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    CORTISTATIN OR AN ANALOGUE THEREOF AS A PHARMACEUTICALLY ACTIVE AGENT IN LATENT FORM
    2.
    发明申请
    CORTISTATIN OR AN ANALOGUE THEREOF AS A PHARMACEUTICALLY ACTIVE AGENT IN LATENT FORM 有权

    公开(公告)号：US20220135640A1

    公开(公告)日：2022-05-05

    申请号：US17431082

    申请日：2020-02-17

    申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

    发明人： Mario DELGADO MORA ,  Jenny CAMPOS SALINAS

    IPC分类号： C07K14/655 ,  A61P17/00 ,  A61P11/00 ,  A61P1/16

    摘要： The blood half-life of endogenous peptides such as somatostatin and cortistatin is extremely short, barely reaching a few In minutes [Skamene et al., Clin. Endocrinol. 1984, 20, 555-564]. Thus, there is a need to find new systems or compositions that comprise cortistatinor an analogue thereof for the treatment of those pathologies in which specific cortistatin receptors and those receptors shared with other molecules like somatostatin (sstr1, sstr2, sstr3, sstr4 and/or sstr5) and/or ghrelin (GHSR) are expressed, being, furthermore, more stable in blood than cortistatin. The present invention providesan improved means for providing cortistatinor an analogue thereof as a pharmaceutically active agent in latent form, more stable in blood than cortistatin that liberates cortistatin in a controlled-release manner.

    CHIMERIC PROTEIN SWITCH FOR THE OPTOGENETIC CONTROL OF AMYLOIDOGENESIS
    3.
    发明申请
    CHIMERIC PROTEIN SWITCH FOR THE OPTOGENETIC CONTROL OF AMYLOIDOGENESIS 有权

    公开(公告)号：US20220056084A1

    公开(公告)日：2022-02-24

    申请号：US17298911

    申请日：2019-12-03

    申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

    发明人： Rafael GIRALDO SUÁREZ

    IPC分类号： C07K14/415 ,  C07K14/195

    摘要： The present invention provides an optogenetic chimeric fusion polypeptide comprising an optimized amino acid sequence of the plant phototropin domain LOV2 fused to an amino acid sequence of the bacterial amyloidogenic effector RepA-WH1. Optimized LOV2 enables navigation through the folding landscape of RepA-WH1 from solubility to its aggregation as oligomers or amyloid fibres. Thus, this polypeptide assembles as hydrogels and amyloid fibres in the darkness, while under blue light illumination forms oligomeric particles that are proteotoxic for cells, preferably bacteria. This polypeptide is therefore proposed for inducing the formation of cytotoxic amyloid oligomers in cells that are targeted for killing.

    Reactor for Heating a Gas and Uses Thereof
    6.
    发明申请
    Reactor for Heating a Gas and Uses Thereof 有权

    公开(公告)号：US20210197158A1

    公开(公告)日：2021-07-01

    申请号：US17058415

    申请日：2019-05-27

    申请人： Consejo Superior de Investigaciones Cientificas (CSIC)

    发明人： Juan Carlos ABANADES GARCIA

    IPC分类号： B01J8/02

    摘要： This invention discloses a reactor and methods for heating of a gas as it reacts with a solid. The reactor contains gas conducts that are empty of solids and that cross through a region packed with solids. The wall of the gas conducts has orifices to make it permeable but not selective to gases, while effectively separating the solids from the gas. In the reactor, the heat source to heat up the gas is generated by the exothermic reaction of the solids with one active component of the gas. The region packed with the reacting solids is at temperatures ranging from 500° C. to 1500° C., to promote the heat transfer towards the gas and the high reactivity of the solids with the active components of the gas, that is forced to diffuse from the conduct through the orifices of the conduct wall.