药剂。
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公开(公告)号：US20090208991A1
公开(公告)日：2009-08-20
申请号：US12378437
申请日：2009-02-12
申请人： Hans Marcus Ludwig Bitter , David Michael Goldstein , Kyle Louis Kolaja , Henry Lin , Andrew James Olaharski , Hirdesh Uppal
发明人： Hans Marcus Ludwig Bitter , David Michael Goldstein , Kyle Louis Kolaja , Henry Lin , Andrew James Olaharski , Hirdesh Uppal
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , G01N33/573
摘要： The likelihood that a compound will exhibit bone marrow toxicity in an in vivo assay predicted by the ability of the compound to inhibit at least eight kinases from a selected group.
摘要翻译： 化合物在通过化合物抑制来自所选组的至少8种激酶的能力预测的体内测定中显示出骨髓毒性的可能性。
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