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    Aminotriazole compounds
    2.
    发明授权
    Aminotriazole compounds 失效
    氨基三唑化合物

    公开(公告)号：US06245916B1

    公开(公告)日：2001-06-12

    申请号：US09549745

    申请日：2000-04-14

    申请人： Jean-Luc Fauchere ,  Jean-Claude Ortuno ,  Jacques Duhault ,  Jean Albert Boutin ,  Nigel Levens

    发明人： Jean-Luc Fauchere ,  Jean-Claude Ortuno ,  Jacques Duhault ,  Jean Albert Boutin ,  Nigel Levens

    IPC分类号： C07D24912

    CPC分类号： C07D401/12 ,  C07D249/14 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： Compound of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted. A represents a grouping selected from —A2—, —A1—A2—, —A2—A1— and —A1—A2—A1— wherein A1 is alkylene and A2 represents phenylene, cycloalkylene, naphthylene or heteroarylene each optionally substituted, R represents hydrogen, alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkenyl each optionally substituted, R1 represents alkyl, aryl, heteroary, arylalkyl arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, and medicinal products containing the same which are useful as Neuropeptide Y receptor ligands.

    摘要翻译： 式（I）化合物：其中：n为0或1，W表示-CO-或S（O）q，q为0,1或2，G表示如上述定义的G1，G2，G3或G4基团 描述，Z代表烷基，芳基，杂芳基，芳基烷基，芳基烯基，芳基炔基，杂芳基烯基，杂芳基炔基或杂芳基烷基，各自任选取代.A代表选自-A2-，-A1-A2-，-A2-A1-和-A1- 其中A1是亚烷基，A2代表亚苯基，亚环烷基，亚萘基或亚杂芳基，各自任选取代，R代表氢，烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烯基， 芳基，芳基烷基芳基烯基，芳基炔基，杂芳基烯基，杂芳基炔基或各自任意取代的杂芳基烷基，以及含有该芳基的可药用神经肽Y受体配体的医药产品。

    Process for preparing triazolinethione derivatives
    3.
    发明授权
    Process for preparing triazolinethione derivatives 有权
    三唑啉酮衍生物的制备方法

    公开(公告)号：US06172236B2

    公开(公告)日：2001-01-09

    申请号：US09509901

    申请日：2000-04-04

    申请人： Manfred Jautelat ,  David Erdman

    发明人： Manfred Jautelat ,  David Erdman

    IPC分类号： C07D24912

    CPC分类号： C07D249/12

    摘要： According to a novel process, triazolinethione derivatives of the formula in which R1 and R2 are each as defined in the description can be prepared by reacting triazole derivatives of the formula  with sulphur in the presence of an aprotic polar diluent at temperatures between 140° C. and 160° C., where the amounts of the reaction components are chosen such that between 6 and 15 mol of sulphur are present per mole of triazole derivative of the formula (II), and where air is passed over the reaction mixture during the reaction.

    摘要翻译： 根据一个新方法，R1和R2各自如说明书中所定义的式的三唑啉酮衍生物可以通过在惰性极性稀释剂存在下，在140℃和160℃之间的温度下使下式的三唑衍生物与硫反应制备 ℃，其中选择反应组分的量使得每摩尔式（II）的三唑衍生物存在6至15摩尔的硫，并且其中空气在反应期间通过反应混合物。

    Process for the preparation of 1,2,4-triazolin-5-one derivatives
    4.
    发明授权
    Process for the preparation of 1,2,4-triazolin-5-one derivatives 失效
    制备1,2,4-三唑啉-5-酮衍生物的方法

    公开(公告)号：US06673939B2

    公开(公告)日：2004-01-06

    申请号：US10311389

    申请日：2003-02-05

    申请人： Cameron John Cowden

    发明人： Cameron John Cowden

    IPC分类号： C07D24912

    CPC分类号： C07D413/06 ,  C07D249/12

    摘要： The present invention relates to a process for the preparation of a compound of formula (I) wherein R represents hydrogen, C1-10alkyl, haloC1-10alkyl or aryl; which are useful intermediates in the preparation of morpholine derivatives of formula (A). Compounds of formula (A) are useful as therapeutic agents.

    摘要翻译： 本发明涉及制备式（I）化合物的方法，其中R代表氢，C1-10烷基，卤代C 1-10烷基或芳基; 其在制备式（A）的吗啉衍生物中是有用的中间体。 式（A）的化合物可用作治疗剂。

    Method for producing triazolinethione derivatives
    7.
    发明授权
    Method for producing triazolinethione derivatives 有权
    三唑啉酮衍生物的制备方法

    公开(公告)号：US06271389B1

    公开(公告)日：2001-08-07

    申请号：US09509889

    申请日：2000-04-03

    申请人： Reinhard Lantzsch ,  Manfred Jautelat ,  Achim Hupperts ,  David Erdman

    发明人： Reinhard Lantzsch ,  Manfred Jautelat ,  Achim Hupperts ,  David Erdman

    IPC分类号： C07D24912

    CPC分类号： C07D249/12

    摘要： According to a novel process, it is possible to prepare triazolinethione derivatives of the formula in which R1 and R2 are each as defined in the description by a) reacting hydrazine derivatives of the formula  with carbonyl compounds of the formula  in which R3 and R4 are each as defined in the description  with potassium thiocyanate, sodium thiocyanate or ammonium thiocyanate,  if appropriate in the presence of a diluent and if appropriate in the presence of an acid, and b) reacting the resulting triazolidinethione derivatives of the formula  with formic acid, if appropriate in the presence of a catalyst and if appropriate in the presence of a diluent. The triazolidinethione derivatives of the formula (V) are novel.

    摘要翻译： 根据一个新方法，可以制备式（Ⅲ）的三唑啉酮衍生物，其中R1和R2各自如说明书中所定义.a）使下式的肼衍生物与下式的羰基化合物反应：其中R 3和R 4各自如 如果在稀释剂存在下和适当的情况下在酸存在下，硫氰酸钠，硫氰酸钠或硫氰酸铵的描述，以及b）如果合适的话，在酸的存在下，将所得到的式I的三唑烷硫酮衍生物与甲酸反应， 催化剂，如果合适，则在稀释剂存在下。式（Ⅴ）的三唑烷酮二酮衍生物是新颖的。

    Process for manufacturing substituted triazolinones
    8.
    发明授权
    Process for manufacturing substituted triazolinones 有权
    制备取代的三唑啉酮的方法

    公开(公告)号：US06222045B1

    公开(公告)日：2001-04-24

    申请号：US09665092

    申请日：2000-09-20

    申请人： Dennis E. Jackman

    发明人： Dennis E. Jackman

    IPC分类号： C07D24912

    CPC分类号： C07D249/12

    摘要： The present invention relates to a process for manufacturing substituted triazolinones, which are intermediates in the preparation of herbicidally active compounds. In particular, this invention relates to the reaction of an isothiocyanate with an alkanol to produce a thionocarbamate intermediate product; alkylation of the intermediate product, reaction of the alkylated intermediate with and alkoxycarbobyl or aryloxycarbonyl hydrazine and reaction of the resultant compound with a base to produce a substituted triazolinone. In this context the terms “alkanol” and “alkylation” represent generic terms and thus, include the use of alkanols and alkylating agents having an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group or an arylalkyl group.

    摘要翻译： 本发明涉及制备取代三唑啉酮的方法，它是制备除草活性化合物的中间体。 特别地，本发明涉及异硫氰酸酯与链烷醇反应产生硫代氨基甲酸酯中间产物; 中间产物的烷基化，烷基化中间体与烷氧基羰基或芳氧基羰基肼的反应，并将所得化合物与碱反应，生成取代的三唑啉酮。 在本文中，术语“烷醇”和“烷基化”表示通用术语，因此包括使用具有烷基，链烯基，炔基，环烷基，环烷基烷基，芳基的烷醇和烷基化剂 或芳基烷基。

    Substituted benzoyl ketones, methods for producing them and their use as herbicides
    9.
    发明授权
    Substituted benzoyl ketones, methods for producing them and their use as herbicides 失效
    取代的苯甲酰基酮，其制备方法及其作为除草剂的用途

    公开(公告)号：US06762152B1

    公开(公告)日：2004-07-13

    申请号：US10009981

    申请日：2001-11-05

    申请人： Klaus-Helmut Müller ,  Stefan Lehr ,  Otto Schallner ,  Hans-Georg Schwarz ,  Heinz-Jürgen Wroblowsky ,  Mark Wilhelm Drewes ,  Dieter Feucht ,  Rolf Pontzen ,  Ingo Wetcholowsky

    发明人： Klaus-Helmut Müller ,  Stefan Lehr ,  Otto Schallner ,  Hans-Georg Schwarz ,  Heinz-Jürgen Wroblowsky ,  Mark Wilhelm Drewes ,  Dieter Feucht ,  Rolf Pontzen ,  Ingo Wetcholowsky

    IPC分类号： C07D24912

    CPC分类号： C07D209/48 ,  A01N43/653 ,  C07D213/64 ,  C07D231/20 ,  C07D233/70 ,  C07D237/32 ,  C07D239/10 ,  C07D249/12 ,  C07D249/14 ,  C07D253/04 ,  C07D263/58 ,  C07D275/06 ,  C07D285/13 ,  C07D471/04 ,  C07D487/04

    摘要： The invention relates to novel substituted benzoyl ketones of the formula (I) in which n represents 0, 1, 2 or 3, A represents a single bond or represents alkanediyl (alkylene), R1 represents hydrogen or represents in each case optionally substituted alkyl or cycloalkyl, R2 represents hydrogen, cyano, carbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulphinyl or alkylsulphonyl, R3 represents hydrogen, nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylamino, dialkylamino or dialkylaminosulphonyl, R4 represents nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylamino, dialkyiamino or dialkylaminosulphonyl, and Z represents an optionally substituted 4- to 12-membered, saturated or unsaturated, monocyclic or bicyclic, heterocyclic grouping which, contains 1 to 4 hetero atoms (up to 4 nitrogen atoms and optionally—alternatively or additionally—one oxygen atom or one sulphur atom, or one SO grouping or one SO2 grouping) and which additionally contains one to three oxo g of the heterocycle roups (C═O) and/or thioxo groups (C═S) as components, of the heterocycle, and to processes for their preparation and to their use as herbicides.

    摘要翻译： 本发明涉及式（I）的新的取代的苯甲酰基酮，其中n表示0,1,2或3，A表示单键或表示烷二基（亚烷基），R 1表示氢或表示在各种情况下任选取代 烷基或环烷基，R 2表示氢，氰基，氨基甲酰基，卤素，或在各自的情况下表示任选取代的烷基，烷氧基，烷氧基羰基，烷硫基，烷基亚磺酰基或烷基磺酰基，R 3表示氢，硝基，氰基，羧基，氨基甲酰基 ，硫代氨基甲酰基，卤素，或在每种情况下代表任选取代的烷基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基，二烷基氨基或二烷基氨基磺酰基，R 4表示硝基，氰基，羧基，氨基甲酰基，硫代氨基甲酰基，卤素，或在每种情况下 任选取代的烷基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基，二烷基氨基或二烷基氨基磺酰基，Z表示任选取代的4-至12-元饱和或不饱和 饱和的单环或双环杂环基，其含有1至4个杂原子（最多4个氮原子和任选地或另外一个氧原子或一个硫原子，或一个SO基团或一个SO 2基团），并且另外含有 杂环的一至三个氧代基团（C = O）和/或硫代基（C = S）作为组分，以及其制备方法及其作为除草剂的用途。