公开(公告)号：US20120184523A1

公开(公告)日：2012-07-19

申请号：US13427093

申请日：2012-03-22

Applicant: Lynne Canne Bannen ,  Diva Sze-Ming Chan ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Vasu Jammalamadaka ,  Richard George Khoury ,  James William Leahy ,  Morrison B. Mac ,  Grace Mann ,  Larry W. Mann ,  John M. Nuss ,  Jason Jevious Parks ,  Craig Stacy Takbuchi ,  Yong Wang ,  Wei Xu

Inventor： Lynne Canne Bannen ,  Diva Sze-Ming Chan ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Vasu Jammalamadaka ,  Richard George Khoury ,  James William Leahy ,  Morrison B. Mac ,  Grace Mann ,  Larry W. Mann ,  John M. Nuss ,  Jason Jevious Parks ,  Craig Stacy Takbuchi ,  Yong Wang ,  Wei Xu

IPC: A61K31/4709 ,  A61K31/517 ,  C07D215/233 ,  C07D401/12 ,  A61K31/47 ,  C07D239/94 ,  C07D417/12 ,  C07D401/10 ,  C07D413/12 ,  A61K31/5377 ,  C07D215/46 ,  C07D417/14 ,  A61K31/501 ,  A61K31/496 ,  A61K31/513 ,  C12N9/99 ,  C12Q1/48 ,  C12Q1/66 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P25/00 ,  A61P17/06 ,  A61P9/00 ,  A61P9/10 ,  A61P1/00 ,  A61P19/02 ,  A61P27/02 ,  C07D403/10

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D215/46 ,  C07D239/88 ,  C07D239/94 ,  C07D295/15 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C12Q1/485 ,  G01N2500/04 ,  Y02A50/393

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.