公开(公告)号：US20140328939A1

公开(公告)日：2014-11-06

申请号：US14343629

申请日：2012-04-02

申请人： Da Yeon Kim ,  Moon Suk Kim ,  So Mi Yoon ,  Bit Na Lee

发明人： Da Yeon Kim ,  Moon Suk Kim ,  So Mi Yoon ,  Bit Na Lee

IPC分类号： A61K35/38 ,  A61K9/06

CPC分类号： A61K35/38 ,  A61K9/06 ,  A61K47/46 ,  A61L27/3629 ,  A61L27/3687 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/40

摘要： The present invention relates to a method for preparing a biocompatible small intestinal submucosa hydrogel with a controllable in-vivo degradation period, more particularly to a method for preparing a small intestinal submucosa hydrogel which is formed in a solution phase by forming chemical crosslinkages by solubilizing a biocompatible small intestinal submucosa powder and allows the degradation period of a gel formed during in-vivo injection by controlling the degree of crosslinking and a method for preparing a small intestine submucosa drug carrier or a small intestine submucosa support using the hydrogel.

摘要翻译： 本发明涉及一种制备具有可控的体内降解期的生物相容性小肠粘膜下层水凝胶的方法，更具体地涉及一种制备在溶液相中形成的小肠粘膜下层水凝胶的方法，该方法是通过溶解形成化学交联 生物相容性小肠粘膜下层粉末，并且通过控制交联度使得在体内注射期间形成的凝胶的降解期和使用该水凝胶的小肠粘膜下层药物载体或小肠粘膜下层支持物的制备方法。

公开(公告)号：US10307373B2

公开(公告)日：2019-06-04

申请号：US13022734

申请日：2011-02-08

申请人： Moon Suk Kim ,  Da Yeon Kim

发明人： Moon Suk Kim ,  Da Yeon Kim

IPC分类号： A61K9/10 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K47/34 ,  A61K38/00

摘要： Provided is a drug delivery system for control of initial burst of a drug. More particularly, there are provided a drug delivery formulation including: a granule containing a biodegradable polymer and a drug; and a temperature-sensitive hydrogel, and a method for preparing the same. The presently disclosed drug delivery formulation can be prepared via a relatively simple process and allows a drug to be released slowly at a constant rate without initial burst and thus maintains a constant blood level of the drug for a long period of time. Consequently, it is capable of preventing the initial burst of the existing injection-type drug delivery formulations and slow-release granules and providing a desired release profile, including sustained release with time.

公开(公告)号：US20120177740A1

公开(公告)日：2012-07-12

申请号：US13022734

申请日：2011-02-08

申请人： Moon Suk Kim ,  Da Yeon Kim

发明人： Moon Suk Kim ,  Da Yeon Kim

IPC分类号： A61K9/16 ,  A61K39/00 ,  A61K38/02 ,  A61P3/10 ,  A61P29/00 ,  A61P19/02 ,  A61P35/00 ,  A61P1/04 ,  A61K9/00 ,  A61P37/06

CPC分类号： A61K9/10 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/00 ,  A61K47/34

摘要： Provided is a drug delivery system for control of initial burst of a drug. More particularly, there are provided a drug delivery formulation including: a granule containing a biodegradable polymer and a drug; and a temperature-sensitive hydrogel, and a method for preparing the same. The presently disclosed drug delivery formulation can be prepared via a relatively simple process and allows a drug to be released slowly at a constant rate without initial burst and thus maintains a constant blood level of the drug for a long period of time. Consequently, it is capable of preventing the initial burst of the existing injection-type drug delivery formulations and slow-release granules and providing a desired release profile, including sustained release with time.

摘要翻译： 提供了用于控制药物的初始爆发的药物递送系统。 更具体地，提供了药物递送制剂，其包含：含有可生物降解的聚合物和药物的颗粒; 和温度敏感性水凝胶及其制备方法。 目前公开的药物递送制剂可以通过相对简单的方法制备，并且允许药物以恒定速率缓慢释放而没有初始爆发，从而长期维持药物的恒定血液水平。 因此，其能够防止现有注射型药物递送制剂和缓释颗粒的初始爆发，并提供期望的释放特征，包括随时间的持续释放。