公开(公告)号：USRE38314E1

公开(公告)日：2003-11-11

申请号：US09292484

申请日：1999-04-15

申请人： John W. Ager ,  Craig A. Polsz

发明人： John W. Ager ,  Craig A. Polsz

IPC分类号： C07D24912

CPC分类号： C07D249/12

摘要： A process is disclosed for the preparation of the herbicide ethyl &agr;-2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropionate by the simultaneous diazotization of 4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1-(5-amino-2-fluoro-4-chloro-phenyl)-1H-1,2,4-triazole (the Amine) and arylation of ethyl acrylate with the diazotized Amine. In the process the following reagents are added in sequence and, under specified conditions, to a cooled, stirred solution of the Amine in acetone: cuprous chloride, hydrochloric acid, ethyl acrylate, and sodium nitrite.

公开(公告)号：US5468868A

公开(公告)日：1995-11-21

申请号：US168737

申请日：1993-12-16

申请人： Marc Halfon ,  Craig A. Polsz ,  John H. Hoare

发明人： Marc Halfon ,  Craig A. Polsz ,  John H. Hoare

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： This invention provides a process for optimizing the yield of a 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one by the chlorination in two steps of a 4,5-dihydro-1-phenyl-1H-1,2,4-triazol-5-one. The critical first step is the selective chlorination of the phenyl ring in the 4-position by addition of chlorine to a solution of the 4,5-dihydro-1-phenyl-1H-1,2,4-triazol-5-one in N,N-dimethylformamide. Chlorination of the product of the first step in acetic acid/water yields the 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one in high yield.

摘要翻译： 本发明提供了一种通过氯化分离得到1-（2,4-二氯苯基）-4,5-二氢-1H-1,2,4-三唑-5-酮的产率的方法， 5-二氢-1-苯基-1H-1,2,4-三唑-5-酮。 关键的第一步是通过向4,5-二氢-1-苯基-1H-1,2,4-三唑-5-酮的溶液中加入氯而在4-位上苯基环的选择性氯化 N，N-二甲基甲酰胺。 在乙酸/水中的第一步产物的氯化得到高产率的1-（2,4-二氯苯基）-4,5-二氢-1H-1,2,4-三唑-5-酮。

公开(公告)号：US20090043117A1

公开(公告)日：2009-02-12

申请号：US11816105

申请日：2006-02-16

申请人： Jaidev S. Goudar ,  Charles E. Hatch, III ,  Guozhi Wang ,  Russell Patera ,  Craig A. Polsz

发明人： Jaidev S. Goudar ,  Charles E. Hatch, III ,  Guozhi Wang ,  Russell Patera ,  Craig A. Polsz

IPC分类号： C07D307/78

CPC分类号： C07D307/79

摘要： An improved process is described for preparing (disubstitutedpropenyl) phenylalkyl substituted dihydrobenzofurans. This improved process is focused on steps to produce key intermediates, namely compounds of Formula (I): where R3, R4, R5, R6 and x are defined herein.

摘要翻译： 描述了制备（二取代的丙烯基）苯基烷基取代的二氢苯并呋喃的改进方法。 这种改进的方法集中在产生关键中间体的步骤，即式（I）的化合物：其中R3，R4，R5，R6和x如本文所定义。

公开(公告)号：US5621112A

公开(公告)日：1997-04-15

申请号：US683444

申请日：1996-07-18

申请人： John W. Ager ,  Craig A. Polsz

发明人： John W. Ager ,  Craig A. Polsz

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： A process is disclosed for the preparation of the herbicide ethyl .alpha.-2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropionate by the simultaneous diazotization of 4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1-(5-amino-2-fluoro-4-chloro-phenyl)-1H-1,2,4-triazole (the Amine) and arylation of ethyl acrylate with the diazotized Amine. In the process the following reagents are added in sequence and, under specified conditions, to a cooled, stirred solution of the Amine in acetone: cuprous chloride, hydrochloric acid, ethyl acrylate, and sodium nitrite.

摘要翻译： 公开了一种制备除草剂乙基-2-二氯-5- [4-（二氟甲基）-4,5-二氢-3-甲基-5-氧代-1H-1,2,4-三唑-1-基的制备方法， 吡啶-1-基] -4-氟苯丙酸乙酯，同时重氮化4-二氟甲基-4,5-二氢-3-甲基-5-氧代-1-（5-氨基-2-氟-4-氯-4-苯基） - 1H-1,2,4-三唑（胺）和丙烯酸乙酯与重氮化胺的芳基化。 在此过程中，按照规定的条件，将下列试剂加入冷却的搅拌下的丙酮：丙酮：氯化亚铜，盐酸，丙烯酸乙酯和亚硝酸钠的溶液中。