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公开(公告)号：US08338398B2
公开(公告)日：2012-12-25
申请号：US13091931
申请日：2011-04-21
申请人： Josef Miller , Colleen LePrell , Jochen Schact , Diane Prieskorn
发明人： Josef Miller , Colleen LePrell , Jochen Schact , Diane Prieskorn
IPC分类号： A61K33/06 , A61K31/355 , A61K31/60 , A61K31/07 , A61K31/375 , A61K31/245
CPC分类号： A61K9/0046 , A61K9/0019 , A61K31/015 , A61K31/07 , A61K31/355 , A61K31/375 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用以提供等于或大于各个组分的作用之和的叠加效应的组分。 组合物包含生物有效量的至少一种单线态氧清除剂，供体抗氧化剂，第三抗氧化剂和血管扩张剂。 治疗听力损失的方法包括在创伤后三天内向哺乳动物内部施用包含生物有效量的至少一种单线态清除剂，供体抗氧化剂，第三抗氧化剂和血管扩张剂的组合物的步骤 哺乳动物的中耳或内耳。
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2.发明授权公开(公告)号：US08338397B2
公开(公告)日：2012-12-25
申请号：US12761121
申请日：2010-04-15
申请人： Josef Miller
发明人： Josef Miller
IPC分类号： A61K33/06 , A61K31/355 , A61K31/60 , A61K31/07 , A61K31/375 , A61K31/245
CPC分类号： A61K31/355 , A61K31/05 , A61K31/07 , A61K31/341 , A61K31/375 , A61K33/00 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： A method of treating side effects of antibiotic treatment includes the step of internally administering an antibiotic that is capable of inducing hearing loss in a mammal. The method further includes the step of internally administering a composition to the mammal in conjunction with administration of the antibiotic. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, vitamin E, vitamin C, and a vasodilator comprising magnesium. The combination of vitamins and the vasodilator comprising magnesium, in the biologically effective amounts, provides an effective treatment for treating side effects of antibiotic treatment.
摘要翻译： 治疗抗生素治疗副作用的方法包括在哺乳动物内部施用能够引起听力损失的抗生素的步骤。 该方法还包括与哺乳动物联合给哺乳动物内部施用组合物的步骤。 组合物包括生物有效量的至少一种单线态氧清除剂，维生素E，维生素C和包含镁的血管扩张剂。 维生素和包含镁的血管扩张剂在生物有效量中的组合提供了治疗抗生素治疗副作用的有效治疗方法。
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公开(公告)号：US07786100B2
公开(公告)日：2010-08-31
申请号：US11384579
申请日：2006-03-20
IPC分类号： A61K31/355 , A61K31/60 , A61P27/16
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，该组合物也是有效的。
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公开(公告)号：US06634414B2
公开(公告)日：2003-10-21
申请号：US10163337
申请日：2002-06-07
申请人： Josef Miller
发明人： Josef Miller
IPC分类号： B22D1710
CPC分类号： B22D17/26
摘要： A pressure die casting machine is provided for processing fused metals in which the die locking unit is mounted adjustably on a lifting frame that can be vertically raised or lowered to adapt the die locking unit to the casting nozzle via lever sets and a common mechanical adjusting device for these lever sets. This arrangement achieves a space-saving arrangement with a simplified design.
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公开(公告)号：US20100305075A1
公开(公告)日：2010-12-02
申请号：US12839245
申请日：2010-07-19
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，该组合物也是有效的。
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公开(公告)号：US07700134B2
公开(公告)日：2010-04-20
申请号：US10345802
申请日：2003-01-16
申请人： Goran Laurell , Andreas Ekborn , Josef Miller , Hans Ehrsson
发明人： Goran Laurell , Andreas Ekborn , Josef Miller , Hans Ehrsson
CPC分类号： A61K31/17 , A61K33/24 , A61K2300/00
摘要： The present invention relates to compositions and methods for the protection and restoration of hearing. In particular, the present invention relates to methods and compositions for the prevention of chemical (e.g., cisplatin) induced deafness. The present invention thus provides methods of improving the outcome of subjects treated with cisplatin.
摘要翻译： 本发明涉及用于保护和恢复听力的组合物和方法。 特别地，本发明涉及用于预防化学（例如顺铂）诱导的耳聋的方法和组合物。 因此，本发明提供了改善用顺铂治疗的受试者的结果的方法。
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公开(公告)号：US08053424B2
公开(公告)日：2011-11-08
申请号：US12839245
申请日：2010-07-19
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，该组合物也是有效的。
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公开(公告)号：US07951845B2
公开(公告)日：2011-05-31
申请号：US11623888
申请日：2007-01-17
申请人： Josef Miller , Colleen LePrell , Jochen Schacht , Diane Prieskorn
发明人： Josef Miller , Colleen LePrell , Jochen Schacht , Diane Prieskorn
IPC分类号： A61K31/07 , A61K31/245 , A61K31/60 , A61K8/19 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/0019 , A61K31/015 , A61K31/07 , A61K31/355 , A61K31/375 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用以提供等于或大于各个组分的作用之和的叠加效应的组分。 组合物包含生物有效量的至少一种单线态氧清除剂，供体抗氧化剂，第三抗氧化剂和血管扩张剂。 治疗听力损失的方法包括在创伤后三天内向哺乳动物内部施用包含生物有效量的至少一种单线态清除剂，供体抗氧化剂，第三抗氧化剂和血管扩张剂的组合物的步骤 哺乳动物的中耳或内耳。
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9.发明申请公开(公告)号：US20100203169A1
公开(公告)日：2010-08-12
申请号：US12761121
申请日：2010-04-15
申请人： Josef Miller
发明人： Josef Miller
CPC分类号： A61K31/355 , A61K31/05 , A61K31/07 , A61K31/341 , A61K31/375 , A61K33/00 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： A method of treating side effects of antibiotic treatment includes the step of internally administering an antibiotic that is capable of inducing hearing loss in a mammal. The method further includes the step of internally administering a composition to the mammal in conjunction with administration of the antibiotic. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, vitamin E, vitamin C, and a vasodilator comprising magnesium. The combination of vitamins and the vasodilator comprising magnesium, in the biologically effective amounts, provides an effective treatment for treating side effects of antibiotic treatment.
摘要翻译： 治疗抗生素治疗副作用的方法包括在哺乳动物内部施用能够引起听力损失的抗生素的步骤。 该方法还包括与哺乳动物联合给哺乳动物内部施用组合物的步骤。 组合物包括生物有效量的至少一种单线态氧清除剂，维生素E，维生素C和包含镁的血管扩张剂。 维生素和包含镁的血管扩张剂在生物有效量中的组合提供了治疗抗生素治疗副作用的有效治疗方法。
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公开(公告)号：US20070219167A1
公开(公告)日：2007-09-20
申请号：US11384579
申请日：2006-03-20
IPC分类号： A61K31/355 , A61K31/60
CPC分类号： A61K45/06 , A61K31/355 , A61K31/60 , A61K2300/00
摘要： A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.
摘要翻译： 用于治疗听力损失的组合物包括通过不同生物机制起作用的组分，以提供大于单独组分的作用的加成效应。 该组合物包括生物有效量的维生素E，用于抑制有助于听力损失的脂质过氧化的增殖。 该组合物还包括生物有效量的水杨酸盐，用于还原有助于听力损失的羟基自由基。 治疗听力损失的方法包括如下所述在哺乳动物的中耳或内耳创伤后三天内向哺乳动物内部施用组合物的步骤。 换句话说，即使在对哺乳动物的中耳或内耳的创伤后三天施用，组合物也是有效的。
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