公开(公告)号：US20090136421A1

公开(公告)日：2009-05-28

申请号：US12285767

申请日：2008-10-14

申请人： Marie Ranson ,  Barry John Allen ,  Clive Leighton Bunn

发明人： Marie Ranson ,  Barry John Allen ,  Clive Leighton Bunn

IPC分类号： A61K51/08 ,  A61P35/00

CPC分类号： C07K14/8132 ,  A61K38/00

摘要： A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.

公开(公告)号：US07998934B2

公开(公告)日：2011-08-16

申请号：US12285767

申请日：2008-10-14

申请人： Marie Ranson ,  Barry John Allen ,  Clive Leighton Bunn

发明人： Marie Ranson ,  Barry John Allen ,  Clive Leighton Bunn

IPC分类号： A01N61/00 ,  A61K38/00 ,  A61K49/00 ,  A61K51/00 ,  A61M36/14

CPC分类号： C07K14/8132 ,  A61K38/00

摘要： A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.

摘要翻译： 描述了一种用于检测，可视化或治疗表达uPA / uPAR复合物的细胞，特别是癌细胞的方法。 该方法采用包含PAI-2或PAI-2与毒素或标记物结合，连接或以其他方式结合的功能衍生物，同系物，类似物，化学等同物或模拟物的PAI-2共轭分子。

公开(公告)号：US07547441B2

公开(公告)日：2009-06-16

申请号：US09790900

申请日：2001-02-23

申请人： Marie Ranson ,  Barry John Allen ,  Clive Leighton Bunn

发明人： Marie Ranson ,  Barry John Allen ,  Clive Leighton Bunn

IPC分类号： A61K39/385 ,  A61K35/58 ,  C12Q1/26 ,  C12N5/06 ,  C12N5/00 ,  G01N23/00 ,  G01N33/48

CPC分类号： C07K14/8132 ,  A61K38/00

摘要： A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.

公开(公告)号：US06288025B1

公开(公告)日：2001-09-11

申请号：US09368164

申请日：1999-08-05

申请人： Clive Leighton Bunn ,  Phillip John Sharp

发明人： Clive Leighton Bunn ,  Phillip John Sharp

IPC分类号： A61K3800

CPC分类号： A61K38/57

摘要： Psoriasis may be treated by topical administration of a urokinase inhibitor, such as PAI-2, or a combination of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such as inhibitors of metalloproteinases, acid proteases, and thiol proteases.

摘要翻译： 牛皮癣可以通过局部施用尿素激酶抑制剂如PAI-2或蛋白酶抑制剂如PAI-2与其它丝氨酸蛋白酶抑制剂和/或与蛋白酶抑制剂如金属蛋白酶抑制剂，酸性蛋白酶， 和硫醇蛋白酶。

公开(公告)号：US06344189B1

公开(公告)日：2002-02-05

申请号：US09190451

申请日：1998-11-13

申请人： Clive Leighton Bunn ,  John Lewis Andrews ,  Phillip John Sharp

发明人： Clive Leighton Bunn ,  John Lewis Andrews ,  Phillip John Sharp

IPC分类号： A61K3174

CPC分类号： A61K38/06 ,  A61K38/57 ,  Y10S514/944

摘要： The healing of chronic wounds, such as leg ulcers, is accelerated via topical administration of a serine protease inhibitor, such as PAI-2. Wound healing also is promoted using combinations of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such inhibitors of metalloproteinases, acid proteases, and thiol proteases, respectively.

摘要翻译： 通过局部施用丝氨酸蛋白酶抑制剂如PAI-2，加速慢性伤口（例如腿部溃疡）的愈合。 使用蛋白酶抑制剂如PAI-2与其他丝氨酸蛋白酶抑制剂和/或蛋白酶抑制剂分别与金属蛋白酶，酸性蛋白酶和硫醇蛋白酶的抑制剂组合来促进伤口愈合。