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公开(公告)号：US07786100B2
公开(公告)日：2010-08-31
申请号：US11384579
申请日：2006-03-20
IPC分类号： A61K31/355 , A61K31/60 , A61P27/16
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，该组合物也是有效的。
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公开(公告)号：US20100305075A1
公开(公告)日：2010-12-02
申请号：US12839245
申请日：2010-07-19
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，该组合物也是有效的。
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公开(公告)号：US08053424B2
公开(公告)日：2011-11-08
申请号：US12839245
申请日：2010-07-19
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，该组合物也是有效的。
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公开(公告)号：US20070219167A1
公开(公告)日：2007-09-20
申请号：US11384579
申请日：2006-03-20
IPC分类号： A61K31/355 , A61K31/60
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，组合物也是有效的。
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