公开(公告)号：US20180271979A1

公开(公告)日：2018-09-27

申请号：US15926709

申请日：2018-03-20

Applicant: Diffusion Pharmaceuticals LLC

Inventor： John L. GAINER ,  Marc LANZ

IPC: A61K41/00 ,  A61N5/10 ,  C07C57/13 ,  C07C69/602 ,  C07C57/03 ,  A61K9/19 ,  A61K31/202 ,  A61K31/11 ,  A61K45/06

CPC classification number: A61K41/0038 ,  A61K9/19 ,  A61K31/11 ,  A61K31/202 ,  A61K45/06 ,  A61N5/10 ,  C07C57/03 ,  C07C57/13 ,  C07C69/602

Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

公开(公告)号：US20150352068A1

公开(公告)日：2015-12-10

申请号：US14642703

申请日：2015-03-09

Applicant: Diffusion Pharmaceuticals, LLC

Inventor： John L. Gainer ,  Robert MURRAY

IPC: A61K31/202 ,  A61K31/724

CPC classification number: A61K31/202 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K9/4891 ,  A61K31/724

Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.

Abstract translation: 本发明涉及双极性类胡萝卜素的各种制剂，包括用于口服递送双相反式类胡萝卜素的药物组合物，其包括i）双极性类胡萝卜素，ii）环糊精，和iii）包衣。 本发明还涉及这些制剂及其用途的制备。

公开(公告)号：US20040116729A1

公开(公告)日：2004-06-17

申请号：US10647132

申请日：2003-08-25

Applicant: Diffusion Pharmaceuticals LLC

Inventor： John L. Gainer ,  Raymond C. Grabiak

IPC: C07F009/02

CPC classification number: A61K31/202 ,  A61K9/0019 ,  A61K9/0053 ,  C07C57/13 ,  C07C69/602 ,  C07C305/14 ,  C07F9/113

Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

Abstract translation: 本发明涉及反式类胡萝卜素盐化合物，其制备方法，溶解方法及其用途。 这些化合物可用于改善包括人在内的哺乳动物的红细胞和身体组织之间的氧的扩散性。

公开(公告)号：US11278621B2

公开(公告)日：2022-03-22

申请号：US15926709

申请日：2018-03-20

Applicant: Diffusion Pharmaceuticals LLC

Inventor： John L. Gainer ,  Marc Lanz

IPC: A61K41/00 ,  A61K45/06 ,  A61K9/19 ,  A61K31/202 ,  A61K31/11 ,  A61N5/10 ,  C07C57/03 ,  C07C57/13 ,  C07C69/602

Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

公开(公告)号：US10016384B2

公开(公告)日：2018-07-10

申请号：US14642703

申请日：2015-03-09

Applicant: Diffusion Pharmaceuticals, LLC

Inventor： John L. Gainer ,  Robert Murray

IPC: A61K31/202 ,  A61K31/724 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48

CPC classification number: A61K31/202 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K9/4891 ,  A61K31/724

Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.

公开(公告)号：US09950067B2

公开(公告)日：2018-04-24

申请号：US14993047

申请日：2016-01-11

Applicant: Diffusion Pharmaceuticals, LLC

Inventor： John L. Gainer ,  Marc Lanz

IPC: A61K41/00 ,  A61K9/19 ,  A61K31/11 ,  A61K31/202 ,  A61K45/06 ,  A61N5/10 ,  C07C57/03 ,  C07C57/13 ,  C07C69/602

CPC classification number: A61K41/0038 ,  A61K9/19 ,  A61K31/11 ,  A61K31/202 ,  A61K45/06 ,  A61N5/10 ,  C07C57/03 ,  C07C57/13 ,  C07C69/602

Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

公开(公告)号：US20240316000A1

公开(公告)日：2024-09-26

申请号：US18575201

申请日：2022-06-29

Applicant: DIFFUSION PHARMACEUTICALS LLC

Inventor： Robert J. COBUZZI ,  Christopher D. GALLOWAY

IPC: A61K31/202 ,  A61P43/00

CPC classification number: A61K31/202 ,  A61P43/00

Abstract: Provided are novel methods of treatment of conditions such as peripheral tissue oxygenation, interstitial lung disease, dyspnea, ischemia from surgery, brain and pancreatic cancer with increased oxygen diffusivity comprising administering a diffusion enhancing compound, for example, trans sodium crocetinate.

公开(公告)号：US20230346733A1

公开(公告)日：2023-11-02

申请号：US18053193

申请日：2022-11-07

Applicant: Diffusion Pharmaceuticals LLC

Inventor： John L. Gainer ,  Robert Murray

IPC: A61K31/202 ,  A61K31/724 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48

CPC classification number: A61K31/202 ,  A61K31/724 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K9/4891

Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.

公开(公告)号：US20210244698A1

公开(公告)日：2021-08-12

申请号：US17264411

申请日：2019-07-30

Applicant: DIFFUSION PHARMACEUTICALS LLC

Inventor： David G. KALERGIS ,  Thomas BYRNE

IPC: A61K31/202 ,  A61K47/40 ,  A61K45/06 ,  A61K9/00 ,  A61B18/20

Abstract: The subject invention relates to novel methods for the rapid treatment of disorders resulting from thrombosis or embolism such as a myocardial infraction or stroke. Specifically, the invention relates to diffusion enhancing compounds and their use with embolectomy and thrombectomy, or other procedures for the treatment of ischemia.

公开(公告)号：US20140051759A1

公开(公告)日：2014-02-20

申请号：US13621650

申请日：2012-09-17

Applicant: Diffusion Pharmaceuticals LLC

Inventor： John L. Gainer ,  Raymond C. Grabiak

IPC: A61K31/194 ,  A61P7/00 ,  A61P11/00 ,  A61P9/00 ,  A61P25/28 ,  A61P11/06 ,  A61P25/00 ,  A61P7/10 ,  A61P35/00 ,  A61P3/10 ,  C07C45/67 ,  A61P9/10

CPC classification number: C07C69/602 ,  C07C57/13 ,  C07C305/14 ,  C07F9/113

Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

Abstract translation: 本发明涉及反式类胡萝卜素盐化合物，其制备方法，溶解方法及其用途。 这些化合物可用于改善包括人在内的哺乳动物的红细胞和身体组织之间的氧的扩散性。